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Clarification of the pathophysiological mechanism associated with a total artificial heart (TAH) and establishment of optimum control method of TAH

Research Project

Project/Area Number 63440050
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field Thoracic surgery
Research InstitutionFaculty of Medicine, University of Tokyo

Principal Investigator

IMACHI Kou  Univ. of Tokyo, Medicine, Assoc. Prof., 医学部(医), 助教授 (10010076)

Co-Investigator(Kenkyū-buntansha) FUJIMASA Iwao  Univ of Tokyo, RCAST, Prof, 先端科学技術研究センター, 教授 (30010028)
YONEZAWA Takumi  Univ. of Tokyo, Medicine, Instructor, 医学部, 助手 (50221677)
CHINZEI Tsuneo  Univ of Tokyo, RCAST, Instructor, 先端科学技術研究センター, 助手 (20197643)
MABUCHI Kunihiko  Univ of Tokyo, RCAST, Assoc Prof, 先端科学技術研究センター, 助教授 (50192349)
ABE Yusuke  Univ. of Tokyo, Medicine, Instrutor, 医学部, 助手 (90193010)
渥美 和彦  東京大学, 医学部, 教授 (70009877)
Project Period (FY) 1988 – 1991
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥30,100,000 (Direct Cost: ¥30,100,000)
Fiscal Year 1991: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1990: ¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1989: ¥3,800,000 (Direct Cost: ¥3,800,000)
Fiscal Year 1988: ¥21,500,000 (Direct Cost: ¥21,500,000)
KeywordsArtificial heart / Jellyfish valve / Control of artificial heart / Pathophysiology in artificial heart / Atrial natriuretic peptide / Thrombus formation / Renal function / 血漿タンパク吸着 / 心臓血管中枢 / 末梢抵抗 / Jelly fish弁 / 心房利尿性ホルモン / 血行動態 / 人工弁 / 左心バイパス / 右心バイパス
Research Abstract

The objectives of this study are to clarify the mechanism of pathophysiological problems such as anemia, CVP elevation, low thyroid hormone, etc., generated during the total artificial heart pumping, and to establish an optimum control method of total artificial heart. The following results has been obtained in these 4 years.
1. To improve the antithrombogenicity of the blood pump, a new polymer membrane valve, jellyfish valve, was developed. By using this valve the antithrombogenicity of the blood pump was improved greatly and many pathophysiological problems were disappeared, which would give us a hint to clarify the mechanism of pathophysiological problems. The valve was attracted attention internationally, and the cooperative research has begun with many laboratories in USA and Europe.
2. We found that a strong nervous reflex occured in the goat when we cutoff an ascending aorta to connect a left outflow cannula, which had never been experienced when we connected the cannula to a des … More cending aorta.
3. Concerning the renal functions, we found that renal plasma flow, renal blood flow, and glomerular filtration rate showed significantly decreases after TAH implantation and that the cause of these phenomena would be due to a CVP elevation.
4. To seek the cause of CVP elevation, the influence of TAH on the dynamics of atrial natriuretic peptide (ANP) was studied. We found that although the secretion of ANP was not changed by TAH pumping, it did not increase when CVP increased, and that the natriuretic effect of ANP on the kidney was strongly suppressed in. TAH goats.
5. As for the control of artificial heart, total right heart bypass and separate circulation between upper and lower half body with an artificial heart were carried out to clarify the control mechanism of the circulatory system and natural heart. Utilizing the results obtained from these experiments, a new automatic control method in which the output of TAH was controlled with the changes in total peripheral resistance. This method could keep a TAH animal in a good condition including exercise state and keep CVP in normal range. Less

Report

(5 results)
  • 1991 Annual Research Report   Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (58 results)

All Other

All Publications (58 results)

