| Project/Area Number |
63480091
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
基礎獣医学
|
|---|
| Research Institution | Osaka Prefecture University |
|---|
Principal Investigator |
YAMAUCHI Shoji Univ. Osaka Pref., Coll. Agric., Professor, 農学部, 教授 (80081503)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KISO Yasuo Univ, Osaka Pref., Coll. Agric. Assis. Prof., 農学部, 助手 (10142374)
SASAKI Fumihiko Univ. Osaka Pref., Coll. Agric., Assoc. Prof., 農学部, 助教授 (60064862)
岡田 利也 大阪府立大学, 農学部, 助手 (00169111)
|
|---|
| Project Period (FY) |
1988 – 1990
|
| Project Status |
Completed (Fiscal Year 1990)
|
| Budget Amount *help |
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1988: ¥4,100,000 (Direct Cost: ¥4,100,000)
|
|---|
| Keywords | Fetoーplacental unit / Fetal endocrine glands / Morphology of placenta / Endocrine activity of placenta / Maintenance of pregnancy / 胎子-胎盤系 / 胎盤内分泌機能 |
|---|
| Research Abstract |
1. Macroscopical and scanning electron microscopical investigations on a placental vasular architecture by means of the resin injection were undertaken. General vascular architectures, chronological changes during pregnancy and species differences due to the placental types were clarified in fetal placenta of the cow, maternal and fetal placentae of the bitch and maternal placenta of the suncus.
2. In addition to the microscopical and electron microscopical study on the histogenesis of the porcine fetal hypophysis, an enzyme immunological investigation by means of antibodies for ACTH, GH, LH, and PRL was also undertaken. Stages of an appearance of each gland cell in the anterior pituitary gland were clarified. Furthermore, the characteristics of the distribution pattern of each gland cell during the fetal life were also clarified.
3. Zonation and the endocrine activity of the fetal porcine adrenal gland were clarified by means of the histometry as well as the investigation on activities for hydroxysteroid dehydrogenase (HSD). In an early fetal stage, the adrenal gland was mainly consisted from cells of the fetal cortex. In a latter half of pregnancy, a definitive cortex particularly the zona fasciculate developed progressively. Meanwhile, the fetal cortex involuted gradually. Both the fetal cortex and the zona fasciculata showed the similar activities for HSD, hence the important role relating to a feto-placental unit was suspected.
4. Histometry, a detection for HSD activities and an electron microscopical investigations were undertaken on a histogenesis of the fetal cat adrenal gland. In a case of the cat, cells of the fetal cortex did not show a sign of involution even in a late stage of pregnancy. Instead, the fetal cortex as seemed to be incorporated into the zona reticularis. Accordingly, the fetal cortex seemed to play a role up to the middle of pregnancy and the zona fasciculata succeeds thereafter.
|
