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Signal Transmittance on Interferon-gamma-Treated Murine Immunocompetent Cells

Research Project

Project/Area Number 63044127
Research Category

Grant-in-Aid for Overseas Scientific Survey.

Allocation TypeSingle-year Grants
SectionJoint Research
Research InstitutionJichi Medical School

Principal Investigator

NAKANO Masayasu  Professor, Jichi Medical School, 医学部, 教授 (70048958)

Co-Investigator(Kenkyū-buntansha) SHINOMIYA Hiroto  Assistant Professor, Jichi Medical School, 医学部, 講師 (80162618)
TAKI Tatsuo  Assistant Professor, Jichi Medical School, 医学部, 講師 (70049097)
KLEIN Thomas  Associate Professor, University of South Florida, USA., 南フロリダ大学・医学部, 准教授
SUZUKI Tsuneo  Professor, University of Kansas, USA., カンザス大学・医学部, 教授
FRIEDMAN Herman  Professor, University of South Florida, USA., 南フロリダ大学・医学部, 教授
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1989: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1988: ¥3,000,000 (Direct Cost: ¥3,000,000)
Keywordsinterferon-gamma / mouse / immunecompetent cells / intracellular signal transmission / interleukin-1 / macrophages / adenylate cyclase / protein-kinase C
Research Abstract

IFN-gamma is known one of the macrophage activating factors. We examined the effect of IFN-gamma on murine peritoneal macrophages by using various parameters. The results were as follows;
1. IFN-gamma did not increase the membrane permeability, Ca^<2+> concentration, diacetylglyceride, neutral lipid and proteinkinase C activity in the cells. 2. IFN-gamma did not affect any pH and Na^+ concentration in the cells. 3. IFN-gamma suppressed the activity of adenylcyclase in the cells. 4. IFN-gamma increased the host resistance against Salmonella- and Legionella pneumophila. Simultaneous administration of IFN-gamma and TNF-alpha into mice enhanced more resistance than that of either one.

Report

(1 results)
  • 1989 Final Research Report Summary
  • Research Products

    (34 results)

All Other

All Publications (34 results)