  • [Publications] K.Imachi: "Design criteria of implantable blood pump in the goat's chest cavity" Artificial Heart 2. 726-728 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 井街 宏: "新しい発想による人工心臓ポンプ用弁(Jelly fish Valve)の設計開発" 人工臓器. 18. 637-640 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 井街 宏: "密着方式CCDによる微小循環のinーsitu観察" 医用電子と生体工学(特別号). 27. 318 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Imachi: "Is atrial natriuretic polypepatide a cause of pathophysiology in total artificial heart animal" Artificial heart 2. 463-465 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 阿部 裕輔: "人工心臓の制御のための生体制御機構の解明" 人工臓器. 18. 602-606 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鎮西 恒雄: "運動時の人工心臓拍出量の自動制御" 人工臓器. 18. 615-618 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Imachi: "In-Vitro and in-vivo evaluation of a jellyfish valve for practical use" Trans.Am.Soc.Artif.Organs. 35. 298-301 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Mabuchi: "Use of total right heart bypass model for analyses of abnormal hemodynamics in total artificial heart animals,and the function and regulatory mechanism of natural heart" Trans.Am.Soc.Artif.Intern.Organs. 35. 705-708 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y.Abe: "Separate circulation with an artificial heart for study of artificial heart control" Artificial Organs. 13. 283-283 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 阿部 裕輔: "人工心臓循環における末梢循環系の適応に関する研究" 医用電子と生体工学. 28. 192 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] T.Chinzei: "Automatic control of total artificial heart to simulate the hemodynamics under natural circulation" Artificial Oragns. 13. 292-292 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鎮西 恒雄: "人工心臓制御のための自然心臓動物および人工心臓動物における循環モデルの検討" 人工臓器. 19. 45-48 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 井街 宏: "完全人工心臓埋め込み手術と神経反射" 人工臓器. 19. 129-132 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 鎮西 恒雄: "人工心臓制御のための自然心臓動物および人工心臓動物における循環モデルの検討" 人工臓器. 19. 45-48 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 満渕 邦彦: "人工心臓血液ポンプ内面における吸着血漿タンパクの分布の解析" 人工臓器. 19. 1109-1113 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Mabuchi: "Renal function and renal response to extrinsic atrial natriuretic polypeptide intotal artificial heart animals" Procedings of Nihon Univ.Intrncctional Symposium on the development of Biomaation in 21st century-Artificial heart.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 野沢 広彰: "完全人工心臓装着による腎機能変化の検討" 人工臓器. 20. 1347-1356 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Imachi: "Blood compatibility of the jellyfish valve without anticoagulant." ASAIO Transactions. 37. 220-222 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Mabuchi et al.: "Suppression of the natriuretic peptide in animals with total artificial heart" ASAIO Transaction. 37. 214-216 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y.Abe et al.: "Separate circulation with an artificial heart for the study of artificial heart control." Artificial Organs. 14. 76-78 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 井街 宏: "人工心臓用Jellyfish弁の試作と性能評価" 人工臓器. 20. 789-794 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 今西 薫: "心臓移植の手術手技で装着可能な人工心臓ポンプの開発" 人工臓器. 20. 699-704 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 野沢 宏彰: "完全人工心臓装着による腎機能変化の検討" 人工臓器. 20. 1347-1356 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] 阿部 裕輔: "完全置換型人工心臓の循環系パラメ-タを介するフィ-ドバック自動制御" 医用電子と生体工学.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Imachi: "A newly designed jellyfish valve for an artificial heart blood pump" Trans Am Soc Artif Intern Organs. 34. 726-728 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Maeda: "Predictive control by physical activity rate of a total artificial heart during exercise" Trans Am Soc Artif Intern Organs. 34. 480-484 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Mabuchi: "Is atrial natriuretic polypeptide a cause of pathophysiology in total artificial heart" Trans Am Soc Artif Intern Organs. 34. 463-465 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Imachi: "Predictive control of total artificial heart during exercise" Proceedings of ESAO', 88 Satellite Symposium on Total Artificial Heart-Problems of Regulation. 101-105 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Imachi: "In-vitro and in-vivo evaluation of a jellyfish valve for practical use" Trans Am Soc Artif Intern Organs. 35. 298-301 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Mabuchi: "Use of total right heart bypass model for analysis of abnormal hemodynamics in TAH animals, and regulatory mechanism of a natural heart" Trans Am Soc Artif Intern Organs. 35. 705-708 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Atsumi: "Research and development of artificial heart in Japan" J Biomaterials Application. 4. 162-224

