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Dynamics of Biomolecules in Photoreceptor Cells of Twilight and Color Vision

Research Project

Project/Area Number 63065002
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Research InstitutionKyoto University

Principal Investigator

YOSHIZAWA Toru  Kyoto Univ., Fac. of Sci., Professor, 理学部, 教授 (10028128)

Co-Investigator(Kenkyū-buntansha) FUKUDA Yoshitaka  Kyoto Univ., Fac. of Sci., Instructor, 理学部, 助手 (80165258)
SHICHIDA Yoshinori  Kyoto Univ., Fac. of Sci., Instructor, 理学部, 助手 (60127090)
MAEDA Akio  Kyoto Univ., Fac. of Sci., Associate Professor, 理学部, 助教授 (20012370)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥190,000,000 (Direct Cost: ¥190,000,000)
Fiscal Year 1990: ¥20,000,000 (Direct Cost: ¥20,000,000)
Fiscal Year 1989: ¥77,000,000 (Direct Cost: ¥77,000,000)
Fiscal Year 1988: ¥93,000,000 (Direct Cost: ¥93,000,000)
KeywordsPhotoreceptor Cells / Rhodopsin / Iodopsin / GTP-Binding Protein / Laser Flash Photolysis / Low Temperature Spectrophotometry / FTIR Spectroscopy / Amino Acid Sequence / レーザー閃光分解 / 好塩菌 / レーザー閃光分解法 / 単クローン抗体
Research Abstract

Following progresses have been made. [1] Resonance Raman spectroscopic study on 7, 9-dicis-rhodopsin demonstrated that the Schiff base linkage between its chromophore (7, 9-dicis-retinal) and bovine opsin retained anti form as in the case of rhodopsin. [2] A comparison of photoreactions between rhodopsin and 7-cis-rhodopsin revealed that an interaction between opsin and the 9-methylgroup of the chromophore changed during the lumiーmeta I transition. [3] Analysis of the photoreactions of synthetic rhodopsin analogs indicated that a conformational change around betaーionone ring of the chromophore should occur during bathoーlumi transition. [4] Laser flash photolysis of 8-memberedーrhodopsin showed that photoーbatho transition process corresponded to a relaxing pathway of highly twisted conformation of trans C_<11>-C_<12> double bond in the chromophore. [5] FTIR spectroscopy showed that the Schiff base of hypsorhodopsin was protonated. [6] In the photocycle of bacteriorhodopsin, an increase o … More f interaction between the protein moiety and the protonated Schiff base of the retinylidene chromophore was observed at the stages of both L and N intermediates by FTIR spectroscopy. [7] FTIR spectroscopy showed that Asp-96 in N intermediated of bacteriorhodopsin was deprotonated while Asp-85 was protonated. [8] Chromophore extraction experiments indicated that the photobleaching of iodopsin was initiated by the cis-trans isomerization of C_<11>-C_<12> double bond in the retinylidene chromophore. [9] It was suggested that the lifetime of metaiodopsin II would be extremely shorter than that of metarhodopsin II. [10] Analysis of epitope (s) of our monoclonal antibodies specific for iodopsin is now being investigated. The C-terminal part of iodopsin could be the antigenic ite. [11] A photobleaching intermediate of iodopsin was phosphorylated by purified bovine rhodopsin kinase. [12] A candidate protein for putative cone-specific G-protein alpha-subunit was partially purified from chicken retinas. [13] Amino acid sequence of iodopsin was deduced from its complementary DNA. Cloning of the other cone pigments in a chicken retina is now under progress. Less

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (237 results)

All Other

All Publications (237 results)

  • [Publications] Y.Shichida: "9,13ーdicisーRhodopsin and Its OneーPhotonーOneーDoubleーBond Isomerization." Biochemistry. 27. 6495-64999. (1988)

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      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Shichida: "LowーTemperature Spectrophotometry of Phoborhodopsin." FEBS Lett.236. 333-336. (1988)

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      1990 Final Research Report Summary
  • [Publications] M.Ito: "A Novel Rhodopsin Analog with Bicyclic Retinal Involving the 8ー18 Bonded Structure in the Chromophore." J. Nutr. Sci. Vitaminol.34. 641-646. (1988)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] H.Kandori: "Dependency of Apparent Relative Quantum Yield of Isorhodopsin to Rhodopsin on the Photon Density of Picosecond Laser Pulse." Photochem. Photobiol.48. 93-97. (1988)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 有木 政博: "バクテリオドプシンにおける構造と機能 ーアミノ酸残基置換の効果ー" ビタミン. 62. 301-303. (1988)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 深田 吉孝: "視物質ロドプシンやホルモン受容体とGタンパク質との相互作用部位" ビタミン. 62. 581-583. (1988)

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      1990 Final Research Report Summary
  • [Publications] 前田 章夫: "プロトンポンプとしてのバクテリオロドプシン" 生物物理. 28. 38-42 (1988)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] Y.Shichida: "Monoclonal Antibodies to Chicken Iodopsin." Exp.Eye Res.48. 281-293. (1989)

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      1990 Final Research Report Summary
  • [Publications] M.Nakagawa: "Transient Resonance Raman Spectra of Neutral and Alkaline Bacteriorhodopsin Photointermediates Observed with a DoubleーBeam Flow Apparatus:Presence of Very Fast Decaying M_<412>." Biochemistry. 28. 1347-1352. (1989)

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  • [Publications] H.Kandori: "Dependency of Photon Density on Primary Process of Cattle Rhodopsin." Photochem.Photobiol.49. 181-184. (1989)

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      1990 Final Research Report Summary
  • [Publications] Y.Fukada: "Chicken RedーSensitive Cone Visual Pigment Retains a Binding Domain for Transducin." FEBS Lett.246. 69-72. (1989)

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  • [Publications] Y.Fukada: "β γーSubunit of Bovine Transducin Composed of Two Components with Distinctive γーSubunits." J.Biol.Chem.64. 5937-5943. (1989)

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  • [Publications] M.Nakagawa: "Origin of Raman Spectral Difference between Spinning Cell and Flow Cell Measurements for Bacteriorhodopsin Photointermediates." J.Raman Spectrosc.20. 303-305. (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] H.Kandori: "Mechanism of Isomerization of Rhodopsin Studied by Use of 11ーCisーLocked Rhodopsin Analogues Excited with a Picosecond Laser Pulse." Biochemistry. 28. 6460-6467. (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] C.ーH.Kuo: "Identification of a Retinaーspecific MEKA Protein as a 33K Protein." Biochem.Biophys.Res.Commun.162. 1063-1068. (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] H.Kandori: "Absolute Absorption Spectra of Bathoー and Photorhodopsins at Room Temperature.Picosecond Laser Photolysis of Rhodopsin in Polyacrylamide." Biophys.J.56. 453-457. (1989)

