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Inhomogeneous Distribution of Pulmonary Gas Transport Caused by Mechanical Ventilation and Asymmetric Lung Pathophysiologies.

Research Project

Project/Area Number 63440057
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 麻酔学
Research InstitutionUniversity of Tokyo

Principal Investigator

NUMATA Katsuo  Dept. of Otolaryngclogy, University of Tokyo, Professor., 医学部・附属病院, 教授 (40048947)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Kouki  Dept. of Otolaryngology, University of Tokyo. Assistant Professor, 医学部附属病院, 講師 (40114714)
SAWAMURA Shigehito  Dept. of Otolaryngology, University of Tokyo. Assistant, 医学部附属病院, 助手
SUZUKAWA Masayuki  Dept. of Otolaryngology, University of Tokyo, Assistant Professor, 医学部附属病院, 講師 (00162917)
YAMADA Yoshitsugu  Dept. of Otolaryngology, University of Tokyo, Assistant, 医学部附属病院, 助手 (30166748)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥19,800,000 (Direct Cost: ¥19,800,000)
Fiscal Year 1990: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥5,100,000 (Direct Cost: ¥5,100,000)
Fiscal Year 1988: ¥12,600,000 (Direct Cost: ¥12,600,000)
Keywordsinhomogeneous lung pathophysiology / distribution of pulmonary gas transport / high frequency ventilation / constant flow ventilation / asymmetric airway constriction / asymmetric lung lavage / augmented dispersion / 力学的様互作用 / 片側性気道狭窄 / 片側性ラバ-ジュ / 肺ガス運搬 / 肺胸郭系インピーダンススペクトル / 気道内動圧 / オレイン酸肺傷害 / pulsatile sustained inflarion / 局所死腟不均等分布 / 肺ガス運搬数学モデル
Research Abstract

The effects of various modes of mechanical ventilation on the distribution of pulmonary gas transport were assessed from the washout of nitrogen-13 by positron emission tomography. During conventional ventilation at 10 /min, vertical gradients of regional ventilation were observed in all levels of transverse sections with dependent regions more ventilated than nondependent regions. During high-frequency ventilation (HFV) over 3 Hz, a central region at the base of the lungs was highly ventilated, with peripheral regions less ventilaed. This characteristic pattern in HFV strongly supports the hypothesis that direct convection of fresh gas is an important mechanism of gas transport. Constant flow ventilation (CFV) had a very inhomogenous distribution of gas transport with a preferential ventilation to dorsal lung regions. This distribution was caused by deeper energy penetration into the bronchial tree in the direction of jet stream, while cardiogenic oscillation facilitated gas transport mainly in pericardial regions. We also developed the experimental system in which the distributions of ventilatory flow (VT) and gas transport (VA) could be simultaneously measured in asymmetric lung disease models (predominantly increased resistance or decreased compliance, respectively). This system proved that inhomogeneous lung pathophysiologies mechanically interact with the ventilatory settings and alter the distribution of VT differently in various ventilatory modes. In spite of inhomogeneous distribution of VT, the distribution of VA became homogeneous with f in high f range, suggesting that dispersive gas transport mechanism was increasingly important with f in HFV.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (30 results)

All Other

All Publications (30 results)

