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Vertical and Horizontal Infection of Hepatitis B Virus in Adult Twins

Research Project

Project/Area Number 63480185
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionKinki University

Principal Investigator

SHIMIZU Tadahiko  Kinki University, Public Health, Professor, 医学部・公衆衛生学教室, 教授 (00088519)

Co-Investigator(Kenkyū-buntansha) YURA Akiko  same as the above, Assistant, 医学部・公衆衛生学教室, 助手 (80142595)
MITO Hideki  same as the above, Instructor, 医学部・公衆衛生学教室, 講師 (00101402)
HAYAKAWA Kazuo  same as the above, Instructor, 医学部・公衆衛生学教室, 講師 (70142594)
大国 美智子  近畿大学, 医学部公衆衛生学, 助教授 (90088542)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1988: ¥2,400,000 (Direct Cost: ¥2,400,000)
KeywordsTwin / Hepatitis B virus / Vertical infection / Horizontal infection / 感染様式 / HB肝炎 / 感染経路 / 疫学調査
Research Abstract

The mailed-questionnaire survey was conducted on 1080 pairs of twins. Among these twin subjects, 170 pairs were the subjects newly collected in 1988 in Osaka Prefecture. Besides the questionnaire survey, comprehensive medical examination was conducted for the 144 pairs of volunteer twins. The medical examination included the serological tests on Hepatitis B virus antigen (HBs, HBc) and antibody (HBs, HBc, HBe), and the other tests on liver function (r-GPT, GOT, GPT, etc.). At the same time, a personal interview was also conducted on their lifestyle and environmental factors. The data was analyzed in gemellological methods, and the following results were obtained.
[ RESULT ]
1) If HBc antibody positive is seen as the index to indicate the past infection, 37.5% of the subjects were infected by HB virus in the past. The estimated rate of infection was 18.3% on vertical infection and 22.9% on horizontal infection. There was no difference between monozygotic and dizygotic, although the male twin subjects showed a slightly high rate of horizontal infection.
2) On comparison of infection rates by birth time, the twins born in 1920's showed the highest rate of infection (49.1), followed by the rate 38.3% of the twins born in 1910's to 20.7% of the twins born in 1930^'s. This result indicates that HB virus was spread among the present elderly population and then vertically transmitted to the next generation.
3) On the other serological tests concerning liver functions, r-GPT tended to show a high score in the pairs in which both members were infected by HB virus. On the comparison of twins who showed 30 IU/1 or higher in r-GPT, the pairs in which both members were infected showed the higher rate (37.5%) of elevated values of r-GPT than the rate (21.9%) of the pairs in which only one member was infected. r-GPT may be seen as an index of prognosis of vertical infection.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 早川 和生: "成人双生児の血清脂質・電解質濃度等に関与する遺伝・環境要因の相対的強度の検討" 日本衛生学雑誌. 43. 763-777 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kazuo Hayakawa: "Blood pressure discordance and lifestyle:Japanese identical twins reared apart and together" Acta Geneticae Medicae et Gemellologiae. 36. 486-491 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kazuo Hayakawa: "Smoking and drinking discordance and health condition:Japanese identical twins reared apart and together" Acta Geneticae Medicae et Gemellologiae. 36. 493-501 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 清水 忠彦: "成人双生児の血清脂質・血圧値の遺伝寄与率" 医学のあゆみ. 147. 760 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 和生: "成人双生児研究法による遺伝・環境要因の相対的強度の研究" 日本衛生学雑誌. 45. 121-124 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 和生: "血清脂質は遺伝・環境要因のどちらの影響を強く受けるか" 医学のあゆみ. 153. 88 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 和生: "“双生児健康研究における遺伝と環境"in“ライフスタイルと健康"(森本兼襄編)" 医学書院, (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 早川 和生: "成人双生児研究法による遺伝・環境要因の相対的強度の研究" 日本衛生学雑誌. 45. 121-124 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 和生: "血清脂質は遺伝・環境要因のどちらの影響を強く受けるか" 医学のあゆみ. 153. 88 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川 和生: "“双生児健康研究における遺伝と環境"in“ライフスタイルと健康"(森本兼襄編)" 医学書院, (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 早川和生,由良晶子,堀川隆志,大城治: "中高年齢に達した双生児を用いた身体生理的老化現象と生活行動要因の検討" デサント・スポ-ツ科学. 10. 40-46 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大木秀一,浅香昭雄,早川和生,清水忠彦: "質問紙法による双生児の卵性診断" 民族衛生. 55. 227-235 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 早川和生,清水忠彦,大城治,大国美智子他: "中高年双生児における血液像の検討" 日本衛生学雑誌. 44. 494 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hayakawa.K,Shimizu.T,Oshiro.O: "Intrapir differenes of blood pressure levels and personality in adult identical twins" Acta Genetica Medicae et Gemellologiae. 38. 224 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大城治,早川和生,三戸秀樹,由良晶子: "双生児の健康状況ー全年齢層についてのアンケ-ト調査成績ー" 日本公衆衛生雑誌. 36. 141 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 早川和生,清水忠彦: "「双生児研究」in「ライフスタイルと健康」" 医学書院, (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 早川和生: 日本衛生学雑誌. 43. 763-777 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kazuo Hayakawa,Tadahiko Shimizu.: Acta Geneticae Medicae et Gemellologiae. 36. 486-491 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 清水忠彦、早川和生: 医学の歩み. 147. 760 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 清水忠彦、早川和生、大国美智子、三戸秀樹 他: 日本衛生学雑誌. 43. -589 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 早川和生、清水忠彦: "双生児研究における遺伝と環境、in「ライフスタイルと健康」" 医学書院,

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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