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The Mechanism of Abortion caused by Arboviruses in Domestic Animals and the Ecology of the Viruses

Research Project

Project/Area Number 63304027
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Applied veterinary science
Research InstitutionFaculty of Veterinary Medicine, Hokkaido University

Principal Investigator

HASHIMOTO Nobuo  Hokkaido University, Faculty of Veterinary Medicine, Professor, 獣医学部, 教授 (60082103)

Co-Investigator(Kenkyū-buntansha) MIURA Yasuo  National Institute of Animal Health, Tskuba, Investigator, 九州支場, 室長
NAKANO Minoru  Kitazato University, School of Veterinary Medicine and Animal Sciences, Associat, 獣医畜産学部, 助教授 (30050488)
TAKASHIMA Ikuo  Hokkaido University, Faculty of Veterinary Medicine, Associate Professor, 獣医学部, 助教授 (30002083)
OHSHIMA Kani-ichi  Iwate University, Faculty of Agriculture, Professor, 農学部, 教授 (20003733)
GOTO Hitoshi  Obihiro University of Agriculture and Veterinary Medicine, Professor, 畜産学部, 教授 (20003072)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥11,300,000 (Direct Cost: ¥11,300,000)
Fiscal Year 1989: ¥5,700,000 (Direct Cost: ¥5,700,000)
Fiscal Year 1988: ¥5,600,000 (Direct Cost: ¥5,600,000)
KeywordsArbovirus / Abortion / Viral abortion / Abortion in domestic animals / Congenital abnormality / Mechanism of congenital abnormality caused by arbovirus / Viral congenital abnormality / Ecology of arbovirus / ウィルス性異常産 / ウィルス性奇形の発現機序 / 節足動物媒介性ウィルス / 3.アルボウイルス / 家畜異常産ウイルスの生態学 / アルボウイルス性家畜異常産の発生機序 / アルボウイルス性異常産の疫学 / ウイルス性奇型の発現機序
Research Abstract

The mechanism of abortion in domestic animals caused byarboviruses, Japanese encephalitis virus (JEV), Getah virus (GTV), Akabane virus (AKV), Chuzan virus (CZV) and bovine viral diarrhoea-mucosal disease virus (BVD-MDV) was studied by virological, pathological and epizzotiological examinations.
1) Outbreaks of abortion and stillbirth caused by JEV were observed in swine population in Hokkaido. JE antibody positive farms were found at the same site in negative farms in 3 years continuously. This result indicates that the JEV was maintained in a distinct endemic focus.
2) Vertical transmission of JE virus in Aedes japonicas was demonstrated with a minimum rate of 0.7%.
3) Dot-immunobinding assay has been evaluated as a useful method for the detection of anti-GTV antibody in horses.
4) Pathological studies were performed on bovine Akabane disease occurred in Iwate. Arthrogriposis was recognized in 14 out of 70 cattle involved in the occurrence.
5) AKV was isolated from the biting midge, Culicooides oxystoma, collected in a cowshed in Kagoshima.
6) Chuzan virus classified as a new member of the Playah subgroup of the genus Orbivirus was isolated from healthy calves and from Culiooides oxystoma. The virus caused epidemic of congenital abnormalities of calves characterized by the hydroencephally-cerebellar hydroplasia which occurred in Kyushu.
7) When cattle persistently infected with non-cytopathic BVD-MDV were challenged to cytopathid strain, some of them developed mucosal disease and morbund. All control cattle showed transit fever but no diarrhea, and recovered from infection.
8) Two newborn calves with congenital malformation by in utero infection with BVD-MDV also showed ataxia and blindness. At autopsy, cerebellar hypoplasia and reduction insize of the optic nerves were observed in both cases in addition to severe hydrocephalus in one case.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (37 results)

All Other

All Publications (37 results)

