The study of the origin of the polymorphism of actin filament assembly and its physiological functions

Research Project

Project/Area Number	63044066
Research Category	Grant-in-Aid for Overseas Scientific Survey.
Allocation Type	Single-year Grants
Section	Joint Research
Research Institution	Kyoto University
Principal Investigator	ITO Tadanao Associate Professor, Faculty of Science, Kyoto University, 理学部, 助教授 (90093187)
Co-Investigator(Kenkyū-buntansha)	THOMAS Stoss ハーバード医科大学, 教授 KEN Zaner ハーバード医科大学, 助教授 SATO Satoshi Associate Professor, Faculty of Science, Kyoto University, 理学部, 助手 (30183049) STOSSEL Thomas Professor, Harvard Medical School ZANER Ken Associate Professor, Harvard Medical School
Project Period (FY)	1988 – 1989
Project Status	Completed (Fiscal Year 1989)
Budget Amount *help	¥3,600,000 (Direct Cost: ¥3,600,000) Fiscal Year 1989: ¥1,800,000 (Direct Cost: ¥1,800,000) Fiscal Year 1988: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords	Actin Filament / Polymorphism of Assembly Structures / Phase Diagram / Osmoelastic Coupling / Cytoskeleton / Osmotic Pressure / Volume Regulation of Cell / Calcium
Research Abstract	The study supported by this grant is divided into four parts as follows. 1 The analysis of bundle formation of actin filaments caused by the osmoelastic coupling. 2 The analysis of liquid-crystalline phase of actin filaments. 3 Determination of phase diagram of actin filament solution. 4 Role of the cytoskeletal structure of non-muscle cell constructed by actin filaments and ABP on the response to the osmotic stress.