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  • [Publications] Y.Imamoto: "Effect of Chloride Ion on the Thermal Decay Process of the Batho Intermediate of Iodopsin at Low Temperature." Biochemistry. 28. 9412-9416. (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] T.Okano: "Purification of Cone Visual Pigments from Chicken Retina." Biochemistry. 28. 8848-8856. (1989)

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      1990 Final Research Report Summary
  • [Publications] T.Kitagawa: "Vibrational Spectra of Rhodopsin and Bacteriorhodopsin." Photochem.Photobiol.50. 883-894. (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 神取 秀樹: "レチナ-ルタンパク質の励起状態から最初の中間体への過程の直接測定ーバクテリオロドプシンのフェムト秒レ-ザー分光ー" ビタミン. 63. 286-288. (1989)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 津田 基之: "解説:視覚の分子メカニズム." 蛋白質核酸酵素. 34. 398-404. (1989)

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  • [Publications] 吉澤 透: "ロドプシンにおける光受容機構;光励起ロドプシンに誘起される初期反応。" 蛋白質核酸酵素. 34. 405-417. (1989)

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      1990 Final Research Report Summary
  • [Publications] 前田 章夫: "レチナ-ル蛋白質におけるエネルギ-変換機構。" 蛋白質核酸酵素. 34. 428-439. (1989)

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      1990 Final Research Report Summary
  • [Publications] 深田 吉孝: "錐体における視覚初期過程の研究。" 動物生理. 6. 5-14. (1989)

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  • [Publications] 前田 章夫: "バクテリオロドプシンの光エネルギ-転換機構。" ビタミン. 63. 551-561 (1989)

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  • [Publications] 七田 芳則: "部位特異的変誘導(Siteーdirected mutagenesis)により何がわかるか。ーバクテリオロドプシンの光反応サイクルー" ビタミン. 63. 604-606. (1989)

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      1990 Final Research Report Summary
  • [Publications] Y.Fukada: "Phosphorylation of Iodopsin,Chicken RedーSensitive Cone Visual Pigment." Biochemistry. 29. 10102-10106 (1990)

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  • [Publications] T.Nishiya: "The Use of Circular Dichroism Active Phospholipid to Study BeacteriorhodopsinーLipid Interaction.Effects of Lipid to Protein Ratio and Crosslinkings of Lysine Residues." Chem.Phys.Lipid. 55. 115-122. (1990)

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  • [Publications] A.Trehan: "On Retention of Chromophore Configuration of Rhodopsin Isomers Derived from Three dicis Retinal Isomers." Bioorg.Chem.18. 30-40. (1990)

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  • [Publications] Y.Fukada: "Comparative Study on the Chromophore Binding Sites of Rod and RedーSensitive Cone Visual Pigments by Use of Sybthetic Retinal Isomers and Analogues." Biochemistry. 29. 3133-3140. (1990)

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  • [Publications] Y.Shichida: "Effects of Chloride on Chicken Iodopsin and the Chromophore Transfer Reactions from Iodopsin to Scotopsin and BーPhotopsin." Biochemistry. 29. 5843-5848. (1990)

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  • [Publications] M.Araki: "Localization of Iodopsin in the Chick Retina during in Vivo and in Vitro Cone Differentiation." Invest.Ophthalmol.Vis.Sci.31. 1466-1473. (1990)

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  • [Publications] T.Oishi: "Immunohistochemical Localization of Iodopsin in the Retina of the Chicken and Japanese Quail." Cell.Tissue Res.261. 397-401. (1990)

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  • [Publications] G.R.Loppnow: "Structure of the Retinal Chromophore in 7,9ーdicisーRhodopsin." Biochemistry. 29. 8985-8991. (1990)

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  • [Publications] H.Kandori: "Bathoiodopsin,a Primary Intermediate of Iodopsin at Physiological Temperature." Proc.Natl.Acad.Sci.USA. 87. 8908-8912. (1990)

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  • [Publications] O.Kuwata: "The Primary Structure of Iodopsin,a Chicken RedーSensitive Cone Pigment." FEBS Lett.272. 128-132. (1990)

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  • [Publications] Y.Fukada: "Binding of GTP to Transducin is not Inhibited by Arrestin and Phosphorylated Rhodopsin." FEBS Lett.261. 419-422. (1990)

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  • [Publications] H.Ohguro: "A Specific β γーSubunit of Transducin Stimulates ADPーRibosylation of the αーSubunit by Pertussis Toxin." Biochem.Biophys.Res.Commun.167. 1235-1241. (1990)

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  • [Publications] H.Ohguro: "Functional Heterogeneity of β γーSubunit of Frog Transducin." Comp.Biochem.Physiol.95B. 763-765. (1990)

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  • [Publications] Y.Fukada: "Farnesylated γーSubunit of Photoreceptor G Protein Indispensable for GTPーBinding." Nature. 346. 658-660. (1990)

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  • [Publications] Y.Shichida: "UltraーFast Laser Spectroscopy of Visual Pigments." Photochem.Photobiol.52. 1179-1185. (1990)

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  • [Publications] 七田 芳則: "光受容物質の分子構造と動態" 細胞. 22. 128-132. (1990)

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  • [Publications] 吉澤 透: "感覚受容の分子メカニズム。" 日本の科学と技術. 31. 50-56. (1990)

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  • [Publications] 深田 吉孝: "色受容に関与する機能蛋白質。" 実験医学. 8. 76-79. (1990)

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  • [Publications] 吉澤 透: "視物質とビタミンA。" ビタミン. 64. 95-98. (1990)

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  • [Publications] 吉澤 透: "レチナ-ルタンパク質レベルからの色覚研究 ー錐体視物質アイオドプシンとクロライドー。" ビタミン. 64. 412-414. (1990)

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  • [Publications] 吉澤 透: "ロドプシンと光から電気への信号変換。" BRAIN MEDICAL. 2. 53-61. (1990)

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  • [Publications] 吉澤 透: "視覚受容の分子機構。" 蛋白質核酸酵素. 35. 588-598 (1990)

