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Syntheses of Metal Complexes for Diagnosis and Imaging of Tumor Tissue

Research Project

Project/Area Number 63470071
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 有機工業化学
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

OGOSHI Hisanobu  Kyoto Univ, Synthetic Chemistry, Professor, 工学部, 教授 (90026188)

Co-Investigator(Kenkyū-buntansha) SUZUKI Akihiro  Nagaoka National College of Technology, Research Associate, 合成化学, 助手 (60179190)
戸井 啓夫  長岡技術科学大学, 工学部, 助手 (90126475)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥6,700,000 (Direct Cost: ¥6,700,000)
Fiscal Year 1989: ¥1,800,000 (Direct Cost: ¥1,800,000)
Fiscal Year 1988: ¥4,900,000 (Direct Cost: ¥4,900,000)
KeywordsDiagnosis of Tumor / Imaging Prove / Metal Complex Accumulated in Tumor / Metalloporphyrin / ^<19>F-nmr / 画像化プロ-ブ / 画像化プローブ
Research Abstract

Selective accumulation of water-soluble porphyrin derivatives to tumor or cancer tissue have provided tool for diagnosis and therapy of earlier cancer with aid of photochemical method. However, application of this method is limited to diagnosis of superfacial tumor. Therefore, more elablrate chemical proves are required to detect the position of deep tumor from tissue surface and to make its three dimensional imaging. The first approach is incorporation of radioactive element in chemical prove selectively bound to the tumor tissue. Iodination of deuteroporphyrin was carried our by UV-irradiation of the mixture of porphyrin and iodine.
Present method is available to prepare particular porphyrin by using iodine highly diluted with radiocative one. Both fluorescence and photographic measurements can be applied to detect tumor in the deep place of tissues.
The second chemical prove is use of fluorinated dyes which are not found in mammalian tissues. ^<19>F-NMR spectra of the fluorinated proves in tissues are observable in high sensitivity. Isotropic shifts of ^<19>F-resonance are also measurable for the paramagnetic metal complexes of perfluoroalkyl- substituted porphyrins. Water soluble fluorinated porphyrins and their metal complexes are readily obtained by new synthetic method. Fluorinated dyes and their metal complexes are readily obtained by new synthetic method. Fluorinated dyes and complexes enable us to detect of tumor location and to define its size by photochemical method, electron spin resonance, and NMR spectroscopy.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] A.Suzuki,K.Okuda,Y.Kamiyama,H.Toi,Y.Aoyama and H.Ogoshi: "Preparation and Properties of Reconstituted Myoglobins with Chemically Modified Hemes." Nippon Kagaku Kaishi.No.4. 505-511 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Ozaki,K.Iriyama,H.Ogoshi and T.Kitagawa: "Characterization of Metalloporphyrins and Metallochlorins;Resonance Raman Studies." Nippon Kagaku Kaishi.No.4. 550-557 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Aoyama,A.Yamagishi,M.Asagawa,H.Toi and H.Ogoshi: "Molecular Recognition of Amino Acids:Two-Point Fixation of Amino Acids with Bifunctional Metalloporphyrins." J.Am.Chem.Soc.101. 4076-4077 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y.Aoyama,Y.Nonaka,Y.Tanaka,H.Toi and H.Ogoshi: "Poler Host-Guest Interactions. Solubilizing of Some Polar Compounds with Lipophilic Calix(6)arenes Containing Polar Group in Apolar Media." J.Chem.Soc.,Perkin Trans II.1025-1029 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H.Ogoshi,H.Hatakeyama,K.Yamamura and Y.Kuroda: "Novel 1:1 Complex of Rhodium(III)Porphyrins with Nucleobases." Chemistry Letters.51-54 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K.Aoyagi,H.Toi,Y.Aoyama and H.Ogoshi: "Facile Syntheses of Perfluoroalkylporphyrins Electron Deficient Porphyrin II." Chemistry Letters.29. 