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Mechanism of Latency and its Control in Herpesvirus Infections

Research Project

Project/Area Number 63304037
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Virology
Research InstitutionKyushu University

Principal Investigator

MORI Ryoichi  Kyushu University, Faculty of Medicine, Professor, 医学部, 教授 (50038692)

Co-Investigator(Kenkyū-buntansha) FURUKAWA Toru  Kanazawa Medical University, Faculty of Medicine, Professor, 教授 (00148157)
MINAMISHIMA Youichi  Miyazaki Medical College, Faculty of Medicine, Professor, 教授 (80041284)
TAKAHASHI Michiaki  Osaka University, Research Institute for Microbial Diseases, Professor, 微生物病研究所, 教授 (50029758)
SHIMIZU Yoshinobu  Tohoku University, Faculty of Dentistry, Associate Professor, 歯学部, 助教授 (20005078)
NII Shiro  Okayama University, Faculty of Medicine, Professor, 医学部, 教授 (40029757)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥10,300,000 (Direct Cost: ¥10,300,000)
Fiscal Year 1990: ¥3,000,000 (Direct Cost: ¥3,000,000)
Fiscal Year 1989: ¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1988: ¥4,000,000 (Direct Cost: ¥4,000,000)
KeywordsHerpesvirus / Herpes simplex virus / Varicella-zoster virus / Cytomegalovirus / HHV-6 / Latent infection / Reactivation / HHVー6 / 水痘・帯状ヘルペスウイルス
Research Abstract

The mechanisms of latent infection and reactivation from latency of herpesviruses, especially herpes simplex virus (HSV), varicella zoster virus(VZV), cytomegalovirus (CMV) and human herpes virus No.6 (HHV-6) were investigated as follows;
Immune defense mechanism against HSV infection was analysed using SCID and nude mice. One of these studies showed that HSV could latently infect in these immunocompromised mice and it was reactivated by pregnancy (Mori).
To distinguish HSV-1 from HSV-2 infection, type-specific DNA regions were searched for and the basic conditions for DNA diagnosis of them were determined (Kurimura).
A comparison between strains of HSV-1 was performed as for the ability of latent infection and reactivation (Nii).
The nervous system as target site of HSV infection and latency was analysed in detail (Kurata).
The mode of latent infection and reactivation of HHV-6 and VZV was analysed in vitro and in vivo. For this purpose, the existence of these viruses in human was examined by PRC. The results showed that HHV-6 DNA was detected both in CD4^+ lymphocytes and in macrophages during the acute phase of exanthem subitum and it was detected only in macrophages during the recovery phase of the disease (Tskahashi).
The target organs and the mode of latent infection of human CMV were investigated by PCR (Furukawa).
The titer of complement-dependent neutralizing antibodies against HCMV was examined during pregnancy in which HCMV become to be excreted from the cervix of the uterus and the influence of their change on reactivation of the virus was discussed (Tanaka).
The significance of CMV infection in Sjogren's syndrome was examined by analysing autoimmune antibodies (Shimizu).
Molecular analysis of lethal and persistent infections was performed by using attenuated mouse CMV (Minamishima).

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report

Research Products

(123 results)

All Other

All Publications (123 results)

