| Project/Area Number |
63044127
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| Research Category |
Grant-in-Aid for Overseas Scientific Survey.
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| Allocation Type | Single-year Grants |
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| Section | Joint Research |
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| Research Institution | Jichi Medical School |
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Principal Investigator |
NAKANO Masayasu Professor, Jichi Medical School, 医学部, 教授 (70048958)
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| Co-Investigator(Kenkyū-buntansha) |
SHINOMIYA Hiroto Assistant Professor, Jichi Medical School, 医学部, 講師 (80162618)
TAKI Tatsuo Assistant Professor, Jichi Medical School, 医学部, 講師 (70049097)
KLEIN Thomas Associate Professor, University of South Florida, USA., 南フロリダ大学・医学部, 准教授
SUZUKI Tsuneo Professor, University of Kansas, USA., カンザス大学・医学部, 教授
FRIEDMAN Herman Professor, University of South Florida, USA., 南フロリダ大学・医学部, 教授
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1989: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1988: ¥3,000,000 (Direct Cost: ¥3,000,000)
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| Keywords | interferon-gamma / mouse / immunecompetent cells / intracellular signal transmission / interleukin-1 / macrophages / adenylate cyclase / protein-kinase C |
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| Research Abstract |
IFN-gamma is known one of the macrophage activating factors. We examined the effect of IFN-gamma on murine peritoneal macrophages by using various parameters. The results were as follows;
1. IFN-gamma did not increase the membrane permeability, Ca^<2+> concentration, diacetylglyceride, neutral lipid and proteinkinase C activity in the cells. 2. IFN-gamma did not affect any pH and Na^+ concentration in the cells. 3. IFN-gamma suppressed the activity of adenylcyclase in the cells. 4. IFN-gamma increased the host resistance against Salmonella- and Legionella pneumophila. Simultaneous administration of IFN-gamma and TNF-alpha into mice enhanced more resistance than that of either one.
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