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  • [Publications] 吉澤 透: "錐体の光感受性レチナ-ルタンパク質アイオドプシンの精製とその局在。" ビタミン. 64. 614-615. (1990)

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  • [Publications] 深田 吉孝: "光受容とG蛋白質。" 実験医学増刊. 8. 48-53. (1990)

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  • [Publications] M.Nakagawa: "Idebtification of the LongーLived L'Species of Bacteriodopsin as the N Intermediate by Raman/Absorption QuasiーSimultaneous Measurements." J.Mol.Struct.242. 221-234. (1991)

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  • [Publications] T.Yoshizawa: "Biochemical and Photochemical Analyses of Retinal Proteins in Chicken Cone Cells." Pure & Appl.Chem.63. 171-176. (1991)

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  • [Publications] T.Okada: "A Spectroscopic Study of the Batho to Lumi Tansition during the Photobleaching of Rhodopsin Using Ring Modified Rhodopsin Analogs." Biochemistry. (1991)

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  • [Publications] T.Takao: "Determination of Posttranslationally Modified Structures in Proteins by Accurate Mass Measurement in FAB Mass Spectrometry." Peptide Chem.(1991)

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  • [Publications] A.Maeda: "Fourier Transform Infrared Spectral Studies on the Schiff Base Mode of Allーtrans Bacteriorhodopsin and Its Photointermediates,K and L." Photochem.Photobiol.(1991)

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  • [Publications] Y.Shichida: "Differences in the Photobleaching Process between 7ーCisー and 11ーCisーRhodopsins:A Unique Interaction Change between the Chromophore and the Protein During the LumiーMeta I Transition." Biochemistry. (1991)

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  • [Publications] T.Yoshizawa: "Iodopsin,a Red Sensitive Cone Visual Pigment in Chicken Retina." Photochem.Photobiol.(1991)

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  • [Publications] J. ーM. Pfefferle^^′: "Fourier Transform nfrared Study on Structural Changes Induced in the N Intermediate of Bacteriorhodopsin."

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  • [Publications] Y.Imamoto: "The Photoreaction Cycle of Phoborhodopsin Studied by Low Temperature Spectuophotometry."

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      1990 Final Research Report Summary
  • [Publications] 深田 吉孝: "ファルネシル化タンパク質。" 生化学. 63. 52. (1991)

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  • [Publications] 吉澤 透: "高度好塩菌の色弁別に関与するレチナ-ルタンパク質 ーフォボロドプシンー。" ビタミン. (1991)

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      「研究成果報告書概要(和文)」より
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      1990 Final Research Report Summary
  • [Publications] 深田 吉孝: "色応答の分子基盤 〜錐体視物質アイオドプシンの構造と機能〜" 生物物理. (1991)

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      1990 Final Research Report Summary
  • [Publications] 深田 吉孝: "光情報の生化学。" 代謝臨時増刊. (1991)

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      1990 Final Research Report Summary
  • [Publications] 深田 吉孝: "視細胞G蛋白質のγサブユニットの構造と機能" 医学のあゆみ. (1991)

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      1990 Final Research Report Summary
  • [Publications] 吉澤 透: "医学書院" 視物質。新生理学大系9感覚の生理学 (田崎京二、小川哲朗編). 14 (1989)

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      1990 Final Research Report Summary
  • [Publications] 深田 吉孝: "広川書店" ニワトリ錐体および桿体視物質の抽出と精製 生物薬科科学実験講座 VI巻 『ホルモンと生理活性物質』.

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  • [Publications] T.Yoshizawa: "The Rockfeller University Press"

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      1990 Final Research Report Summary
  • [Publications] 前田 章夫: "バクテリオロドプシン 情報生物学シリ-ズ2、 「神経情報伝達分子」。" 培風館, 7 (1988)

