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Male-driven Molecular Evolution

Research Project

Project/Area Number 63480003
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 遺伝学
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MIYATA Takashi  Kyushu Univ. Fac. of Sci. Associate Prof., 理学部, 助教授 (20022692)

Co-Investigator(Kenkyū-buntansha) MIZUNO Shigeki  Tohoku Univ. Fac. of Agr. Professor, 農学部, 教授 (90112903)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥6,900,000 (Direct Cost: ¥6,900,000)
Fiscal Year 1989: ¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1988: ¥4,200,000 (Direct Cost: ¥4,200,000)
KeywordsMutation rate / DNA replication / Error / Autosome / Sex chromosome / Sperm / Molecular Evolutionary rate / 突然変異率 / 同義置換 / 生殖細胞 / 分進化
Research Abstract

Under the assumption that errors in DNA replication are the major source of mutations that contribute to molecular evolution, we showed that different numbers of germ-cell division between males and females result in different mutation frequencies between autosomes and sex chromosomes. The expected mutation frequency, R_<X/A>, of X chromosome and that, R_<Y/A>, of Y chromosome relative to the mutation frequency of autosomes were shown to be 2/3 and 2 in the XX female/XY male system, respectively, if male to female ratio of the number of germ-cell divisions (alpha) is very large. To test this, we compared nucleotide sequences of autosome- and X-linked genes between human and mouse(or rat) and analyzed the evolutionary rates of silent substitutions. The average rate of silent substitutions of X-linked genes relative to that of autosome-linked genes (R^'_) was shown to be 0.58, being close to the expected value 2/3. For the relative evolutionary rate R^'_ of a Y-linked gene, we observed R^'_=2.2, which again is close to the expected value 2. From the strong correlation between the observed R' and the expected R for alpha>>1, we proposed that males possibly serve as a mutation generator. We also found that, in X-linked genes, the rate of pseudogene evolution is 1.54 times as high as their functional counterpart and rodents evolve at 2.3 times the rate of non-rodent mammals. These properties agree well quantitatively with those found in autosomal genes, suggesting uniformly reduced mutation frequency over the whole X chromosomal regions. The relative mutation frequencies of the ZW female/ZZ male system were shown to be a reversal of those of XX/YY system: For alpha>>1, R_<Z/A>(=4/3)>1>>R_<W/A>. A very small value of R_<w/A> is expected. An analysis of avian genes would provide a clear-cut proof of this model.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Miyata,T.: "Male-driven molecular evolution:A model and uncleotide sequence analysis." Cold Spring Harbor Symp.Quanti. Biol.LII. 863-867 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miyata,T.: "Male-driven molecular evolution demonstrated by different rates of silent substitutions between autosome- and sex chromosome- linked genes." Proc. Japan Acad.63B. 327-331 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kuma,K.: "Limited divergence of X-linked gene:Further supporting evidence for male-driven molecular evolution." Proc. Japan Acad.63B. 332-335 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miyata,T.: "Different rates of evolution of autosome-,X chromosome- and Y chromosome-liked genes:Hypothesis of male-driven molecular evolution." In:Population Biology of Genes and Molecules(Takahata, N.& Crow, J.F. eds.). 341-357 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Iwabe,N.: "Evolutionary relationship of archaebacteria, eubacteria and eukaryotes inferred from phylogenetic tree of duplicated genes." Proc. Natl. Acad.Sci.USA. 86. 9355-9359 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 宮田隆: "進化は雄で決まるか" 科学(岩波書店). 59. 137-144 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miyata, T.: "Male-driven molecular evolution: A model and nucleotide sequence analysis." Cold Spring Harbor Symp. Quanti. Biol. Vol.LII, 863-867, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miyata, T.: "Male-driven molecular evolution demonstrated by different rates of silent substitutions between autosome- and sex chromosome- linked genes." Proc. Japan Acad. Vol.63B, 327-331, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kuma, K.: "Limited divergence of X-linked gene: Further supporting evidence for male-driven molecular evolution." Proc. Japan Acad. Vol.63B, 332-335, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Iwabe, N.: "Evolutionary relationship of archaebacteria, eubacteria and eukaryotes inferred from phylogenetic tree of duplicated genes." Proc. Natl. Acad. Sci. USA Vol.86, 9355-9359, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miyata, T.: "Different rates of evolution of autosome-, X chromosome- and Y chromosome-linked genes: Hypothesis of male-driven molecular evolution." In: Population Biology of Genes and Molecules. (eds. Takahata, N. Crow, J. F.) 341-357, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miyata,T.: "Different rates of evolution of autosome-,X chromosome-and Y chromosome-liked genes:Hypothesis of male-driven molecular evolution." In:Population Biology of Genes and Molecules(eds.Takahata,N.& Crow,J.F.). 341-357 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Iwabe,N.: "Evolutionary relationship of archaebacteria,eubacteria and eukaryotes inferred from phylogenetic tree of duplicated genes." Proc.Natl.Acad.Sci.USA. 86. 9355-9359 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Iwabe,N.: "Evolution of rhodopsin supergene family:-Independent divergence of visual pigments in vertebrates and insects and possibly in mollusks." Proc.Japan Acad.65B. 195-198 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kishino,H.: "Maximum likelihood inference of protein phylogeny,and the origin of chloroplasts." J.Mol.Evol.(1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 宮田隆: "進化は雄で決まるか" 科学(岩波書店). 59. 137-144 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Harata: J.Biol.Chem.263. 13952-13961 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] N.Uryu: Poultry Sci.

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Miyata: Cold Spring Harbor Symp.Quanti.Biol.LII. 863-867 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] K.Kuma: Jpn.J.Genet.63. 367-371 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Sekiguchi: EMBO J.7. 1683-1687 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] T.Miyata: Proceedings of the Foarth International Symposium on Population Biology of Genes and Molecules.

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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