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Imachi: "Blood compatibility of the jellyfish valve without anticoagulant" ASITO Transaction. 37. 220-222 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K. Mabuchi: "Suppression of natriuretic peptide in animals with TAH" ASAIO Transaction. 37. 214-216 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Y. Abe: "Separate circulation of with an artificial heart control" Artificial Organs. 14(Suppl). 76-78 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] K.Mabuchi et al.: "Suppression of the natriuretic peptide in animals with total artificial heart" ASATO Transaction. 37. 214-216 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] Y.Abe et al.: "Separate circulation with an artificial heart for the study of artificial heart control." Artificial Organs. 14. 76-78 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 井街 宏: "人工心臓用Jell fish弁の試作と性能評価" 人工臓器. 20. 789-794 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 今西 薫: "心臓移植の手術手技で装着可能な人工心臓ポンプの開発" 人工臓器. 20. 699-704 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 野沢 宏彰: "完全人工心臓装着による腎機能変化の検討" 人工臓器. 20. 1347-1356 (1991)

    • Related Report
      1991 Annual Research Report
  • [Publications] 阿部 裕輔: "完全置換型人工心臓の循環系パラメ-タを介するフィ-ドバック自動制御" 医用電子と生体工学.

    • Related Report
      1991 Annual Research Report
  • [Publications] 井街 宏: "完全人工心臓埋め込み手術と神経反射" 人工臓器. 19. 129-132 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鎮西 恒雄: "人工心臓制御のための自然心臓動物および人工心臓動物における循環モデルの検討" 人工臓器. 19. 45-48 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Imachi: "The development of a Jellyfish valve for TAH and improvement of pathophysiological abnormalities in TAH animals" Proceedings of 2nd Artificial Heart Symposium.

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Mabuchi: "Renal function and renal response to extrinsic atrial natriuretic polypeptide intotal artificial heart animals" Proceedings of Nihon Univ.International Symposium on the development of Biomation in 21st centuryーArtificial heart.

    • Related Report
      1990 Annual Research Report
  • [Publications] 野沢 宏彰: "完全人工心臓装着による腎機能変化の検討" 人工臓器. 20. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 阿部 裕輔: "上下分離人工心臓循環における心拍数比例制御下の循環動態に関する研究" 人工臓器. 20. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Imachi: "In-Vitro and in-vivo evaluation of a jellyfish valve for practical use" Trans.Am.Soc.Artif.Tntern.Organs. 35. 298-301 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Mabuchi: "Use of total right heart bypass model for analyses of abnormal hemodynamics in total artificial heart animals,and the function and regulatory mechanism of natural heart" Trans.Am.Soc.Artif.Intern.Organs. 35. 705-708 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Abe: "Separate circulation with an artificial heart for study of artificial heart control" Artificial Organs. 13. 283-283 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 阿部裕輔: "人工心臓循環における末梢循環系の適応に関する研究" 医用電子と生体工学. 28. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Chinzei: "Automatic control of total artificial heart to simulate the hemodynamics under natural circulation" Artificial Organs. 13. 292-292 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 鎮西恒雄: "人工心臓制御のための自然心臓動物および人工心臓動物における循環モデルの検討" 人工臓器. 19. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Imachi: Artificial Heart 2. 726-728 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 井街宏: 人工臓器. 18. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 井街宏: 医用電子と生体工学(特別号). 27. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Imachi: Artificial heart2. 463-465 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 阿部裕輔: 人工臓器. 18. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 鎮西恒雄: 人工臓器. 18. (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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