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    • Related Report
      1990 Final Research Report Summary
  • [Publications] 吉澤 透: "生物物理学。 学問の現在諸学問の鳥瞰図" 駸々堂, 11 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 深田 吉孝: "視細胞における情報変換。シリ-ズ「分子生物学の進歩」 第11巻「分子神経生物学」 (御子柴克彦、野田昌晴 編集)" 丸善, 17 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T.Yoshizawa: "Visual Transduction Process in Vertebrate Photoreceptor Cell.in Physiology and Pharmacology of Transmembrane Signalling" Elsevier Science Publishers BV, 9 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R.S.H.Liu: "Organzation in Biological Systems I Photochemistry in Organized and Constrained Media." VCH Publishers,New York.,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R.S.H.Liu: "Organzation in Biological Systems I Photochemistry in Organized and Constrained Media." VCH Publishers,New York., "Primary Photochemical Events in the Rhodopsin Molecule.Progress in Retinal Research(Osborne and Chader eds.)"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Shichida, K. Nakamura, T. Yoshizawa, A. Trehan, M. Denny & R. S. H. Liu: "9, 13-dicisーRhodopsin and Its One-Photon-One-DoubleーBond Isomerization." Biochemistry. 27. 6495-6499 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Shichida, Y. Imamoto, T. Yoshizawa, T. Takahashi, H. Tomioka, N. Kamo & Y. Kobatake: "Low-Temperature Spectrophotometry of Photorhodopsin." FEBS Lett. 236. 333-336 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Ito, Y. Mantani, K. Tsukida, Y. Shichida, S. Ioshida, Y. Fukada, & T. Yoshizawa: "A Novel Rhodopsin Analog with Bicyclic Retinal Involving the 8-18 Bonded Structure in the Chromophore." J. Nutr. Sci. Vitaminol. 34. 641-646 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Kandori, S. Matuoka, H. Nagai, Y. Shichida & T. Yoshizawa: "Dependency of Apparent Relative Quantum Yiels of Isorhodopsin to Rhodopsin on the Photon Density of Picosecond Laser Pulse." Photochem. Photobiol.,. 48. 93-97 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Shichida, Y. Taniguchi, O. Kuwata, Y. Fukada, T. Yoshizawa, S. Horiuchi & M. Takeichi: "Monoclonal Antibodies to Chicken Lodopsin." Exp. Eye Res.48. 281-293 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Nakagawa, T. Ogura, A. Maeda & T. Kitagawa,: "Transient Resonance Raman Spectra of Neutral and Alkaline Bacteriorhodopsin Photointermediates Observed with a Double-Beam Flow Apparatus : Presence of very fast decaying M_<412>^・" Biochemistry. 28. 1347-1352 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Kandori, S. Matuoka, Y. Shichida & T. Yoshizawa: "Dependency of Photon Density on Primary Process of Cattle Rhodopsin." Photochem. Photobiol.49. 181-184 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Fukada, T. Okano, I. D. Artamonov & T. Yoshizawa,: "Chicken Red-Sensitive Cone Visual Pigment Retains a Binding Domain for Transducin." FEBS Lett.246. 69-72 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Fukada, H. Ohguro, T. Saito, T. Yoshizawa & T. Akino: "Beta Gamma- Subunit of Bovine Transducin Composed of Two Components with Distinctive gammaーSubunits." J. Biol. Chem.264. 5937-5943 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Nakagawa, A. Maeda, T. Ogura & T. Kitagawa: "Origin of Raman Spectral Difference between Spinning Cell and Flow Cell Measurements for Bacteriorhodopsin Photointermediates." J. Raman Spectrosc. 20. 303-305 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Kandori, S. Matuoka, Y. Shichida, T. Yoshizawa, M. Ito, K. Tsukida, V. Balogh-Nair & K. Nakanishi: "Mechanism of Isomerization of Rhodopsin Studied by Use of 11-CisーLocked Rhodopsin Analogs Excited with a Picosecond Laser Pulse." Biochemistry. 28. 6460-6467 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] C. -H. Kuo, H. Taniura, Y. Watanabe, Y. Fukada, T. Yoshizawa & N. Miki: "Identification of a Retina-specific MEKA Protein as a 33K Protein." Biochem. Biophys. Res. Commun.162. 1063-1068 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Kandori, Y. Shichida & T. Yoshizawa: "Absolute Absorption Spectra of Batho- and Photorhodopsins at Room Temperature. Picosecond Laser Photolysis of Rhodopsin in Polyacrylamide." Biophys. J.56. 453-457 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Imamoto, H. Kandori, T. Okano, Y. Fukada, Y. Shichida & T. Yoshizawa: "Effect of Chloride Ion on the Thermal Decay Process of the Batho Intermediate of Iodopsin at Low Temperature." Biochemistry. 28. 9412-9416 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Okano, Y. Fukada, I. D. Artamonov & T. Yoshizawa: "Purification of Cone Visual Pigments from Chicken Retina." Biochemistry. 28. 8848-8856 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Kitagawa & A. Maeda,: "Vibrational Spectra of Rhodopsin and Bacteriorhodopsin." Photochem. Photobiol.50. 883-894 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Yoshizawa & Y. Fukada: "Visual Transduction Process in Vertebrate Photoreceptor Cell." Physiology and Pharmacology of Transmembrane Signalling (T. Segawa, M. Endo, M. Ul & K. Kurihara eds.) Elsevier Science Publishers BV. 307-315 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Nishiya & A. Maeda: "The use of Circular Dichroism Active Phospholipid to study Bacteriorhodopsin-Lipid Interation. Effects of lipid to Protein Ratio and Crosslinkings of Lysine Residues." Chem. Phys. Lipid. 5. 115-122 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. Trehan, R. S. H. Liu, Y. Shichida, Y. Imamoto, K. Nakamura & T. Yoshizawa: "On Retention of Chromophore Configuration of Rhodopsin Isomers Derived from three Dicis Retinal Isomers." Bioorg. Chem.18. 30-40 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Fukada, T. Okano, Y. Shichida, T. Yoshizawa, A. Trehan, D. Mead, M. Denny, A. E. Asato & R. S. H. Liu: "Comparative Study on the Chromophore Binding Sites of Rod and RedーSensitive Cone Visual Pigments by Use of Synthetic Retinal Isomers and Analogs." Biochemistry. 29. 3133-3140 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Shichida, T. Kato, S. Sasayama, Y. Fukada & T. Yoshizawa,: "Effects of Chloride on Chicken Iodopsin and the Chromophore Transfer Reactions from Lodopsin to Scotopsin and B-Photopsin." Biochemistry. 29. 5843-5848 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Araki, Y. Fukada, Y. Shichida & T. Yoshizawa: "Localization of Lodopsin in the Chick Retina during in Vivo and in Vitro Cone Differentiation." Invest. Ophthalmol. Vis. Sci.31. 1466-1473 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Oishi, A. Kawata, T. Hayashi, Y. Fukuda, Y. Shichida & T. Yoshizawa: "Immunohistochemical Localization of Lodopsin in the Retina of the Chicken and Japanese Quail." Cell. Tissue Res.261. 397-401 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] G. R. Loppnow, M. E. Miley, R. A. Mathies, R. S. H. Liu, H. Kandori, Y. Shichida, Y. Fukada & T. Yoshizawa: "Structure of the Retinal Chromophore in 7, 9-Dicis-Rhodopsin." Biochemistry. 29. 8985-8991 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Kandori, T. Mizukami, T. Okada, Y. Imamoto, Y. Fukada, Y. Shichida & T. Yoshizawa: "Bathoiodopsin, a Primary Intermediate of Lodopsin at Physiological Temperature." Proc. Natl. Acad. Sci. USA. 87. 8908-8912 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Fukada, K. Kokame, T. Okano, Y. Shichida, T. Yoshizawa, J. H. McDowell, P. A. Hargrave & K. Palczewski: "Phosphorylation of Lodopsin, Chicken Red-Sensitive Cone Visual Pigment." Biochemistry. 29. 10102-10106 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Fukada, T. Yoshizawa, T. Saito, H. Ohguro & T. Akino: "Binding of GTP to Transducin is not inhibited by Arrestin and Phosphorylated Rhodopsin." FEBS Lett.261. 419-422 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] O. Kuwata, Y. Imamoto, T. Okano, K. Kokame, D. Kojima, H. Matsumoto, A. Morodome, Y. Fukada Y. Shichida, K. Yasuda, Y. Shimura & T. Yoshizawa: "The Primary Structure of Lodopsin, a Chicken RedーSensitive Cone Pigment." FEBS Lett.272. 128-132 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Ohguro, Y. Fukada, T. Yoshizawa, T. Saito & T. Akino: "A specific Beta GammaーSubunit of Transducin Stimulates ADP-Ribosylation of the Alpha-Subunit by Pertussis Toxin." Biochem. Biophys. Res. Commun.167. 1235-1241 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] H. Ohguro, Y. Fukada, T. Saito & T. Akino: "Functional Heterogeneity of beta gamma-Subunit of Frog Transducin." Comp Biochem Physiol. 95B. 763-765 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Fukada, T. Takao, H. Ohguro, T. Yoshizawa, T. Akino, & Y. Shimonishi,: "Farnesylated Gamma-Subunit of Photoreceptor G Protein Indispensable for GTP-Binding." Nature. 346. 658-660 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Shichida: "Ultra-Fast Laser Spectroscopy of Visual Pigments." Photochem. Photobiol.52. 1179-1185 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Yoshizawa, Y. Shichida & Y. Fukada: "Biochemical and Photochemical Analyses of Retinal Proteins in Chicken Cone Cells." Pure Appl. Chem.63. 171-176 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] M. Nakagawa, A. Maeda, T. Ogura & T. Kitagawa: "Identification of the Long-Lived L'Species of Bacteriorhodopsin as the N Intermediate by Raman/Absorption Quasi-Simultaneous Measurements." J. Mol. Struct.242. 221-234 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] R. S. H. Liu & Y. Shichida: "Organization in Biological Systems I. Protein Directed Regioselective Photoisomerization of the Retinyl Chromophore in Visual Pigment Analogs." Photochemistry in Organized and Constrained Media. (M. Grayson ed.) VCH Publishers, New York.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Shichida, H. Kandori, T. Okada, T. Yoshizawa, N. Nakashima & K. Yoshihara: "Differences in the Photobleaching Process between 7-Cis-and 11-Cis-Rhodopsins : A unique interaction change between the Chromophore and the Protein During the Lumi-Meta I Transition." Biochemistry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Okada, H. Kandori, Y. Shichida, T. Yoshizawa, M. Denny, B. ーW. Zhang, A. E. Asoto & R. S. H. Liu: "A Spectroscopic Study of the Batho to Lumi Tansition during the Photobleaching of Rhodopsin using Ring Modified Rhodopsin Analogs." Biochemistry.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Takao, Y. Fukada, H. Ohguro, T. Yoshizawa, T. Akino & Y. Shimonishi: "Determination of Posttranslationally Modified Structures in Proteins by Accurate Mass Measurement in FAB Mass Spectrometry." Peptide Chem.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] A. Maeda, J. Sasaki, J. -M. Pfefferle, Y. Shichida & T. Yoshizawa: "Fourier Transform Infrared Spectral Studies on the Schiff Base Mode of All-trans Bacteriorhodopsin and Its Photointermediates, K and L." Photochem. Photobiol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Yoshizawa & O. Kuwata: "Lodopsin, a Red Sensitive Cone Visual Pigment in Chicken Retina." Photochem. Photobiol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] T. Yoshizawa & H. Kandori: "Primary Photochemical Events in the Rhodopsin Molecule." Progress in Retinal Research (Osborne and chader eds.) The Rockfeller University Press.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Imamoto, Y. Shichida, T. Yoshizawa, H. Tomioka, T. Takahashi, K. Fujikawa, N. Kamo & Y. Kobatake: "The Photoreaction Cycle of Phoborhodopsin Studied by Low Temperature Spectrophotometry."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] J. -M. Pfefferle, A. Maeda, J. Sasaki & T. Yoshizawa: "Fourier Transform Infrared Study on Structural Changes Induced in the N Intermediate of Bacteriorhodopsin."