  • [Publications] Takashima,I.,Hashimoto,N.,Watanabe,T.and Rosen,L.: "Mosquito collection in endemic areas of Japanese encephalitis in Hokkaido,Japan" Jpn.J.Vet.Sci.51. 947-953 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takashima,I.and Rosen,L.: "Horizontal and vertical transmission of Japanese encephalitis virus by Aedes Japonics(Diptera:Culicidae)" J.Med.Entmol.26. 454-458 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takashima,I.Watanabe,T.,Ouchi,N.and Hashimoto,N.: "Ecological studies of Japanese encephalitis virus in Hokkaido:Interepidemic outbreaks of swine abortion and evidnece for the virus to overwinter locally" Amer.J.Trop.Med.Hyg.38. 420-427 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sugiura,Y.,Ohta,C.and Goto,H.: "A dot-immunobinding assay for the detection of antibody to Getah virus in horses" Australian Vet.J.66. 340-341 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kurogi,H.,Akiba,K.,Inaba,Y.and Matsumoto,M.: "Isolation of Akabane virus from the biting madge Culicoides oxystoma in Japan" Vet.Microbiol. 15. 243-248 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miura,Y.,Goto,Y.,Kubo,M.and Kono,Y.: "Isolation of Chzan viurs,a new member of the Palyam subgroup of the genus Orbivirus,from cattle and Culicoides oxystoma in Japan" Amer.J.Vet.Res.49. 2022-2025 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miura,Y.,Goto,Y.,Kubo,M.and Kono,Y.: "Pathogenicity of Chuzan virus,a new member of the Palyam subgroup of genus Orbivirus from cattle" Jpn.J.Vet.Sci.50. 632-637 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大島寛一、岡田幸助、沼宮内茂、清宮幸男、吉田欣哉、伊藤博: "ウシのアカバネ病に関する病理学的研究-1985年86年岩手県発生例を中心として-" 成長J.of Growth. 26. 113-128 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 清宮幸男、伊藤博、及川団、小川富男、大池裕治、大島寛一、岡田幸助: "牛ウイルス性下痢、粘膜病ウイルスの胎内感染に起因する先天性異常を有する新生子牛2例の疫学および病理学的観察" 日本獣医師会雑誌. 41. 725-730 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sumizu,M.,Satou,K.,Nishioka,N.,Yoshino,T.,Momotani,E.and Ishikawa,Y.: "Serological characterization of virusese isolated from experimental mucosal disease" Vet.Microbiol.19. 13-21 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu,M.,Murakami,S.and Satou,K.: "Serological comparison of cytopathogenic and non-cytopathogenic bovine viral diarrhea-mucosal disease virus isolated from cattle with mucosal disease" Jpn.J.Vet.Sci.51. 157-162 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu,M.,Watanabe,H.,Satou,K.and Murakami,S.: "Antigenic diversity of bovine virua diarrhea-mucosal disease(BVD MD) viruses recently isolated from persistenly infected calltle and mocosal disease,and serologic survey on bovine sera using antigenically dirrent BVD-MD biruses" Jpn.J.VEt.Sci.51. 1115-1122 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takashima, I., Hashimoto, N., Watanabe, T.and Rosen, L.: "Mosquito collection in endemic areas of Japanese encephalitis in Hokkaido, Japan" Jpn. J. Vet. Sci.51. 947-953 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takashima, I and Rosen, L.: "Horizontal and vertical transmission of Japanese encephalitis virus by Aedes japonicas (Diptera:Culicidae)" J. Med. Entmol.26. 454-458 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takashima, I., Watanabe, T., Ouchi, N. and Hashimoto, N.: "Ecological studies of Japanese encephalitis virus in Hokkaido: Interepidemics outbreaks of swine abortion and evidence for the virus to overwinter locally" Amer. J. Trop. Med. Hyg.38. 420-427 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sugiura, Y., Ohta, C. and Goto, H.: "A DOT-immunobinding assay for the detection of antibody to Getah virus in horses" Australian Vet.J.66. 340-341 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kurogi, H., Akiba, K., Inaba, Y. and Matsumoto, M.: "Isolation of Akabane virus from the biting madge Culicoides oxystoma in Japan" Vet. Microbiol.15. 243-238 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miura, Y., Goto, Y. Kubo, M. and Kono, Y.: "Isolation of Chuzan virus, a new member of the Palyam subgroup of the genus Orbivirus from cattle and Culicoides oxystoma in Japan" Amer. J. Vet. Res.49. 2022-2025 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miura, Y., Goto, Y., Kubo, M. and Kono, Y.: "Pathogenicity of Chuzan virus, a new member of the Palyam subgroup of genus Orbivirus from cattle" Jpn. J. Vet. Sci.50. 632-637 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohshima, K., Okada, K., Numakunai, S., Seimiya, Y., Yoshida, K. and Ito, H.: "Pathologic studies on bovine Akabane disease occurred in Iwate Prefecture in 1985 and 1986" J. of Growth. 26. 113-138 (1987 (in Japanese))