  • [Publications] Matsumura,H.: "Endotoxin-induced interferon-γ production in culture cells derived from BCG-infected C3H/HeJ mice." Journal of Immunology. 140. 494-500 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shamma,M.S.: "The mode of PGE2-induced desenstization of adenylate cyclase of a murine macrophage like cell line(P388D1)" Prostaglandins. 36. 329-341 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Blanchard,D.K.: "Role of gamma interferon in induction of natural killer cell activity by L.pneumophila in vitro and in an experimental murine injection model." Infection and Immunity. 56. 1187-1193 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamamoto,Y.: "Interferon gamma induced resistance to Legionella pneumophila by susceptible A/J mouse macrophages." Jouranal of Leukocyte Biology.(1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Terada,Y.: "Defect of calmodulin-binding protein in expression of interleukin 1 gene by LPS-nonresponder C3H/HeJ mouse macrophages." Biochemical and Biophysical Research Communication. 158. 723-729 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Nitta,T.: "Antigen-dependent and -independent proliferative T-cell populations in the peritoneal exudate cells of immunized mice." Immunology. 66. 532-541 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Onozuka,K.: "The adjuvant effect of a muramyl dipeptide(MDP)analog on temperature-sensitive Salmonella mutant vaccine." International Journal of Immunopharmacology. 11. 781-789 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Demitsu,T.: "Phagocytosis and bactericidal action of mouse peritoneal macro-phages treated with leukotrien B4." International Journal of Immunopharmacology. 11. 801-808 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamada,A.: "Fcγ2b receptor-mediated phagocytosis by a murine macrophage-like cell line(P338D1)and peritoneal resisdent macrophages:Up regulation by the inhibitors of phospholipase A2 or cyclooxygenase." Journal of Immunology. 142. 2457-2463 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamada,A.: "Regulation of Fcγ2b receptor-mediated phagocytosis by a murine macrophage cell line,P388D1:Involvement of casein kinase II activity associated with Fcγ2b receptor." Journal of Molecular and Cellular Immunology. 4. 191-201 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Adachi,I.: "Interferon-γ down regulates membrane adenylate cyclase activity of a murine macrophage-like cell line(P388D1)." Cytokine. 1. 36-44 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Matteucci,D.: "Interleukin 1 and 2 production and responsiveness in the early stages of retroviral infection." Cellular Immunology. 119. 402-411 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Blanchard,D.K.: "Induction of interferon-gamma and tumor necrosis factor by Legionella pneumophila:Augmentation of human neutrophil bactrericidal activity." Journal of Leukocyte Biology. 45. 538-549 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Wang,M-H.: "Enhancement of human monocyte factor against Candida albicans by the colony stimulating factors(CSF):Granulocyte-macrophage-CSF and macrophage-CSF." Journal of Immunology. 143. 671-680 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Matsumura,H.: "Effexct of murine recombinant interferon-γ in the protection of mice against Salmonella." Interanational Journal of Immnopharmacology. 12. 49-65 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Saito-Taki,T.: "IgG2b-dependent down regulation of the LPS-induced PFC-response and its blokade by Fcγ2bR protein." International Journal of Immunopharmacology. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Friedman,H.: "Endotoxin" Plenum Press,New York, 715 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Haruo Matsumura: "Endotoxin-induced interferon-gamma production in culture cells derived from BCG-infected C3H/HeJ mice." Journal of Immunology. 140. 494-500 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.S. Shamma: "The mode of PGE2-induced desensitization of adenylate cyclase of a murine macrophage-like cell line (P388d1)" Prostaglandins. 36. 329-341 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] D.K. Blanchard: "Role of gamma interferon in induction of natural killer cell activity by Legionella pneumophila in vitro and in an experimental murine injection model." Infection and Immunity. 56. 1187-1193 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Yamamoto: "Interferon gamma induced resistance to Legionella pneumophila by susceptible A/J mouse macrophages." Journal of Leukocyte Biology. in press. (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Terada: "Defect of calmodulin-binding protein in expression of interleukin-1 gene by LPS-nonresponder C3H/HeJ mouse macrophages." Biochemical and Biophysical Research Communications. 158. 723-729 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Nitta: "Antigen-dependent and -independent proliferative T-cell populations in the peritoneal exudate cells of immunized mice." Immunology. 66. 532-541 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Onozuka: "The adjuvant effect of a muramyl dipeptide (MDP) analog on temperature-sensitive Salmonella mutant vaccine" International Journal of Immunopharmacology. 11. 781-789 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Demitsu: "Phagocytosis and bactericidal action of mouse peritoneal macrophages treated with leukotrien B4." International Journal of Immunopharmacology. 11. 801-808 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamada, A.: "Fcgamma2b receptor-mediated phagocytosis by a murine macrophage-like cell line (P388D1) and peritoneal resident macrophages; Up regulation by the inhibitors of PLA2." Journal of Immunology. 142. 2457-2463 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamada, A.: "Regulation of Fcgamma2b receptor-mediated phagocytosis by a murine macrophage-like cell line, P388D1 : Involvement of casein kinase II activity associated with Fcgamma2b receptor." Journal of Molecular and Cellular Immunology. 4. 191-201 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Adachi, I.: "Interferon-gamma down-regulates membrane adenylate cyclase activity of a murine macrophage-like cell line (P388D1)." Cytokine. 1. 36-44 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Matteucci, D.: "Interleukin 1 and 2 production and responsiveness in the early stages of retroviral infections of mice." Cellular Immunology. 119. 402-411 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Blanchard, D.K.: "Induction of interferon-gamma and tumor necrosis factor by Legionella pneumophila: Augmentation of human neutrophil bactericidal activity." Journal of Leukocyte Biology.45. 538-549 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Wang, M-H.: "Enhancement of human monocyte factor against Candida albicans by the colony-stimulating factors (CSF): Granulocyte-macrophage-CSF and macrophage-CSF." Journal of Immunology. 143. 671-680 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Matsumura, H.: "Effect of murine recombinant interferon-gamma in the protection of mice against Salmonella." International Journal of Immunopharmacology. 12. 49-65 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Saito-Taki, T.: "IgG2b-dependent down regulation of the LPS-induced PFC-response and its blockade by Fcgamma2bR protein." International Journal of Immunopharmacology. in press. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Friedman: Endotoxin. Plenum Press, New York, 1-715 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary

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Published: 1988-04-01   Modified: 2016-04-21  

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