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Shichida: "9,13ーdicisーRhodopsin and Its OneーPhotonーOneーDoubleーBond Isomerization." Biochemistry. 27. 6495-6499 (1988)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Shichida: "LowーTemperature Spectrophotometry of Phoborhodopsin." FEBS Lett.236. 333-336 (1988)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Ito: "A Novel Rhodopsin Analog with Bicyclic Retinal Involving the 8ー18 Bonded Structure in the Chromophore." J.Nutr.Sci.Vitaminol.34. 641-646 (1988)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Kandori: "Dependency of Apparent Relative Quantum Yield of Isorhodopsin to Rhodopsin on the Photon Density of Picosecond Laser Pulse." Photochem.Photobiol.48. 93-97 (1988)

    • Related Report
      1990 Annual Research Report
  • [Publications] 有木 政博: "バクテリオロドプシンにおける構造と機能ーアミノ酸残基置換の効果ー" ビタミン. 62. 301-303 (1988)

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      1990 Annual Research Report
  • [Publications] 深田 吉孝: "視物質ロドプシンやホルモン受容体とGタンパク質との相互作用部位" ビタミン. 62. 581-583 (1988)

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      1990 Annual Research Report
  • [Publications] 前田 章夫: "プロトンポンプとしてのバクテリオロドプシン" 生物物理. 28. 38-42 (1988)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Shichida: "Monoclonal Antibodies to Chicken Iodopsin." Exp.Eye Res.48. 281-293 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Nakagawa: "Transient Resonance Raman Spectra of Neutral and Alkaline Bacteriorhodopsin Photointermediates Observed with a DoubleーBeam Flow Apparatus: Presence of Very Fast Decaying M_<412>." Biochemistry. 28. 1347-1352 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Kandori: "Dependency of Photon Density on Primary Process of Cattle Rhodopsin." Photochem.Photobiol.49. 181-184 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Fukada: "Chicken RedーSensitive Cone Visual Pigment Retains a Binding Domain for Transducin." FEBS Lett.246. 69-72 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Fukada: "β γーSubunit of Bovine Transducin Composed of Two Components with Distinctive γーSubunits." J.Biol.Chem.64. 5937-5943 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] M.Nakagawa: "Origin of Raman Spectral Difference between Spinning Cell and Flow Cell Measurements for Bacteriorhodopsin Photointermediates." J.Raman Spectrosc.20. 303-305 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Kandori: "Mechanism of Isomerization of Rhodopsin Studied by Use of 11ーCisーLocked Rhodopsin Analogues Excited with a Picosecond Laser Pulse." Biochemistry. 28. 6460-6467 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] C.ーH.Kuo: "Identification of a Retinaーspecific MEKA Protein as a 33K Protein." Biochem.Biophys.Res.Commun.162. 1063-1068 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] H.Kandori: "Absolute Absorption Spectra of Bathoー and Photorhodopsins at Room Temperature.Picosecond Laser Photolysis of Rhodopsin in Polyacrylamide." Biophys.J.56. 453-457 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Imamoto: "Effect of Chloride Ion on the Thermal Decay Process of the Batho Intermediate of Iodopsin at Low Temperature." Biochemistry. 28. 9412-9416 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Okano: "Purification of Cone Visual Pigments from Chicken Retina." Biochemistry. 28. 8848-8856 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Kitagawa: "Vibrational Spectra of Rhodopsin and Bacteriorhodopsin." Photochem.Photobiol.50. 883-894 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 神取 秀樹: "レチナ-ルタンパク質の励起状態から最初の中間体への過程の直接測定ーバクテリオロドプシンのフェムト秒レ-ザ-分光ー" ビタミン. 63. 286-288 (1989)