  • [Publications] Hidaka,Y.Sakuma,S.Kumano,Y.minagawa,H.Mori,R.: "Characterization of glycoprotein C-negative mutants of herpes simplex virus type 1 isolated from a patient with keratitis" Arch.Virol.113. 195-207 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kumano,Y.Yamoto,M.Inomata,H.Sakuma,S.Hidaka,Y.Minagawa,H.Mori,R.: "Recurrent Herpetic Keratitis:Failure to Detect Herpes simplex Virus Infection Using the Syva MicroTrak^<TM> HSV1/HSV2 Direct Specimen Identification/Typing Test" Ophthalmologica. 201. 169-173 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Li,Yu.-Yu.Hidaka,Y.Kino,Y.Mori,R.: "Seroepidemiology of Herpes Simplex Virus Type 1 in Yanji,Jilin,China" Microbiol.Immunol.34. 551-555 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arao,Y.Yoshida,M.Bai,Z.Kori,Y.Nakatsukasa,A.Takei,Y.Aoji,K.Yamada,M.Uno,F.Miyoshi,K.Nii,S.: "Detection of Varicella-Zoster Virus DNA by Field-Inversion Gel Electrophoresis" Microbiol.Immunol.34. 269-282 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshida,M.Uno,F.Yamanishi,.K.Ikuta,K.Kurata,T.Nii,S.: "Electron microscopic study of human herpesvirus-6(HHV-6)" in Electron Microscopy. 3. 384-385 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nii,S.Yoshida,M.Uno,F.Kurata,T.Ikuta,K.Yamanishi,K.: "Replication of Human Herpesvirus 6(HHV-6):Morphological Aspects" in Immunobiology and Prophylaxis of Human Herpesvirus Infections. 19-28 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nii,S.Yoshida,M.Uno,F.Bai Z.Arao,Y.Yamada,M.Kurata,T.Ikuta,K.Yamanishi,K.: "Electron microscopic observations of human herpesvirus-6" in Recent Development of Electron Microscopy.1990. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arao,Y.Hatano,A.Yamada,M..Uno,F.Nii,S.: "Reactivatable latency of three avirulent strains of herpes simplex virus type 1 after intranasal inoculation in mice" Acta Med,Okayama. 45. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arao,Y.Hatano,A.Yamada,M.Uno,F.Nii,S.: "Neurovirulent strains of herpes simplex virus type 1 are not necessarily competent for reactivatable latency" Acta Med,Okayama. 45. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 清水 義信: "口腔ヘルペス群ウイルス感染と免疫" 歯科ジャーナル. 31. 990-998 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamada,O.Matsumoto,T.Nakashima,M.Hagari,S.Kamahora,T.Ueyama,H.Kishi,Y.Uemura,H.Kurimura,T.: "A new method for extracting DNA or RNA for polymerase chain reaction" J.Virol.Methods. 27. 203-210 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 栗村 敬: "HIV感染におけるHHV-6の関与" 臨床免疫. 22. 446-448 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 松本 俊也、釜洞 俊雄、栗村 敬: "単純ヘルペスウイルス1型、2型特異的識別DNA診断法" 臨床とウイルス. 18. 49-52 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kurata,T.Iwasaki,T.Sata,T.Wakabayashi,T.Yamaguchi,K.Okuno T.Takei,Y.: "Viral pathology of human herpesvirus 6 infection" in Immunobiology and prophylaxis of human Herpesvirus Infections. 39-47 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ishij,K.Kurata,T.Nomura,Y.: "Experiments on herpes simplex viral infections of the facial nerve in the tympanic cavity" Eur.Arch.Otorhinolaryngol.247. 165-167 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ito,M.Kamiya,T.Kitamura,K.Sakurai,M.Ihara,T.kamiya,H.Kurata,T.: "Rapid diagnosis of varicella zoster virus(VZV)infection in immunocompromized children by derect immunofluorescence stainning using mouse monoclonal antibodies" Mie Med.J.40. 81-84 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujiwara,Y.Yanagihara,N.Kurata,T.: "Middle ear mucosa in Ramsay Hunt syndrome" Ann Otol,Rhinol & Laryngol. 99. 359-362 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shimidbauer,M.Budka,H.Pilz,P.Kurata,T.Hondo,R.: "Presence,distribution,and spread of productive varicella-zoster virus(VZV)infection in nervous tissues" Acta Neuropathol. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okuno,T.Shao,H.Asada,H.Shiraki,K.Takahashi,M.Yamanishi,K.: "Analysis of a glycoprotein of human herpesvirus6(HHV-6)using monoclonal antibodies" Virology. 176. 625-628 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okuno,T.Higashi,K.Shiraki,K.Yamanishi,K.Takahashi,M.Kokado Y.Ishibasi,M.Takahara,S.Sonoda,T.Tanaka,K.Bada,K.Yabuuchi,H.Kurata,T.: "Human herpesvirus 6 infections in renal transplantation" Transplantation. 49. 519-522 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kido,S.Kondo,K.Kondo,T.Morishima T.Takahashi,M.Yamanishi,K.: "Detection of human herpesvirus 6 DNA in throat swabs by polymerase chain reaction" J.Med.Virol.32. 