| Project/Area Number |
63460218
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
NAGAI T. Hoshi Univ., Professor, 薬学部, 教授 (40061270)
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| Co-Investigator(Kenkyū-buntansha) |
OHNISHI H. Hoshi Univ., Res. Associated, 薬学部, 助手 (00160565)
TAKAYAMA K. Hoshi Univ., Res. Associated, 薬学部, 助手 (00130758)
UEDA H. Hoshi Univ., Assistant Prof., 薬学部, 講師 (20061301)
MACHIDA Y. Hoshi Univ., Associat Prof., 薬学部, 助教授 (00061292)
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1990: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1989: ¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1988: ¥3,800,000 (Direct Cost: ¥3,800,000)
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| Keywords | Nasal absorption / Mucosa absorption / Interferon / Insulin / Liposome / Powder Dosage Form / Sodium Glycocholate / Permeability / グリココ-ル酸ナトリウム / インターフェロン / リポソーム / 表面電荷 / 粘膜付着 |
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| Research Abstract |
The nasal bioavailability of interferon in two different powder dosage forms, i. e. mixed powder (MP) and freeze-dried powder (FP) dosage forms was examined. It was confirmed that the titers of sample MP and sample FP after preparation were different, while their bioavailabilities in the nasal absorption study were not significantly different. In an attempt to clarify the above result, studies of stability and rabbit nasal absorption of interferon were performed. As a result, in the case sample MP, rapid inactivation seemed to take place mainly on the nasal mucosal membrane during the absorption stage. Therefore, we attempted to use liposome as a transmucosal therapeutic system, which has many advantages, for example, protection of the drug from degradation by peptidase on the mucosa, maintenance of a high concentration at the site of administration and facilitaion of their absorption from the mucosa. We have investigated the influence of permeability of liposome with entrapped insulin to determine the extent to which liposomes promote the permeation of insulin through the nasal mucosa, and to find whether liposomes themselves pass through the nasal mucosa.
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