遺伝的エナメル質形成不全症の民族間差異

Research Project

Project/Area Number	63044049
Research Category	Grant-in-Aid for international Scientific Research
Allocation Type	Single-year Grants
Section	Joint Research
Research Institution	Nippon Dental University (1990) Niigata University (1988-1989)
Principal Investigator	ISHIKI Tetsuo Nippon Dental University School of Dentistry at Niigata, 新潟歯学部, 教授 (70018406)
Co-Investigator(Kenkyū-buntansha)	COHEN M. Michael Dalhousie University School of Dentistry, 歯学部, 教授 MAIN James H. P. University of Toronto School of Dentistry, 歯学部, 教授 UENO Hiroshi Oregon Health Science University School of Dentistry, 歯学部, 教授 CERVENKA Jaroslav University of Minnesota School of Dentistry, 歯学部, 教授 WITKOP Carl J University of Minnesota School of Dentistry, 歯学部, 教授 FUKUSHIMA Masahiro Niigata University School of Dentistry, 歯学部, 助教授 (00018631)
Project Period (FY)	1988 – 1990
Project Status	Completed (Fiscal Year 1990)
Budget Amount *help	¥5,100,000 (Direct Cost: ¥5,100,000) Fiscal Year 1990: ¥1,500,000 (Direct Cost: ¥1,500,000) Fiscal Year 1989: ¥2,000,000 (Direct Cost: ¥2,000,000) Fiscal Year 1988: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords	Amelogenesis imperfecta / Racial difference / teeth anomaly
Research Abstract	At Oregon Health Science University, in 1988, the author had examined a patient who had dentinogenesis imperfecta, not amelogenesis imperfecta. We agreed to make research for this another interested inborn error. In 1989 the author received thirteen teeth from five patients. We found the other two patients, but we may receive those teeth in future after the patient having aware on this important hereditary disease. At Minnesota, the author and Professors Witkop and Cervenka discussed our contemporary classification of this anomaly in 1988, and the author received specimens of fourteen cases from them in 1989. In 1990, we discussed on two Japanese cases and reached as autosomal recessive, rough surfaced, hypoplastic and hypomaturation type. Our temporary conclusion is that there are no evident difference between the patients in United State and Japan, although the origin of these mutations in these two countrry may be different. At Toronto University we could not get satisfying cases. At Dahlhousie University, Prof. Cohen and the author discussed our epidemiological research, and finally we will revise our method. We could not find any other case in Japan now. We are now examining these materials by means of electron microprobe analysis, with cooperating with Prof. Ichijo.