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Basic Study on Boron Neutron Capture Therapy of Tumors Using Research Reactors

Research Project

Project/Area Number 63045016
Research Category

Grant-in-Aid for international Scientific Research

Allocation TypeSingle-year Grants
SectionUniversity-to-University Cooperative Research
Research InstitutionKyoto University

Principal Investigator

KANDA Keiji (1990)  Research Reactor Institute, Kyoto University, 原子炉実験所, 助教授 (10027419)

石田 政弘 (1988-1989)  京都大, 原子炉実験所, 教授

Co-Investigator(Kenkyū-buntansha) ALDEMIR Tunc  Department of Nuclear Engineering, the Ohio State University, 工学部, 助教授
BARTH R.F  オハイオ州立大学, 医学部, 教授
SOLOWAY A.H  オハイオ州立大学, 薬学部, 教授
KITAOKA Yashinori  Research Reactor Institute, Kyoto University, 原子炉実験所, 助手 (00027426)
KOBAYASHI Tooru  Research Reactor Institute, Kyoto University, 原子炉実験所, 講師 (90089136)
UJENO Yowri  Research Reactor Institute, Kyoto University, 原子炉実験所, 教授 (60025541)
SOLOWAY Albert H.  College of Pharmacy, the Ohio State University
BARTH Rolf F.  Department of Pathology, the Ohio State University
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1990: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1989: ¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1988: ¥1,900,000 (Direct Cost: ¥1,900,000)
KeywordsNuclear reactor / Boron chemistry / Neutrons / Neutron Capture Therapy / Tumor / Cancer / Neutron Irradiation / Selectivity
Research Abstract

The Joint Research Reactor between the Ohio State University in U. S. A. and Kyoto University Research Reactor Institute on Boron Neutron Capture Therapy of the first stage (Fiscal 1988-1990) has been completed. Total 11 researchers, 6 Japanese and 5 Americans, were exchanged for information exchange through seminars, discussions and so on.
Boron neutron capture therapy (BNCT) is a new clinical method to treat tumors selectively by using neutrons from a nuclear research reactor. Kyoto University Research Reactor Institute (KURRI) has an advantage in developing neutron fields for biomedicine.
On the other hand the Ohio State University (OSU) has that in boron compound. Both research fields are essential for BNCT. This joint research program is based on a very typical give-and-take relation.
Through the 3 year program, both KURRI and OSU have been obtained big benefits mutually. For example, research activities of physics group in OSU and chemistry group in KURRI have stimulated very much. Many paper have been published from both sides during this program.
Both KURRI and OSU have a strong intention of the continuation of this joint research program.

Report

(1 results)
  • 1990 Final Research Report Summary
  • Research Products

    (29 results)

All Other

All Publications (29 results)