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      1990 Annual Research Report
  • [Publications] 津田 基之: "解説:視覚の分子メカニズム。" 蛋白質核酸酵素. 34. 398-404 (1989)

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      1990 Annual Research Report
  • [Publications] 吉澤 透: "ロドプシンにおける光受容機構;光励起ロドプシンに誘起される初期反応。" 蛋白質核酸酵素. 34. 405-417 (1989)

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      1990 Annual Research Report
  • [Publications] 前田 章夫: "レチナ-ル蛋白質におけるエネルギ-変換機構。" 蛋白質核酸酵素. 34. 428-439 (1989)

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      1990 Annual Research Report
  • [Publications] 深田 吉孝: "錐体における視覚初期過程の研究。" 動物生理. 6. 5-14 (1989)

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      1990 Annual Research Report
  • [Publications] 前田 章夫: "バクテリオロドプシンの光エネルギ-転換機構。" ビタミン. 63. 551-561 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 七田 芳則: "部位特異的変異誘導(Siteーdirected mutagenesis)により何がわかるか。ーバクテリオロドプシンの光反応サイクルー" ビタミン. 63. 604-606 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Fukada: "Phosphorylation of Iodopsin,Chicken RedーSensitive Cone Visual Pigment." Biochemistry. 29. 10102-10106 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] T.Nishiya: "The Use of Circular Dichroism Active Phospholipid to Study BacteriorhodopsinーLipid Interaction.Effects of Lipid to Protein Ratio and Crosslinkings of Lysine Residues." Chem.Phys.Lipid. 55. 115-122 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] A.Trehan: "On Retention of Chromophore Configuration of Rhodopsin Isomers Derived from Three dicis Retinal Isomers." Bioorg.Chem.18. 30-40 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Fukada: "Comparative Study on the Chromophore Binding Sites of Rod and RedーSensitive Cone Visual Pigments by Use of Synthetic Retinal Isomers and Analogues." Biochemistry. 29. 3133-3140 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Y.Shichida: "Effects of Chloride on Chicken Iodopsin and the Chromophore Transfer Reactions from Iodopsin to Scotopsin and BーPhotopsin." Biochemistry. 29. 5843-5848 (1990)

    • Related Report
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  • [Publications] M.Araki: "Localization of Iodopsin in the Chick Retina during in Vivo and in Vitro Cone Differentiation." Invest.Ophthalmol.Vis.Sci.31. 1466-1473 (1990)

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  • [Publications] T.Oishi: "Immunohistochemical Localization of Iodopsin in the Retina of the Chicken and Japanese Quail." Cell.Tissue Res.261. 397-401 (1990)

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  • [Publications] G.R.Loppnow: "Structure of the Retinal Chromophore in 7,9ーdicisーRhodopsin." Biochemistry. 29. 8985-8991 (1990)

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  • [Publications] H.Kandori: "Bathoiodopsin,a Primary Intermediate of Iodopsin at Physiological Temperature." Proc.Natl.Acad.Sci.USA. 87. 8908-8912 (1990)

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  • [Publications] O.Kuwata: "The Primary Structure of Iodopsin,a Chicken RedーSensitive Cone Pigment." FEBS Lett.272. 128-132 (1990)

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  • [Publications] Y.Fukada: "Binding of GTP to Transducin is not Inhibited by Arrestin and Phosphorylated Rhodopsin." FEBS Lett.261. 419-422 (1990)

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  • [Publications] H.Ohguro: "A Specific β γーSubunit of Transducin Stimulates ADPーRibosylation of the αーSubunit by Pertussis Toxin." Biochem.Biophys.Res.Commun.167. 1235-1241 (1990)

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  • [Publications] H.Ohguro: "Functional Heterogeneity of β γーSubunit of Frog Transducin." Comp.Biochem.Physiol.95B. 763-765 (1990)

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  • [Publications] Y.Fukada: "Farnesylated γーSubunit of Photoreceptor G Protein Indispensable for GTPーBinding." Nature. 346. 658-660 (1990)

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  • [Publications] Y.Shichida: "UltraーFast Laser Spectroscopy of Visual Pigments." Photochem.Photobiol.52. 1179-1185 (1990)

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  • [Publications] 七田 芳則: "光受容物質の分子構造と動態" 細胞. 22. 128-132 (1990)

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  • [Publications] 吉澤 透: "感覚受容の分子メカニズム。" 日本の科学と技術. 31. 50-56 (1990)

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  • [Publications] 深田 吉孝: "色受容に関与する機能蛋白質。" 実験医学. 8. 76-79 (1990)

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  • [Publications] 吉澤 透: "視物質とビタミンA。" ビタミン. 64. 95-98 (1990)

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  • [Publications] 吉澤 透: "レチナ-ルタンパク質レベルからの色覚研究ー錐体視物質アイオドプシンとクロライドー。" ビタミン. 64. 412-414 (1990)

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  • [Publications] 吉澤 透: "ロドプシンと光から電気への信号変換。" BRAIN MEDICAL. 2. 53-61 (1990)

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  • [Publications] 吉澤 透: "視覚受容の分子機構。" 蛋白質核酸酵素. 35. 588-598 (1990)

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  • [Publications] 吉澤 透: "錐体の光感受性レチナ-ルタンパク質アイオドプシンの精製とその局在。" ビタミン. 64. 614-615 (1990)

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  • [Publications] 深田 吉孝: "光受容とG蛋白質。" 実験医学増刊. 8. 48-53 (1990)

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  • [Publications] M.Nakagawa: "Identification of the LongーLived L' Species of Bacteriorhodopsin as the N Intermediate by Raman/Absorption QuasiーSimultaneous Measurements." J.Mol.Struct.242. 221-234 (1991)

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  • [Publications] T.Yoshizawa: "Biochemical and Photochemical Analyses of Retinal Proteins in Chicken Cone Cells." Pure & Appl.Chem.63. 171-176 (1991)