139-142 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kondo,K.Hayakawa,Y.Mori,H.Sato,S.Kondo,T.Takahashi,K.Minamishima,Y.Takahashi,M.Yamanishi,K.: "Detection by polymerase chain reaction amplification of human herpesvirus 6 DNA in peripheral blood of patients with exanthem subitum" J.Clin.Microbiol.28. 970-974 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shiraki,K.Mukai,T.Okuno T.Yamanishi,K.Takahashi,M.: "Physicochemical charactorization of human herpesvirus 6 infectivity" J.Gen.Vorol.(1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kondo,K.Kondo,T.Okuno,T.Takahashi,M.Yamanishi,K.: "Latant infection of human herpesvirus 6(HHV-6)in human monocyte/macrophages" J.Gen.Virol.(1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kido,S.Ozaki,T.Asada,H.Higashi,K.Kondo,K.Hayakawa,Y.Morishima,T.Takahashi,M.Yamanishi,K.: "Detection of varicella-zoster virus(VZV)DNA in clinical samples from patients with VZV by the polymerase chain reaction" J.Clin.Microbiol.29. 76-79 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takahashi,M.Baba,K.Horiuchi,K.Kamiya,H.Asano,Y.: "A live varicella vaccine" in Immunobiology and Prophylaxis of Human herpesvirus Infections. 49-58 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ibusuki,K.Minamishima,Y.: "Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections" Nat.Immun.Cell Growth Regul.9. 121-128 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kumura,K.Ibusuki,K.Minamishima,Y.: "Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus" Virology. 175. 572-574 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Xu-Bin: "β_2 microglobulin Receptor is Located on a Major Human Cytomegalovirus Protein 65 kDa Sharing the Site of IgG Fc Receptor." J.Kanazawa Med.Univ.15. 142-148 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 村山 次哉、古川 宣、地崎 赴美子、館野 恵美子、平井 莞二、: "PCR法のサイトメガロウイルス診断への応用" 臨床とウイルス. 18. 345-348 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 古川 宣: "サイトメガロウイルスワクチン" 日本臨床. 48. 743-748 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Lopez,C.Mori,R.Roizman,B.Whitley,R.J.,Edt.: "Immunobiology and Prophylaxis of Human Herpesvirus Infections" Plenum Pless,New York and London, 296 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hidaka, Y. Sakuma, S. Kumano, Y. Minagawa, H. Mori, R.: "Characterization of glycoprotein C-negative mutants of herpes simplex virus type 1 isolated from a patient with keratitis" Arch. Virol. 113. 195-207 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kumano, Y. Yamamoto, M. Inomata, H. Sakuma, S. Hidaka, Y. Minagawa, H. Mori, R.: "Recurrent Herpetic Keratitis: Failure to Detect Herpes simplex Virus Infection Using the Syva MicroTraK^<TM> HSV1/HSV2 Direct" Ophthalmologica. 201. 169-173 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Li, Yu-Yu. Hidaka, Y. Kino, Y. Mori, R.: "Seroepidemiology of Herpes Simplex Virus Type in Yanji, Jilin, China" Microbiol. Immunol.34. 269-282 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arao, Y. Yoshida, M. Bai, Z. Kori, Y. Nakatsukasa, A. Takei, Y. Aoji, K. Yamada, M. Uno, F. Miyoshi, K. Nii, S.: "Detection of Varicella-Zoster Virus DNA by Field-Inversion Gel Electrophoresis" Microbiol. Immunol.34. 269-282 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yoshida, M. Uno, F. Yamanishi, K. Ikuta, K. Kurata, T. Nii, S.: "Electron microscopic study of human herpesvirus-6 (HHV-6)" Electron Microscopy. 3. 384-385 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nii, S. Yoshida, M. Uno, F. Kurata, T. Ikuta, K. Yamanishi, K.: "Replication of Human Herpesvirus 6 (HHV-6): Morphological Aspects" Immunobiology and Prophylaxis of Human Herpesvirus Infections. 19-28 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Nii, S. Yoshida, M. Uno, F. Bai, Z. Arao, Y. Yamada, M. Kurata, T. Ikuta, K. Yamanishi, K.: Recent Development of Electron Microscopy 1990. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arao, Y. Hatano, A. Yamada, M. Uno, F. Nii, S.: "Reactivatable latency of three avirulent strains of herpes simplex virus type 1 after intranasal inoculation in mice" Acta Med, Okayama. 45. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Arao, Y. Hatano, A. Yamada, M. Uno, F. Nii, S: "Neurovirulent strains of herpes simplex virus type 1 are not nevessarily competent for reactivatable latency" Acta Med, Okayama. 45. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamada, O. Matsumoto, T. Nakashima, M. Hagari, S. Kamahora, T. Ueyama, H. Kishi, Y. Uemura, H. Kurimura, T.: "A new method for extracting DNA or RNA for polymerase chain reaction" J. Virol. Methods. 27. 