| Project/Area Number |
63440049
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Fukuta Health University |
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Principal Investigator |
MATSUMOTO Sumio Fujita Health Univ., Dept of Surgery, Associate Professor, 医学部, 助教授 (80124957)
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| Co-Investigator(Kenkyū-buntansha) |
TAN Mitsuaki Fujita Health Univ., Assistant, 医学部, 助手 (80192186)
TSUKADA Norio Fujita Health Univ., Assistant, 医学部, 助手 (30201635)
KUTSUNA Tetsuji Fujita Health Univ., Researcher, 医学部, 研究員 (60175312)
水野 有朋 藤田学園保健衛生大学, 医学部, 助手 (50200019)
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥13,100,000 (Direct Cost: ¥13,100,000)
Fiscal Year 1990: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1989: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1988: ¥9,700,000 (Direct Cost: ¥9,700,000)
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| Keywords | Lymphokine activated killer / Interleukin-2 / Thoracic duct / Major histocompatibility complex / Beta 2 microgobulin / Adopted immunotherapy / 胸管リンパ球 / Lymphokine activated killer / beta_2 microglobulin / 免疫療法 / キラ-T細胞 |
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| Research Abstract |
In these several years, we applied LAK induced from thoracic duct lymphocytes to patients with recurrent malignant tumor. Nine patients were treated had LAK induced from thoracic duct lymphocytes and/or peripheral blood lymphocytes. Gastric, breast or pancreatic cancer did not show tumor regress. Three colorectal cancer did not show tumor growth during LAK treatment. One hepatoma case with hepatic, iliac bone and lung metastases showed complete tumor necrosis of hepatic metastasis, however, LAK was ineffective for the iliac bone and lung metastases. Immunohistochemical stain revealed that beta2 microgobulin (BMG) was positive on the cell surface of hepatic metastasis and negative in iliac bone and lung metastatic site. BMG was a small component of major histocompatibility complex class 1 antigen. Our results suggested a possibility that LAK might contain cytotoxic Tlympohcytes or induce them. Until now, we tried to make much more amount or more cytotoxic LAK, but now we investigate again about the antigen presentation on target cell surface and the relation about application and cytotoxic effect of LAK.
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