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Studies on modification of alcoholic liver disease by dietary carbohydrate and fat

Research Project

Project/Area Number 63480179
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionShinshu University

Principal Investigator

MURAYAMA Ninzo  Shinshu University, 医学部, 教授 (90020718)

Co-Investigator(Kenkyū-buntansha) OKUYAMA Shusaku  信州大学, 医学部, 助手 (40152441)
那須 民江  信州大学, 医学部, 講師 (10020794)
NASU-NAKAJIMA Tamie  
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥4,100,000 (Direct Cost: ¥4,100,000)
Fiscal Year 1989: ¥1,100,000 (Direct Cost: ¥1,100,000)
Fiscal Year 1988: ¥3,000,000 (Direct Cost: ¥3,000,000)
KeywordsEthanol / Hepatotoxicity / Lipid peroxidation / Carbohydrate / GAMMA-glutamyl transpeptidase / Triglyceride / Transaminase / Glutathione / 蛋白質 / 脂肪 / コレステロ-ル / アルコール性肝障害 / チトクロームPー450 / 赤血球溶血反応
Research Abstract

The effects of dietary carbohydrate (CHO) level on lipid peroxidation caused by ethanol were investigated in rat liver. Ethanol treatment enhanced microsomal ethanol oxidation, which was potentiated by lowered CHO intake. Ethanol administration markedly increased lipid peroxidation and triglyceride content in the liver of rats fed with low-CHO diet, and slightly in rats fed with high-CHO diet: lipid peroxidation and triglyceride accumulation caused by ethanol were potentiated by low-CHO diet. Liver glutathione content was decreased not by ethanol intake but by lowered CHO intake. These results suggest that lowered-CHO intake involves in the development of ethanol-induced hepatic damage in rats.
In order to investigate the effect of CHO intake on ethanol induced hepatic damage, liver function, frequencies of various food and alcohol intakes were surveyed in 2165 healthy men aged from 18 to 85 living in Nagano Prefecture. Serum gamma-glutamyl transpeptidase (gamma-GTP), glutamic-oxaloacetic transaminase(GOT), glutamate pyruvic transaminase(GPT) activities, ratio of GOT to GPT, triglyceride and HDL-cholesterole increased with increasing ethanol consumption. In contrast, the ratio of HDL to LDL de creased with increasing ethanol consumption. The intake of CHO clearly decreased with increasing ethanol consumption, but the intake of fat and protein not found to increase or decrease evidently following ethanol consumption. With ethanol intakeadjusted analysis, lowered- CHO intake may potentiate ethanolinduced increase in serum -GTP activity. We deduced that CHO intake contributes to l-induced hepatic damage.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] 中島民江,井勝久喜,王瑞生,沖野知範他: "肝過酸化脂質に対するアルコ-ルと糖質の相互作用" アルコ-ル代謝と肝. 8. 62-67 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 中島民江,太田節子,村山忍三,釘本完: "アルコ-ル飲用者の栄養摂取状況について" 日本衛生学雑誌(準備中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 中島民江,太田節子,村山忍三,釘本完: "アルコ-ル飲用者のコレステロ-ル値におよぼす栄養因子について" 日本衛生学雑誌(準備中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Nakajima,E.Elovaara and H.Vanio: "Monoclonal antibody-derected detection of lowered carbohydrate diet- and ethanol-induced eytochrome P450 isozymes" J.Nutr.(in preparation).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Nakajima,S.Ohta,N.Murayama: "Dietary carbohydrate as a modifying factor for the development of alcoholic liver disease" J.Nutr.(in preparation).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Nakajima,S.Ohta,N.Murayama: "Dietary carbohydrate as a modifying factor for the development of ethanolinduced diabetic disease" J.Nutr.(in preparation).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Nakajima, H. Ikatsu, RS Wang, T. Okino, N. Murayama, I. Yonekura, A. Sato: "Modification of ethanol-induced lipid peroxidation by low carbohydrate" Alcohol Metabolism and the Liver 8: 62-67 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Nakajima, S. Ohta, N. Murayama, M. Kuginoto: "Nutritional condition in men and women of drinking habit." Jpn J Hyg.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Nakajima, S. Ohta, N. Murayama, M. Kuginoto: "Effects of nutrition on cholesterol level following drinking." Jpn J Hyg.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Nakajima, E. Elovaara and H. Vainio: "Monoclonal antibody-directed detection of lowered carbohydrate diet- and ethanol-induced cytochrome P450 isozymes" J Nutr.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Nakajima, S. Ohta, N. Murayama, A. Sato: "Dietary carbohydrate as a modifying factor for the development of alcoholic liver disease" J Nutr.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T. Nakajima, S. Ohta, N. Murayama, A. Sato: "Dietary carbohydrate as a modifying factor for the development of ethanol-induced diabetic disease" J Nutr.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] T.Nakajima,S.Ohota,N.Murayama,A.Sato.: "Dietary carbohydrate as a modifying factor for the development of alcoholic liver disease" J.Nutr.

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Nakajima,S.Ohota,N.Murayama,A.Sato.: "Dietary carbohydrate as a modifying factor for the development of ethanol-induced diabetic disease" J.Nutr.

    • Related Report
      1989 Annual Research Report
  • [Publications] 中島民江,太田節子,村山忍三,佐藤章夫: "アルコ-ル飲用者のコレステロ-ル値におよぼす栄養因子について" 日本衛生学雑誌.

    • Related Report
      1989 Annual Research Report
  • [Publications] T.Nakajima;H.Ikatsu;T.Okino;N.Murayama;I.Yonekura;A.Sato: J.Nutr.

    • Related Report
      1988 Annual Research Report
  • [Publications] 中島民江,井勝久喜,王瑞生,沖野知範,村山忍三,米倉郁美,佐藤章夫: "アルコール代謝と肝" 「アルコール代謝と肝」研究会, (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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