| Project/Area Number |
63304061
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
放射線5生物学
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
YOKORO Kenjiro Hiroshima Univ., Res. Inst. Nucl. Med. Biol., Professor, 原爆放射能医学研究所, 教授 (70034618)
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| Co-Investigator(Kenkyū-buntansha) |
SAWADA Shozo Hiroshima Univ., Res. Inst. Nucl. Med. Biol., Professor, 原爆放射能医学研究所, 教授 (60034625)
KAMADA Nanao Hiroshima Univ., Res. Inst. Nucl. Med. Biol., Professor, 原爆放射能医学研究所, 教授 (00034629)
SATOW Yukio Hiroshima Univ., Res. Inst. Nucl. Med. Biol., Professor, 原爆放射能医学研究所, 教授 (70034634)
YOSHIKAWA Isao Nagasaki Univ., Sch.of Med., Ass. Professor, 医学部, 助教授 (80039528)
NIKAIDO Osamu Kanazawa Univ., Pharmaceu., Professor, 薬学部, 教授 (60019669)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥18,400,000 (Direct Cost: ¥18,400,000)
Fiscal Year 1989: ¥8,400,000 (Direct Cost: ¥8,400,000)
Fiscal Year 1988: ¥10,000,000 (Direct Cost: ¥10,000,000)
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| Keywords | Risk assessment of neutrons in man / RBE of neutrons / Carcinogenesis in man and rodents / Biological effect of ^<252>Cf neutrons / 被曝者及び動物における発癌 / ^<252Cf>中性子の生物影響 |
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| Research Abstract |
The aim of this research group is to assess the contribution of fission neutrons including the somatic and genetic effects being observed among the atomic bomb survivors in Hiroshima and Nagasaki. In order to accomplish this, we have carried out experimental studies using both in vivo and in vitro systems, and have estimated the relative biological effectiveness (RBE) of neutrons for various biological aspects. The experimental equipments such as ^<252>Cf neutron source, the facility for tritiated water study and ^<137>Cs simulatoring apparatus which have been established at the Research Institute for Nuclear Medicine and Biology, Hiroshima University, have undoubtedly facilitated the work of this research group. Because of the availability of these equipment, we could obtain much more valuable data than anticipated although the assigned period of research was short, only for two years. Research subjects dealt with this group included carcinogenesis study in mice, induction of congenital malformations in mice irradiated in utero, cell killing, and induction of chromosomal aberrations and cell transformation in both human and rodents in vitro, DNA damage and its repair, induction of gene and chromosomal mutations in rodent and Drosophila, intervening effect of Fe in altering neutron energy and RBE, and so on. However, since there still are many aspects remain to be explored, such as comparative study of neutrons of different energy, biological effect of low dose region with low dose-rates, molecular aspect of radiation-induced carcinogenesis, and assessment of hormetic effect of low and high LET radiations, the continuity of the study should be indispensable to gain an insight into the mechanism of biological effects of neutrons.
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