| Project/Area Number |
63440050
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Thoracic surgery
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| Research Institution | Faculty of Medicine, University of Tokyo |
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Principal Investigator |
IMACHI Kou Univ. of Tokyo, Medicine, Assoc. Prof., 医学部(医), 助教授 (10010076)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMASA Iwao Univ of Tokyo, RCAST, Prof, 先端科学技術研究センター, 教授 (30010028)
YONEZAWA Takumi Univ. of Tokyo, Medicine, Instructor, 医学部, 助手 (50221677)
CHINZEI Tsuneo Univ of Tokyo, RCAST, Instructor, 先端科学技術研究センター, 助手 (20197643)
MABUCHI Kunihiko Univ of Tokyo, RCAST, Assoc Prof, 先端科学技術研究センター, 助教授 (50192349)
ABE Yusuke Univ. of Tokyo, Medicine, Instrutor, 医学部, 助手 (90193010)
渥美 和彦 東京大学, 医学部, 教授 (70009877)
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| Project Period (FY) |
1988 – 1991
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| Project Status |
Completed (Fiscal Year 1991)
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| Budget Amount *help |
¥30,100,000 (Direct Cost: ¥30,100,000)
Fiscal Year 1991: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1990: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1989: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1988: ¥21,500,000 (Direct Cost: ¥21,500,000)
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| Keywords | Artificial heart / Jellyfish valve / Control of artificial heart / Pathophysiology in artificial heart / Atrial natriuretic peptide / Thrombus formation / Renal function / 血漿タンパク吸着 / 心臓血管中枢 / 末梢抵抗 / Jelly fish弁 / 心房利尿性ホルモン / 血行動態 / 人工弁 / 左心バイパス / 右心バイパス |
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| Research Abstract |
The objectives of this study are to clarify the mechanism of pathophysiological problems such as anemia, CVP elevation, low thyroid hormone, etc., generated during the total artificial heart pumping, and to establish an optimum control method of total artificial heart. The following results has been obtained in these 4 years.
1. To improve the antithrombogenicity of the blood pump, a new polymer membrane valve, jellyfish valve, was developed. By using this valve the antithrombogenicity of the blood pump was improved greatly and many pathophysiological problems were disappeared, which would give us a hint to clarify the mechanism of pathophysiological problems. The valve was attracted attention internationally, and the cooperative research has begun with many laboratories in USA and Europe.
2. We found that a strong nervous reflex occured in the goat when we cutoff an ascending aorta to connect a left outflow cannula, which had never been experienced when we connected the cannula to a des
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cending aorta.
3. Concerning the renal functions, we found that renal plasma flow, renal blood flow, and glomerular filtration rate showed significantly decreases after TAH implantation and that the cause of these phenomena would be due to a CVP elevation.
4. To seek the cause of CVP elevation, the influence of TAH on the dynamics of atrial natriuretic peptide (ANP) was studied. We found that although the secretion of ANP was not changed by TAH pumping, it did not increase when CVP increased, and that the natriuretic effect of ANP on the kidney was strongly suppressed in. TAH goats.
5. As for the control of artificial heart, total right heart bypass and separate circulation between upper and lower half body with an artificial heart were carried out to clarify the control mechanism of the circulatory system and natural heart. Utilizing the results obtained from these experiments, a new automatic control method in which the output of TAH was controlled with the changes in total peripheral resistance. This method could keep a TAH animal in a good condition including exercise state and keep CVP in normal range. Less
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