203-210 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kurata, T. Iwasaki, T. Sata, T. Wakabayashi, T. Yamaguchi, K. Okun, T. Takei, Y.: "Viral pathology of human herpesvirus 6 infection" Immunobiology and prophylaxis of human Herpesvirus Infections. 39-47 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ishii, K. Kurata, T. Nomura, Y.: "Experiments on herpes simplex viral infections of the facial nerve in the tympanic cavity" Eur. Arch. Otorhinolaryngol. 247. 165-167 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ito, M. Kimiya, T. Kitamura, K. Sakurai, M. Ihara, T. Kimiya, H. Kurata, T.: "Rapid diagnosis of varicella zoster virus(VZV) infection in immunocompromized children by direct immunofluorescence staining using mouse monoclonal antibodies" Mie Med. J.40. 81-84 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujiwara, Y. Yanagihara, N. Kurata, T.: "Middle ear mucosa in Ramsay Hunt syndrome" Ann Otol, Rhinol & Laryngol. 99. 359-362 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shimidbauer, M. Budka, H. Pilz, P. Kurata, T. Honda, R.: "Presence, distribution, and spread of productive varicella-zoster virus (VZV) infection in nervous tissues" Acta Neuropathol. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okuno, T. Shao, H. Asada, H. Shiraki, K. Takahashi, M. Yamanishi, K.: "Analysis of a glycoprotein of human herpesvirus 6 (HHV-6) using monoclonal antibodies" Virology. 176. 519-522 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Okuno, T. Higashi, K. Shiraki, K. Yamanishi, K. Takahash, M. Kokado, Y. Ishibashi, M. Takahara, S. Sonoda, T. Tanaka, K. Baba, K. Yabuuchi, H. Kurata, T.: "Human herpesvirus 6 infections in renal transplantation" Transplantation. 49. 519-522 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kido, S. Kondo, K. Kondo, T. Morishima, T. Takahashi, M. Yamanishi, K.: "Detection of human herpesvirus 6 DNA in throat swabs by polymerase chain reaction" J. Med. Virol.32. 139-142 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kondo, K. Hayakawa, Y. Mori, H. Sato, S. Kondo, T. Takahashi, K. Minamishima, Y. Takahashi, M. Yamanishi, K.: "Detection by polymerase chain reaction amplification of human herpesvirus 6 DNA in peripheral blood of patients with exanthem subitum" J.Clin. Microbiol.28. 970-974 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Shiraki, K. Mukai, T. Okuno, T. Yamanishi, K. Takahashi, M.: "Physicochemical characterization of human herpesvirus 6 infectivity" J.Gen. Virol. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kondo, K. Kondo, T. Okuno, T. Takahashi, M. Yamanishi, K.: "Latent infection of human herpesvirus 6 (HHV-6) in human monocyte/macrophages" J. Gen. Virol.(1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kido, S. Ozaki, T. Asada, H. Higashi, K. Kondo, K. Hayakawa, Y. Morishima, T. Takahashi, M. Yamanishi, K.: "Detection of varicella-zoster virus(VZV) DNA in clinical samples from patients with VZV by the polymerase chain reaction" J. Clin. Microbiol.29. 76-79 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takahashi, M. Baba, K. Horiuchi, K. Kamiya, H. Asano, Y.: "A live varicella vaccine" Immunobiology and Prophylaxis of Human herpesvirus Infections. 49-58 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ibusuki, K. Minamishima, Y.: "Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections" Nat. Immun. Cell Growth Rgul.9. 121-128 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kumura, K. Ibusuki, K. Minamishima, Y.: "Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus" Virology. 175. 572-574 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Xu-Bin: "beta_2 microglobulin Receptor is Located on a Major Human Cytomegalovirus Protein 65 kDa Sharing the Site of IgG Fc Receptor" J. Kanazawa Med. Univ.15. 142-148 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Lopez, C. Mori, R. Roizman, B. Whitley, R.J., Edt.: "Immunobiology and Prophylaxis of Human Herpesvirus Infections" Immunobiology and Prophylaxis of Human Herpesvirus Infections Plenum Pless, New York and London. 296. (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hidaka,Y.Sakuma,S.Kumano,Y.Minagawa,H.<Mori,R.>___ー: "Characterization of glycoprotein Cーnegative mutants of herpes simplex virus type 1 isolated from a patient with keratitis" Arch.Virol.113. 195-207 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kumano,Y.Yamamoto,M.Inomata,H.Sakuma,S.Hidaka,Y.Minagawa,H.<Mori,R.>___ー: "Recurrent Herpetic Keratitis: Failure to Detect Herpes simplex Virus Infection Using the Syva MicroTrak^<TM> HSV1/HSV2 Direct Specimen Identification/Typing Test" Ophthalmologica. 201. 169-173 (1990)