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  • [Publications] T.Okada: "A Spectroscopic Study of the Batho to Lumi Tansition during the Photobleaching of Rhodopsin Using Ring Modified Rhodopsin Analogs." Biochemistry. (1991)

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  • [Publications] T.Takao: "Determination of Posttranslationally Modified Structures in Proteins by Accurate Mass Measurement in FAB Mass Spectrometry." Peptide Chem.(1991)

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  • [Publications] A.Maeda: "Fourier Transform Infrared Spectral Studies on the Schiff Base Mode of Allーtrans Bacteriorhodopsin and Its Photointermediates,K and L." Photochem.Photobiol.(1991)

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  • [Publications] Y.Shichida: "Differences in the Photobleaching Process between 7ーCisー and 11ーCisーRhodopsins: A Unique Interaction Change between the Chromophore and the Protein During the LumiーMeta I Transition." Biochemistry. (1991)

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      1990 Annual Research Report
  • [Publications] T.Yoshizawa: "Iodopsin,a Red Sensitive Cone Visual Pigment in Chicken Retina." Photochem.Photobiol.(1991)

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      1990 Annual Research Report
  • [Publications] J.ーM.Pfefferle^^´: "Fourier Transform Infrared Study on Structural Changes Induced in the N Intermediate of Bacteriorhodopsin."

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      1990 Annual Research Report
  • [Publications] Y.Imamoto: "The Photoreaction Cycle of Phoborhodopsin Studied by Low Temperature Spectrophotometry."

    • Related Report
      1990 Annual Research Report
  • [Publications] 深田 吉孝: "ファルネシル化タンパク質。" 生化学. 63. 52 (1991)

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  • [Publications] 吉澤 透: "高度好塩菌の色弁別に関与するレチナ-ルタンパク質ーフォボロドプシンー。" ビタミン. (1991)

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  • [Publications] 深田 吉孝: "色応答の分子基盤〜錐体視物質アイオドプシンの構造と機能〜" 生物物理. (1991)

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  • [Publications] 深田 吉孝: "光情報の生化学。" 代謝臨時増刊. (1991)

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      1990 Annual Research Report
  • [Publications] 深田 吉孝: "視細胞G蛋白質のγサブユニットの構造と機能" 医学のあゆみ. (1991)

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  • [Publications] 前田 章夫: "バクテリオロドプシン情報生物学シリ-ズ2、「神経情報伝達分子」。" 培風館, 7 (1988)

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  • [Publications] 吉澤 透: "生物物理学。学問の現在諸学問の鳥瞰図" 駸々堂, 11 (1989)

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  • [Publications] 深田 吉孝 (御子柴 克彦、野田 昌晴 編集): "視細胞における情報変換。シリ-ズ「分子生物学の進歩」第11巻「分子神経生物学」" 丸善, 17 (1989)

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  • [Publications] T.Yoshizawa: "Visual Transduction Process in Vertebrate Photoreceptor Cell.in Physiology and Pharmacology of Transmembrane Signalling" Elsevier Science Publishers BV, 9 (1989)

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      1990 Annual Research Report
  • [Publications] 吉澤 透 (田崎 京二、小川 哲朗編): "視物質。新生理学大系9感覚の生理学" 医学書院, 14 (1989)

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  • [Publications] 深田 吉孝: "ニワトリ錐体および桿体視物質の抽出と精製 生物薬科科学実験講座VI巻『ホルモンと生理活性物質』" 広川書店,

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  • [Publications] T.Yoshizawa (Osborne and Chader eds.): "Primary Photochemical Events in the Rhodopsin Molecule.Progress in Retinal Research" The Rockfeller University Press,

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  • [Publications] R.S.H.Liu: "Organization in Biological Systems I Photochemistry in Organized and Constrained Media." VCH Publishers,New York.,

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  • [Publications] Masasuke Araki: "Localization of iodopsin in the chick retina during in vivo and in vitro cone differentiation." Invest.Ophthalmol.

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  • [Publications] Yoshitaka Fukada: "Chicken red-sensitive cone visual pigment retains a binding domain for transducin." FEBS Lett.246. 69-72 (1989)

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  • [Publications] Yoshitaka Fukada: "βγ-subunit of bovine transducin composed of two components with distinctive γ-subunits." J.Biol.Chem.264. 5937-5943 (1989)

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  • [Publications] 深田吉孝: "錐体における視覚初期過程の研究" 動物生理(10周年記念号). 6. 5-14 (1989)

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  • [Publications] Yoshitaka Fukada: "Comparative study on the chromophore binding sites of rod and red-sensitive cone visual pigments by use of synthetic retinal isomers and analogues." Biochemistry.

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  • [Publications] Yoshitaka Fukada: "Binding of GTP to transducin is not inhibited by arrestin and phosphorylated rhodopsin." FEBS Lett.

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  • [Publications] Yasushi Imamoto: "Effect of chloride ion on the thermal decay process of the batho intermediate of iodopsin at low temperature." Biochemistry. 28. 9412-9416 (1989)

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  • [Publications] Hideki Kandori: "Mechanism of isomerization of rhodopsin studied by use of 11-cis-locked rhodopsin analogues excited with a picosecond laser pulse." Biochemistry. 28. 6460-6467 (1989)

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  • [Publications] Hideki Kandori: "Absolute absorption spectra of batho-and photo-rhodopsin at room temperature.Picosecond laser photolysis of rhodopsin in polyacrylamide gel." Biophys.J.56. 453-457 (1989)

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  • [Publications] 神取秀樹: "レチナールタンパク質の励起状態から最初の中間体への過程の直接測定" ビタミン. 63. 286-288 (1989)

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  • [Publications] Teizo Kitagawa: "Vibrational spectra of rhodopsin and bacteriorhodopsin." Photochem.Photobiol.50. 883-894 (1990)

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  • [Publications] Che-Hui Kuo: "Identification of a retina-specific MEKA protein as a 33K Protein." Biochem.Biophys.Res.Commun.162. 1063-1089 (1989)

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  • [Publications] 前田章夫: "バクテリオロドプシンの光エネルギー転換機構" ビタミン. 63. 551-561 (1989)

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  • [Publications] Masashi Nakagawa: "Transient resonance raman spectra of neutral and alkaline bacteriorhodopsin photointermediates observed with a double-beam flow apparatus:Presence of very fast decaying M412." Biochemistry. 28. 1347-1352 (1989)

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      1989 Annual Research Report
  • [Publications] Masashi Nakagawa: "Origin of Raman spectral difference between spinning cell and flow cell measurements for bacteriorhodopsin photointermediates." J.Raman Spectroscopy. 20. 303-305 (1989)

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  • [Publications] Masashi Nakagawa: "Identification of the long-lived L'species of bacteriorhodopsin to be the N intermediate by Raman/absorption quasi-simultaneous measurement." J.Mol.Spectroscopy.

