| Project/Area Number |
63304038
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | University of Tokyo |
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Principal Investigator |
WADA Osamu University of Tokyo, Department of Hygiene and Preventive Medicine, Professor, 医学部・医学科, 教授 (60009933)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMURA Yukio St. Marianna University School of Medicine, Department of Public Health, Profess, 教授 (40081658)
MANABE Shigeo University of Tokyo, Department of Hygiene and Preventive Medicine, Assistant pr, 医学部・医学科, 助教授 (90165928)
HORIGUCHI Shunichi Osaka City University Medical School, Department of Preventive Medicine and Envi, 医学部, 教授 (60046828)
SHIMA Shogo FuJita Health University School of Medicine, Department of Public Health, Profes, 医学部, 教授 (40084511)
ISHINISHI Noburu Kyushu University, Department of Hygiene, Professor, 医学部, 教授 (80037340)
松本 信雄 東京慈恵会医科大学, 衛生学, 教授 (30009998)
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥16,600,000 (Direct Cost: ¥16,600,000)
Fiscal Year 1990: ¥4,000,000 (Direct Cost: ¥4,000,000)
Fiscal Year 1989: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1988: ¥7,500,000 (Direct Cost: ¥7,500,000)
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| Keywords | Semiconductor metals / Tumorigenicity / Immuno-toxicity / Mutagenicity / Embryonic toxicity / Arsenicals / Indium / Germanium / 先端産業 / 金属毒性 / ガリウム砒素 / トリエチルアルシン / アンチモン / トリメチルアルシン / ガリウム / 新素材金属 / ニッケル / インジウム |
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| Research Abstract |
Eco-bio-toxicological investigations on newly developed metal compounds as the semiconductor materials or biomaterials were carried out to obtain basic toxicological data.
(1) Tumorigenicity : Intratracheal injection of InAs and InP particles produced severe lung damage, but they showed no apparent tumorigenicity. Intraperitoneal injections of GaAs and GaP, and implantation of nickel alloy in thigh muscle of mice showed a significant tumorigenicity.
(2) Immunotoxicity : Number of polyclonal IgG production cells in spleens of mice treated with Be, Pt and Ni was increased, but that with Zr and Co showed no change. Be, Pt, and Ni seem to have the immunological cytotoxicity as antigenicity.
(3) Embryonic toxicity : Ni showed a strong effect on the embryonic growth at the stage of organogenesis.
(4) Mutagenicity : Be, Ga, Sb and As showed a DNA damaging activity in rec-assay, but no mutagenicity to Salmonella in Ames test. In SCE test using V79 cells, Sb, Be and As induced SCE.
(5) Metabolic study, general toxicity : Germanium and trimethylarsine are rapidly excreted in urine. In rats with renal lesion, the retention of these chemicals in the body was increased as compared with normal rats. General toxicity of As is in the order of arsine > triethylarsine > trimethylarsine. Sb affects the osmotic fragility of red blood cell membrane. Indium selectively affects renal tubules in low concentrations. These findings offer a basic toxicological data of these new metals.
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