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      1990 Annual Research Report
  • [Publications] Li,Yu.ーYu.Hidaka,Y.Kino,Y.<Mori,R.>___ー: "Seroepidemiology of Herpes Simplex Virus Type 1 in Yanji,Jilin,China" Microbiol.Immunol.34. 551-555 (1990)

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      1990 Annual Research Report
  • [Publications] Arao,Y.Yoshida,M.Bai,Z.Kori,Y.Nakatsukasa,A.Takei,Y.Aoji,K.Yamada,M.Uno,F.Miyoshi,K.<Nii,S.>___ー: "Detection of VaricellaーZoster Virus DNA by FieldーInversion Gel Electrophoresis" Microbiol.Immunol.34. 269-282 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yoshida,M.Uno,F.Yamanishi,.K.Ikuta,K.Kurata,T.<Nii,S.>___ー: "Electron microscopic study of human herpesvirusー6(HHVー6)" <in>___ー Electron Microscopy. 3. 384-385 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Nii,S.Yoshida,M.Uno,F.Kurata,T.Ikuta,K.Yamanishi,K.: "Replication of Human Herpesvirus 6(HHVー6):Morphological Aspects" <in>___ー Immunobiology and Prophylaxis of Human Herpesvirus Infections. 19-28 (1990)

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      1990 Annual Research Report
  • [Publications] Nii,S.Yoshida,M.Uno,F.Bai Z.Arao,Y.Yamada,M.Kurata,T.Ikuta,K.Yamanishi,K.: "Electron microscopic observations of human herpesvirusー6" <in>___ー Recent Development of Electron Microscopy・1990. (1990)

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      1990 Annual Research Report
  • [Publications] Arao,Y.Hatano,A.Yamada,M.Uno,F.<Nii,S.>___ー: "Reactivatable latency of three avirulent strains of herpes simplex virus type 1 after intranasal inoculation in mice" Acta Med,Okayama. 45. (1991)

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      1990 Annual Research Report
  • [Publications] Arao,Y.Hatano,A.Yamada,M.Uno,F.<Nii,S.>___ー: "Neurovirulent strains of herpes simplex virus type 1 are not necessarily competent for reactivatable latency" Acta Med,Okayama. 45. (1991)