  • [Publications] Y.Yamada,C.Burnham,C.A.Hales,J.G.Venegas: "Regional mapping of gas transport during highーfrequency and conventional ventilation." J.Appl.Physiol.66. 1209-1218 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] J.G.Venegas,Y.Yamada,J.Custer,C.A.HaIes: "Effects of respiratory variables on regional gas transport during highーfrequency ventilation." J.Appl.Physiol.64. 2108-2118 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] J.G.venegas,Y.Yamada,C.Burnham,C.A.Hales: "Local gas transport in eucapnic ventilation:effectS of gravity and breathing frequency." J.Appl.Physiol.68. 2287-2295 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K.Suzuki,Yamada,S.Sawamura,K.Numata: "Effects of ventilatory modes and variables on regional ventilation in various asymmetric lung abnormalities." J.Appl.physiol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 山田 芳嗣: "CFV(定常流換気)のガス交換メカニズムと並列不均等" 呼吸と循環. 38. 329-336 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 山田 芳嗣: "人工呼吸の不均等換気分布" 病態生理. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 山田 芳嗣,諏訪 邦夫: "高頻度換気法ー基礎理論と臨床応用 In:Annual Review呼吸器1988" 中外医学社., 248-261 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Yamada, C. Burnham, C. A. Hales, and J. G. Venegas: "Regional mapping of gas transport during high-frequency and conventional ventilation." J. Appl. Physiol. 66(3). 1209-1218 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] J. G. Venegas, Y. Yamada, J. Custer, and C. A. Hales: "Effects of respiratory variables on regional gas transport during high-frequency ventilation." J. Appl. Physiol. 64(5). 2108-2118 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] J. G. Venegas, Y. Yamada, C. Burnham, and C. A. Hales: "Local gas transport in eucapnic ventilation : effects of gravity and breathing frequency." J. Appl. Physiol. 68(6). 2287-2295 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] K. Suzuki, Y. Yamada, S. Sawamura, T. Chinzei, K, Numata: "Effects of ventilatory modes and variables on regional ventilation in various asymmetric lung abnormalities." J. Appl. Physiol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] S. Sawamura, Y. Yamada, M, Suzukawa, T. Chinzei, K. Numata: "Efficacy of high frequency oscillation in oleic acid-induced severe lung injury." Anesthesiology. 71(3A). A1192 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Venegas JG, Yamada Y, Hales CA: "Local contributions of diffusion, jet flow and cardiac motion on transport resistance (R) in constant flow ventilation (CFV)." Federation Proc.48. A688 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] J.G.Venegas,Y.Yamada,C.Burnham,C.A.Hales: "Local gas transport in eucapnic ventilation:effects of gravity and breathing frequency." J.Appl.Physiol.68. 2287-2295 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山田 芳嗣: "CFV(定常流換気)のガス交換メカニズムと並列不均等" 呼吸と循環. 38. 329-336 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山田 芳嗣: "人工呼吸の不均等換気分布" 病態生理. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] K.Suzuki,Y.Yamada,S.Sawamura,K.Numata: "Effects of ventilatory modes and variables on regional ventilation in various asymmetric lung abnormalities." J.Appl.Physiol.

    • Related Report
      1990 Annual Research Report
  • [Publications] 沢村 成史,鈴木 郷子,繁田 正毅,山田 芳嗣他: "重症オレイン酸肺障害に対するHFOの有効性" 麻酔. 39. S367 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 鈴木 郷子,山田 芳嗣,沢村 成史,沼田 克雄: "不均等肺病変と人工呼吸の換気・ガス運搬分布" 麻酔. 40. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sawamura S,Yamada Y,et al: "Effieacy of highーfrequency oscillation in oleic acidーinduced severe lung injury" Anesthesiology. 71. A1192 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Venegas JG,Yamada Y,et al: "Local gas transport in eucapnie ventilation:effects of gravity and breathing frequency" J.Appl.Physiol. 68. inpress (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 山田芳嗣: "Constant flow ventilation" 呼吸. 8. 935-941 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 山田芳嗣: "定常流換気法のガス交換メカニズムと並列不均等" 呼吸と循環. 38. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] J.G.Venegas: J.Appl.Physiol.64. 2108-2118 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 山田芳嗣: 看護技術. 35. 58-61 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 山田芳嗣: 麻酔. 37. S177 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 沢村成史: 麻酔. 38. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 山田芳嗣: 麻酔. 38. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 山田芳嗣: 呼吸. 8.

    • Related Report
      1988 Annual Research Report
  • [Publications] 山田芳嗣: "Annual Review呼吸器1988 高頻度換気法ー基礎理論と臨床応用" 中外医学社, 248-261 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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