1891-1894 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A. Suzuki, K. Okuda, Y. Kamiyama, H. Toi, Y. Aoyama, and H. Ogoshi: "Preparation and Properties of Reconstituted Myoglobins with Chemically Modified Hemes." Nippon Kagaku Kaishi, No.4, 505-511, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Ozaki, K. Iriyama, H. Ogoshi and T. Kitagawa: "Characterization of Metalloporphyrins and Metallochlorins; Resonance Raman Studies." Nippon Kagaku Kaishi, No.4, 550-557, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Aoyama, A. Yamagishi, NM. Asagawa, H. Toi and H. Ogoshi: "Molecular Recognition of Amino Acids: Two-Point Fixation of Amino Acids with Bifunctional Metalloporphyrins." J. Am. Chem. Soc, 101, 4076-4077, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Y. Aoyama, Y. Nonaka, Y. Tanaka, H. Toi, and H. Ogoshi: "Polar Host-Guest Interaction. Solubilizing of Some Polar Compounds with Liphphilic Calix(6)arenes Containing Polar Group in Apolar Media." J. Chem. Soc., Perkin Trans II, 1025-1029, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Ogoshi, H. Hatakeyama, K. Yamamura and Y. Kuroda: "Novel 1:1 Complex of Rhodium(III) Porphyrins with Nucleobases." Chemistry Letters, 51-54, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] K. Aoyagi, H. Toi, Y. Aoyama and H. Ogoshi: "Facile Syntheses of Perfluoroalkylporphyrin Electron Deficient Porphyrin II." Chemistry Letters, 29, 1891-1894.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] A.Susuki,K.Okuda,K.Kamiyama,H.Toi,Y.Aoyama and H.Ogoshi: "Preparation and Properties of Reconstituted Myoglobins with Chemically Modified Hemes." Nippon Kagaku Kaishi.No4. 505-511 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Ozaki,K.Iriyama,H.Ogoshi and T.Kitagawa: "Characterization of Metalloporphyrins and Metallochlorins;Resonance Raman Studies." Nippon Kagaku Kaishi.No4. 550-557 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Aoyama,A.Yamagishi,M.Asagawa,H.Toi and H.Ogoshi: "Molecular Recognition of Amino Acids:Two-Point Fixation of Amino Acids with Bifunctional Metalloporphyrins." J.Am.Chem.Soc.101. 4076-4077 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Y.Aoyama,Y.Nonaka,T.Tanaka,H.Toi and H.Ogoshi: "Poler Host-Guest Interactions.Solubilizing of Some Polar Compounds with Lipophilic Calix(6)arenes Containing Polar Group in Apolar Media." J.Chem.Soc.,Perkin Trans II.1025-1029 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] H.Ogoshi,H.Hatakeyama,K.Yamamura and Y.Kuroda: "Novel 1:1 Complex of Rhodium(III)Porphyrins with Nucleobases." Chemistry Letters.51-54 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] K.Aoyagi,H.Toi,Y.Aoyama and H.Ogoshi: "Facile Syntheses of Perfluoroalkyporphyrins Electron Deficient Porphyrin II." Chemistry Letters.29. 1891-1894 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] A.Suzuki;K.Okuda; Y.Kamiyama,H.Toi;Y.Aoyama;H.Ogoshi: Nippon Kagaku Kaishi.4. 505-511 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Ozaki;K.Iriyama;H.Ogosh;T.Kitagawa: Nippon Kagaku Kaishi.4. 550-557 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Aoyama;A.Yamagishi;M.Asagawa;H.Toi;H.Ogoshi: J.Am.Chem.Soc.101. 4076-4077 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.Sakurai;H.Uchikubo;K.Ishidzu;K.Tajima;Y.Aoyama;H.Ogoshi: Inorganic Chem.27. 2691-2695 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Y.Aoyama;T.Uzawa;K.Saita;Y.Tanaka;H.Toi;H.Ogoshi: Tetrahedron Letters.29,41. 5271-5274 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Aoyagi;H.Toi;Y.Aoyama;H.Ogoshi: Chem.Lett.29. 1891-1894 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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