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      1990 Annual Research Report
  • [Publications] <清水 義信>___ー: "口腔ヘルペス群ウイルス感染と免疫" 歯科ジャ-ナル. 31. 990-998 (1990)

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      1990 Annual Research Report
  • [Publications] Yamada,O.Matsumoto,T.Nakashima,M.Hagari,S.Kamahora,T.Ueyama,H.Kishi,Y.Uemura,H.<Kurimura,T.>___ー: "A new method for extracting DNA or RNA for polymerase chain reaction" J.Virol.Methods. 27. 203-210 (1990)

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      1990 Annual Research Report
  • [Publications] <栗村 敬>___ー: "HIV感染におけるHHVー6の関与" 臨床免疫. 22. 446-448 (1990)

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      1990 Annual Research Report
  • [Publications] 松本 俊也、釜洞 俊雄、<栗村 敬>___ー: "単純ヘルペスウイルス1型、2型特異的識別DNA診断法" 臨床とウイルス. 18. 49-52 (1990)

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      1990 Annual Research Report
  • [Publications] Kurata,T.Iwasaki,T.Sata,T.Wakabayashi,T.Yamaguchi,K.Okuno T.Takei,Y.: "Viral pathology of human herpesvirus 6 infection" <in>___ー Immunobiology and prophylaxis of human Herpesvirus Infections. 39-47 (1990)

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      1990 Annual Research Report
  • [Publications] Ishii,K.<Kurata,T.>___ーNomura,Y.: "Experiments on herpes simplex viral infections of the facial nerve in the tympanic cavity" Eur.Arch.Otorhinolaryngol.247. 165-167 (1990)

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      1990 Annual Research Report
  • [Publications] Ito,M.Kamiya,T.Kitamura,K.Sakurai,M.Ihara,T.Kamiya,H.<Kurata,T.>___ー: "Rapid diagnosis of varicella zoster virus(VZV)infection in immunocompromized children by derect immunofluorescence stainning using mouse monoclonal antibodies" Mie Med.J.40. 81-84 (1990)

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      1990 Annual Research Report
  • [Publications] Fujiwara,Y.Yanagihara,N.<Kurata,T.>___ー: "Middle ear mucosa in Ramsay Hunt syndrome" Ann Otol,Rhinol & Laryngol. 99. 359-362 (1990)

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      1990 Annual Research Report
  • [Publications] Shimidbauer,M.Budka,H.Pilz,P.<Kurata,T.>___ーHondo,R.: "Presence,distribution,and spread of productive varicellaーzoster virus(VZV)infection in nervous tissues" Acta Neuropathol. (1991)

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      1990 Annual Research Report
  • [Publications] Okuno,T.Shao,H.Asada,H.Shiraki,K.<Takahashi,M.>___ーYamanishi,K.: "Analysis of a glycoprotein of human herpesvirus6(HHVー6)using monoclonal antibodies" Virology. 176. 625-628 (1990)

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      1990 Annual Research Report
  • [Publications] Okuno,T.Higashi,K.Shiraki,K.Yamanishi,K.<Takahashi,M.>___ーKokado Y.Ishibashi,M.Takahara,S.Sonoda,T.Tanaka,K.Baba,K.Yabuuchi,H.<Kurata,T.>___ー: "Human herpesvirus 6 infections in renal transplantation" Transplantation. 49. 519-522 (1990)

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      1990 Annual Research Report
  • [Publications] Kido,S.Kondo,K.Kondo,T.Morishima T.<Takahashi,M.>___ーYamanishi,K.: "Detection of human herpesvirus 6 DNA in throat swabs by polymerase chain reaction" J.Med.Virol.32. 139-142 (1990)

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      1990 Annual Research Report
  • [Publications] Kondo,K.Hayakawa,Y.Mori,H.Sato,S.Kondo,T.Takahashi,K.Minamishima,Y.<Takahashi,M.>___ーYamanishi,K.: "Detection by polymerase chain reaction amplification of human herpesvirus 6 DNA in peripheral blood of patients with exanthem subitum" J.Clin.Microbiol.28. 970-974 (1990)

