| Project/Area Number |
63440062
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Gunma University |
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Principal Investigator |
IGARASHI Masao Gunma University, School of Medicine Department of Obstetrics and Gynecology Professor, 医学部, 教授 (90008219)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAI Shunsaku Gunma University, School of Medicine Department of Neurology Professor, 医学部, 教授 (50010153)
MIZUNUMA Hideki Gunma University, School of Medicine Department of Obstetrics and Gynecology Ass, 医学部, 講師 (10125875)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥7,900,000 (Direct Cost: ¥7,900,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1988: ¥7,000,000 (Direct Cost: ¥7,000,000)
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| Keywords | osteoporosis / MD method / QDR-1000 / early detection / Estrogen therapy / physiological loss of bone mineral content / QDRー1000 / 老人 / 骨塩量 / BMD / Microdensitometry / エストロゲン / ビタミンD |
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| Research Abstract |
In order to establish the early detection and prevention methods of postmenopausal osteoporosis, spinal and femoral bone mineral contents were measured in Japanese women before and after menopause by dual energy X-ray absorptiometry-(QDR-1000, Hologic), and the following results were obtained. (1)The loss of bone mineral content was most rapid within 5 years after the menopause. This rapid decrease was interrupted for 10-20 years after menopause and resumed afterwards. (2)Serum osteocalcin, a major noncollagenous bone protein, showed significant elevation for 5 years after the menopause, and supported the rapid bone loss demonstrated during this period. (3)The microdensitometry method (MD method) for detection of osteoporosis had a weak correlation with spinal bone mineral content measured by QDR-1000, but each parameter such as GSmin, Sigma GS/D and MCI showed high correlation. In addition, HI-index ( Hi-index = MCI x GSmin x 100 ) had also high correlation, with bone mineral content, suggesting this index would be useful for the first screening method of osteoporosis. (4)Estrogen (Premarin) and vitamin D3 are effective on prevention of postmenopausal osteoporosis in Japanese women.
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