  • [Publications] K.Kanda et al: "Procedures foredical Application of Research Reactors" To be published in proceeding of 4th International Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.Kanda: "Progress of Physics Study for Boron Neutron Capture Therapy" To be published in Proceeding of 4th International Symposium on Neutron CaPture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Ujeno et al.: "clinical Experience of BNCT for Brain and Skin Tumors at kyoto Universtiy Reactor" To be Published in proceeding of 4th International Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Kobayashi et al.: "Biomedical lrradiation System Boron Neutron Capture Therapy in The kyoto University Reactor" Neutron Beam Design,Development and Performance for Neutron Capture Therapy,Plenum,NY,USA. 321-339 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.kobayashi et al.: "Relation between Tolerance Dose of Skin and Boronー10 Concentration in Neutron Capture therapy for Cutaneous Melanoma" To be published in proceeding of 4th InternationaI Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Kitaoka et al.: "A Preliminary ^1HNMR Study of Boronated Dextran for Neutron Capture Therapy" Annu.Rep.Res.Reactor Inst.kyoto Univ.22. 128-132 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M.ono et al.: "Improvement of Calculational Technique on Flux Distributions in a water Phantom Caused by Narrow Thermal Neutron Beam for Neutron Capture Therapy" Annu.Rep.Res.Reactor Inst.kyoto Univ.21. 102-108 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Kobayashi et al.: "Measurement and analysis on neutron flux distributions in a heavy water phantom using the KUR neutron guide tube for BNCT" Strahlentherapie und Onkologie. 165. 101-103 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S.Fujihara et al.: "Reevaluation of Thermal Neutron Field of the KUR Heavy water Facility for Biomedical Uses(Optimization of Bismuth Heavy Water and Graphite Layers)" Annu.Rep.Res.Reactor Inst.Kyoto Univ.23. 13-23 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Sakurai et al.: "Reevaluation of Thermal Neutron Field of KUR Heavy water Facility for Biomedical Uses(Optimization of Bismuth,Heavy water and Graphite Layers)" To be published in proceeding of 4th International Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.ujeno et al.: "The Enhancement of Thermal Neutron Induced Cell Death by Boronー10 Dextran" Strahlentherapie und Onkologie. 165. 201-202 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A.H.Soloway et al.: "Tumor Targeting Agents For Neutron Capture Therapy" Neutron Beam Design,Development and Performance for Neutron Capture Therapy,Plenum,NY,USA. 37-47 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A.H.Soloway et al.: "Boron Chemistry and Target Cell Affinity" Strahlentherapie und Onkologie. 165. 118-120 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R.F.Barth et al.: "Boron Neutron Capture Therapy of Cancer" Cancer Research. 50. 1061-1070 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R.F.Barth et al.: "Boron Neutron Capture Therapy of Cancer" Scientific American October(1990). (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Kanda et al.: "Proceedures for Medical Application of Research Reactors" To be published in Proceeding of 4th International Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Kanda: "Progress of Physics Study for Boron Neutron Capture Therapy" To be published in Proceeding of 4th International Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Ujeno et al.: "Clinical Experience of BNCT for Brain and Skin Tumors at Kyoto University Reactor" To be published in Proceeding of 4th International Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Ujeno et al.: "The Enhancement of Thermal Neutron Induced Cell Death by Boron-10 Dextran" Strahlentherapie und Onkologie. 165. 201-202 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Kobayashi et al.: "Relation between Tolerance Dose of Skin and Boron-10 Concentration in Neutron Capture therapy for Cutaneous Melanoma" To be published in Proceeding of 4th International Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Kobayashi et al.: "Biomedical Irradiation System for Boron Neutron Capture Therapy in the Kyoto University Reactor" Neutron Beam Design, Development and Performance for Neutron Capture Therapy, Plenum, NY, USA. 321-339 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Kitaoka et al.: "A Preliminary ^1H NMR Study of Boronated Dextran for Neutron Capture Therapy" Annu. Rep. Res. Reactor Inst. Kyoto Univ.22. 128-132 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. H. Soloway et al.: "Tumor Targeting Agents for Neutron Capture Therapy" Neutron Beam Design, Development and Performance for Neutron Capture Therapy, Plenum, NY, USA. 37-47 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. H. Soloway et al.: "Boron Chemistry and Target Cell Affinity" Strahlentherapie und Onkologie. 165. 118-120 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R. F. Barth et al.: "Boron Neutron Capture Therapy of Cancer" Cancer Research. 50. 1061-1070 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R. F. Barth et al.: "Boron Neutron Capture Therapy of Caner" Scientific American October (1990). (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Ono et al.: "Improvement of Calculational Technique on Flux Distributions in a Water Phantom Caused by Narrow Thermal Neutron Beam for Neutron Capture Therapy" Annu. Rep. Res. Reactor Inst. Kyoto Univ.21. 102-108 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Fujihara et al.: "Reevaluation of Thermal Neutron Field of the KUR Heavy Water Facility for Biomedical Uses (Optimization of Bismuth, Heavy Water and Graphite Layers)" Annu. Rep. Res. Reactor Inst. Kyoto Univ.23. 13-23 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Sakurai et al.: "Reevaluation of Thermal Neutron Field of the KUR Heavy Water Facility for Biomedical Uses (Optimization of Bismuth, Heavy water and Graphite Layers)" To be published in Proceeding of 4th International Symposium on Neutron Capture Therapy for Cancer. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary

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Published: 1988-04-01   Modified: 2016-04-21  

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