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      1990 Annual Research Report
  • [Publications] Shiraki,K.Mukai,T.Okuno,T.Yamanishi,K.<Takahashi,M.>___ー: "Physicochemical characterization of human herpesvirus 6 infectivity" J.Gen.Vorol.(1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Kondo,K.Kondo,T.Okuno,T.<Takahashi,M.>___ーYamanishi,K.: "Latant infection of human herpesvirus 6(HHVー6)in human monocyte/macrophages" J.Gen.Virol.(1991)

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      1990 Annual Research Report
  • [Publications] Kido,S.Ozaki,T.Asada,H.Higashi,K.Kondo,K.Hayakawa,Y.Morishima,T.<Takahashi,M.>___ーYamanishi,K.: "Detection of varicellaーzoster virus(VZV)DNA in clinical samples from patients with VZV by the polymerase chain reaction" J.Clin.Microbiol.29. 76-79 (1990)

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      1990 Annual Research Report
  • [Publications] <Takahashi,M.>___ーBaba,K.Horiuchi,K.Kamiya,H.Asano,Y.: "A live varicella vaccine" <in>___ー Immunobiology and Prophylaxis of Human herpesvirus Infections. 49-58 (1990)

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      1990 Annual Research Report
  • [Publications] Ibusuki,K.<Minamishima,Y.>___ー: "Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections" Nat.Immun.Cell Growth Regul.9. 121-128 (1990)

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  • [Publications] Kumura,K.Ibusuki,K.<Minamishima,Y.>___ー: "Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus" Virology. 175. 572-574 (1990)

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  • [Publications] XuーBin: "β_2 microglobulin Receptor is Located on a Major Human Cytomegalovirus Protein 65 kDa Sharing the Site of IgG Fc Receptor." J.Kanazawa Med.Univ.15. 142-148 (1990)

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      1990 Annual Research Report
  • [Publications] 村山 次哉、<古川 宣>___ー、地崎 赴美子、館野 恵美子、平井 莞二、: "PCR法のサイトメガロウイルス診断への応用" 臨床とウイルス. 18. 345-348 (1990)

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  • [Publications] <古川 宣>___ー: "サイトメガロウイルスワクチン" 日本臨床. 48. 743-748 (1990)

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  • [Publications] Lopez,C.<Mori,R.>___ーRoizman,B.Whitley,R.J.,Edt.: "Immunobiology and Prophylaxis of Human Herpesvirus Infections" Plenum Pless,New York and London, 296 (1990)

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  • [Publications] Kino,Y.: "Immunogenicity of herpes simplex virus glycoprotein gB-1-related protein produced in yeast" Viccine. 7. 155-160 (1989)

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      1989 Annual Research Report
  • [Publications] Hatano,A.: "Pathogenicity of herpes simplex virus type 1 in mice after thr intranasal route of inoculation." Proseedings of XIV World Congress of Otorhinolaryngology Head & Neck Surgery.

    • Related Report
      1989 Annual Research Report
  • [Publications] Kumura,K.: "Independent existence of mutations responsible for temperature sensitivity and attenuation in a mutant of murine cytomegalovirus." Virology. (1990)

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      1989 Annual Research Report
  • [Publications] Ibusuki,K.: "Effect of Chlorella vulgaris extracts on murine cytomegalovirus infections." Nat.Immun.Cell Growth Regul.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Linhares,M.I.S.: "Prevalence of cytomegalovirus avtibodies in Brazillian and Japanese populations in the North-east of Brazill." Microbiol.Immunol.33. 975-980 (1989)

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      1989 Annual Research Report
  • [Publications] Linhares,M.I.S.: "Prevalence of cytomegalovirus antibodies in Brazillian women of childbearing age and newborns." Acta Paediatr.Jpn.31. 620-622 (1989)

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      1989 Annual Research Report
  • [Publications] Fizuru,Y.: "Immunological and molecular comparison of simian cytomegalo-viruses isolated from African green monkey(Cercopithecus aethiops)and Japanese macaque(Macaca fuscata)." Arch.Virol.107. 65-75 (1989)