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Seimiya, Y., Ito, H., Oikawa, M., Obara, T., Oh-ike, Y., Ohshima, K.and Okada, K.: "Epizootiology and pathology of congenital malformations in two newborn calves caused by intrauterine infection with bovine viral diarrheamucosal disease virus" Jpn J. Vet. Med.41. 725-730 (1988 (in Japanese))

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu, M., Satou, K., Nishioka, N., Yoshino, T., Momotani, E. and Ishikawa, Y.: "Serological characterization of viruses isolated from experimental mucosal disease" Vet. Microbio.19. 13-21 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu, M., Murakami, S. and Satou, K.: "Serological comparison of cytopathogenic and non-cytopathogenic bovine viral diarrea-mucosal disease virus isolated from cattle with mucosal disease" Jpn. J. Vet. Sci.51. 157-162 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu, M., Watanabe, H., Satou, K. and Murakami, S.: "Antigenic diversity of bovine viral diarrhea-mucosal disease (BVD-MD) viruses recently isolated from persistently infected cattle and mucosal disease, and serologic survey on bovine sera using antigenically different BVD-MD viruses" Jpn. J. Vet. Sci.51. 1115-1122 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu, M.: "Transplacetal infection of bovine viral diarrhea-mucosal disease (BVD-MD) : on the persistent infection" Dosei Kyokai Kaiho. 21. 13-19 (1988 (in Japanese))

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takashima,I.,Hashimoto,N.,Watanabe,T.and Rosen,L.: "Mosquito collection in endemic areas of Japanese encephalitis in Hokkaido,Japan" Jpn.J.Vet.Sci.51. 947-953 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takashima,I.and Rosen,L.: "Horizontal and vertical transmission of Japanese encephalitis virus by Aedes japonicus(Diptera:culicidae)" J.Med.Entomol.26. 454-458 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sugiura,Y.,Ohta,C.and Goto,H.: "A dot-immunobinding assay for the detection of antibody to Getah virus in horses" Australian Vet.J.66. 340-341 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大島寛一、岡田幸助、沼宮内茂、清宮幸男、吉田欣哉、伊藤博: "ウシのアカバネ病に関する病理学的研究-1985年86年岩手県発生例を中心として-" 成長(J.of Growth). 26. 113-128 (1987)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kurogi,H.,Akiba,K.,Inaba,Y.and Matsumoto,M: "Isolation of Akabane virus from the biting madge Culicoides oxystoma in Japan" Veterinary Microbiology. 15. 243-248 (1987)

    • Related Report
      1989 Annual Research Report
  • [Publications] Shimizu,M.,Satou,K.,Nishioka,N.,yoshio,t.Momotani,E.and Ishikawa,Y.: "Serological Characterization of Viruses isolated from experimental mucosal disease" Veterinary Microbiology. 19. 13-21 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takashima,Ikuo.,et al.: Am. J.Trop.Med.Hyg.38. 420-427 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Takashima,I.;Hashimoto,N.: 22nd Joint Working Conference on Viral Disesese,Japan-US Coopereative Medical Science Program. 22. 15-16 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Motohide,Y.,et al: Microbiol. Immunol.32. 351-361 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kurogi,H.,et al.: Veterinary Microbiology. 15. 243-248 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Gotoh,H.,et al.: Australian Veterinary Journal. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Sugiura,Y.,et al.: Australian Veterinary Journal. (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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