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  • [Publications] Takako Nishiya: "The use of circular dichroism active phospholipid to study bacteriorhodopsin-lipid interaction.Effects of lipid to protein ratio and crosslinkings of lysine residues." Chem.Phys.Lipids.

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      1989 Annual Research Report
  • [Publications] Hiroshi Ohguro: "Functional heterogeneity of βγ-subunit of frog transducin." Comp.Biochem.Physiol.

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  • [Publications] Hiroshi Ohguro: "Specific βγ-subunit of bovine transducin stimulates ADP-ribosylation of the α-subunit by pertussis toxin." Biochem.Biophys.Res.Commun.

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  • [Publications] Toshiyuki Okano: "Purification of cone visiual pigments from chicken retina." Biochemistry. 28. 8848-8856 (1989)

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      1989 Annual Research Report
  • [Publications] 七田芳則: "部位特異的変異誘導により何が分かるか-バクテリオロドプシンの光反応サイクル" ビタミン. 63. 604-606 (1989)

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      1989 Annual Research Report
  • [Publications] Achla Trehan: "On retention of configuration of rhodopsin analogs derived from three dicis retinal isomers." J.Bioorg.Chem.

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      1989 Annual Research Report
  • [Publications] 吉澤透: "視物質とビタミンA" ビタミン. 64. 95-98 (1989)

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  • [Publications] 深田吉孝: "視細胞における情報変換 シリーズ「分子生物学の進歩」、第11巻「分子神経生物学」(御子柴克彦、野田正治編集)" 丸善, 17 (1989)

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  • [Publications] 桑田治: "視覚受容の分子機構 蛋白質 核酸 酵素(別冊)、「神経生化学」" 共立出版, 11

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  • [Publications] 前田章夫: "解説:視覚の分子メカニズム 蛋白質 核酸 酵素(別冊)" 共立出版, 7 (1989)

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  • [Publications] 前田章夫: "レチナール蛋白質におけるエネルギー変換機構 蛋白質 核酸 酵素(別冊)" 共立出版, 12 (1989)

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  • [Publications] 前田章夫: "光による機能発現 生物物理の最前線(日本生物物理学会編)" 講談社,

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  • [Publications] Toru Yoshizawz: "Visual transduction process in vertebrate photo-receptor cell.Physiology and Pharvacology of Transmembrane Signalling,(ed.T.Segawa,M.Endo,M.Ui and K.Kurihara)" Elsevier Science Publishers BV, 9 (1989)

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  • [Publications] 吉澤透: "ロドプシンにおける光受容機構;光励起ロドプシンに誘起される初期反応 蛋白質 核酸 酵素(別冊)" 共立出版, 13 (1989)

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      1989 Annual Research Report
  • [Publications] Toru Yoshizawa: "Spectra and structures of photorhodopsin and bathorhodopsin:Studied by picosecond laser photolysis.Photobiology:The Science and its Applications." Plenum Press., 10

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  • [Publications] Hideki Kandori: Photochem.Photobiol.48. 93-97 (1988)

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  • [Publications] Yoshinori Shichida: Biochemistry. 27. 6495-6499 (1988)

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      1988 Annual Research Report
  • [Publications] Yoshinori Shichida: FEBS Lett.236. 333-336 (1988)

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  • [Publications] Toru Yoshizawa: "Molecular Physiology of Retinal Protein"(ed.T.Hara)Yamada Science Foundation,Tokyo,Japan. 49-54 (1988)

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      1988 Annual Research Report
  • [Publications] Masahiro Ariki: "Molecular Physiology of Retinal Proteins"(ed.T.Hara)Yamada Science Foundation,Tokyo,Japan. 355-356 (1988)

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      1988 Annual Research Report
  • [Publications] Yasushi Imamoto: "Molecular Physiology of Retinal Proteins"(ed.T.Hara)Yamada Science Foundation,Tokyo,Japan. 361-362 (1988)

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      1988 Annual Research Report
  • [Publications] Osamu Kuwata: "Molecular Physiology of Retinal Proteins"(ed.T.Hara)Yamada Science Foundation,Tokyo,Japan. 379-380 (1988)

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      1988 Annual Research Report
  • [Publications] Hideki Kandori: "Molecular Physiology of Retinal Proteins"(ed.T.Hara)Yamada Science Foundation,Tokyo,Japan. 383-384 (1988)

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      1988 Annual Research Report
  • [Publications] Yoshinori Shichida: "Molecular Physiology of Retinal Proteins"(ed.T.Hara)Yamada Science Foundation,Tokyo,Japan. 385-386 (1988)

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      1988 Annual Research Report
  • [Publications] Yoshitaka Fukada: "Molecular Physiology of Retinal Proteins"(ed.T.Hara)Yamada Science Foundation,Tokyo,Japan. 397-398 (1988)

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      1988 Annual Research Report
  • [Publications] Toyoaki Akino: "Molecular Physiology of Retinal Proteins"(ed.T.Hara)Yamada Science Foundation,Tokyo,Japan. 399-400 (1988)

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      1988 Annual Research Report
  • [Publications] Masayoshi Ito: J.Nutr.Sci.Vitaminol.34. 641-646 (1988)

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      1988 Annual Research Report
  • [Publications] Hideki Kandori: Photochem.Photobiol.49. 181-184 (1989)

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      1988 Annual Research Report
  • [Publications] Yoshinori Shichida: Exp.Eye Res.48. 281-293 (1989)

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      1988 Annual Research Report
  • [Publications] Yoshitaka Fukada: J.Biol.Chem.(1989)

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      1988 Annual Research Report
  • [Publications] Hideki Kandori: Biochemistry.

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      1988 Annual Research Report
  • [Publications] 七田芳則: "LUMINIS" 中西印刷, 20-26 (1988)

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  • [Publications] 吉澤透: "新生理科学体系 第9巻感覚の生理学 V.視物質" 医学書院, 76-89 (1989)

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      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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