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      1989 Annual Research Report
  • [Publications] Ohashi,T.: "Induction of resistance in mice against murine cytomegalovirus by cellular components of Lactobacillus casei." Biotherapy. 1. 89-95 (1989)

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      1989 Annual Research Report
  • [Publications] Shimizu,Y.: "Immunological studies of Sjoqrne's syndrome.No.3 Anti cytomegalovirus neutralizing antibody in the sera." J.Jpn.Stomal.Soc.38. 82-87 (1989)

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      1989 Annual Research Report
  • [Publications] Shimizu,Y.: "Virological study of recurrent intraoral herpes simplex virus infection." J.Jpn.Stomal.Soc.38. 198-205 (1989)

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      1989 Annual Research Report
  • [Publications] Shimokawa,K.: "Comparative study with monospecific and monoclonal antibodies against a 65K human cytomegalovirus protein" Arch.Virol.101. 79-86 (1988)

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      1989 Annual Research Report
  • [Publications] Xu-Bin,T.: "Characterization of IgG Fc receptors induced by human Cytomegalovirus." J.Gen.Virol.70. 893-900 (1989)

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      1989 Annual Research Report
  • [Publications] Murayama,T.: "Biological response modifier enhances the activity of natural killer cell against human cytomegalovirus-infected cells." J.Med.Virol.29. 102-108 (1989)

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      1989 Annual Research Report
  • [Publications] Takahashi,K.: "Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus" J.Virol.63. 3161-3163 (1989)

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      1989 Annual Research Report
  • [Publications] Kondo,K.: "Detection of Human Herpesvirus 6(HHV-6)DNA in peripheral blood of exanthema subitum patients by polymerase chain reaction DNA amplification" J.Clin.Microbiol.(1990)

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      1989 Annual Research Report
  • [Publications] Sakuma,S.: Archives of Virology. 101. 169-182 (1988)

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      1988 Annual Research Report
  • [Publications] Minagawa,H.: Archives of Virology. 103. 73-82 (1988)

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      1988 Annual Research Report
  • [Publications] Yamada,M.: Archives of Virology. 99. 101-109 (1988)

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      1988 Annual Research Report
  • [Publications] Nakamura,S.: Yonago Acta medica. (1989)

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      1988 Annual Research Report
  • [Publications] Takahashi,K.: Journal of Virology. (1989)

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      1988 Annual Research Report
  • [Publications] Okuno,T.: Transplantation. (1989)

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      1988 Annual Research Report
  • [Publications] Eizuru,Y.: Journal of Clinical Microbiology. 26. 1881-1883 (1988)

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      1988 Annual Research Report
  • [Publications] Nakamura,k.: Microbiology and Immunology. 32. 925-931 (1988)

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      1988 Annual Research Report
  • [Publications] Sakihama,K.: Microbiology and Immunology. 32. 933-947 (1988)

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      1988 Annual Research Report
  • [Publications] Ohashi,T.: Archives of Virology. 101. 237-247 (1988)

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      1988 Annual Research Report
  • [Publications] Ohashi,T.: Biotherapy. 1. 27-39 (1988)

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      1988 Annual Research Report
  • [Publications] Eizuru,Y.: Intervirology. 29. 339-345 (1988)

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      1988 Annual Research Report
  • [Publications] Eizuru,Y.: Acta Pediatrica Japonica. 30. 703-709 (1988)

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      1988 Annual Research Report
  • [Publications] Nakamura,K.: Journal of Medical Virology. 26. 363-373 (1988)

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      1988 Annual Research Report
  • [Publications] Eizuru,Y.: The Lancet. i. 40-40 (1989)

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      1988 Annual Research Report
  • [Publications] Shimokawa,K.: Archives of Virology. 101. 79-86 (1988)

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      1988 Annual Research Report
  • [Publications] Xu Bin.: Journal of General Virology. (1989)

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      1988 Annual Research Report

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Published: 1988-03-31   Modified: 2016-04-21  

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