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Age-related alteration of immune functions in humans and its relation to autoimmunity

Research Project

Project/Area Number 63480191
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionShimane Medical University

Principal Investigator

SAKANE Tsuyoshi  Shimane Medical University, 医学部, 助教授 (40127519)

Co-Investigator(Kenkyū-buntansha) UEDA Yuji  島根医科大学, 医学部附属病院, 医員
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsaging / autoimmunity / B cell activation / neutrophils / chemotaxis / oxygen radicals / natural killer cells / TCRαβ^+CD4^-CD8^-T細胞 / CD5^+B細胞 / 好中球機能 / NK活性 / リンパ球活性化機序 / T細胞 / B細胞 / 全身性エリテマトーデス / パーコール不連続比重遠心法 / CD3抗体
Research Abstract

We evaluated B lymphocyte function in 24 elderly (mean 79.3 yr.) and 14 young (mean 24.5 yr.) persons. Lymphocytes from elderly persons incorporated significantly less tritiated thymidine as compared with lymphocytes from young persons when stimulated with Staphylococcus aureus Cowan I. Moreover, the elderly persons were found to have elevated numbers of cells spontaneously secreting immunoglobulin (Ig). However, lymphocytes from elderly persons stimulated with pokeweed mitogen displayed Ig production equal to young persons. The results in elderly persons are consistent with polyclonal B cell activation in vivo.
Neutrophils from 25 elderly persons (70 to 80 yr.) and from 15 young persons (<50 yr.) were next investigated for their ability to produce chemotactic activity, phagocytic activity and oxygen intermediates. Neutrophils from old donors produced less chemotactic activity than did neutrophils from young donors. In contrast, phagocytic activity and production of oxygen intermediates by neutrophils from young and old donors were comparable. The selective failure in the chemotaxis of neutrophils associated with aging could contribute to the increase with age in the incidence of infectious diseases.
Because of the increase with age in the incidence of neoplasia, one can expect impaired NK activity in aged humans. However, increase in NK activity was demonstrated in groups aged 71 to 75, 76 to 80 and 81 to 85, although groups of 65 to 70 years and more than 86 years showed a comparable NK activity to that in young persons (18 to 50 years). The difference in observed NK activity could not be attributed to differences in percentage of NK cells in the blood from old and young persons. Increase with age in the NK activity may make up the decline of immunologic competence with age for maintaining normal immune system homeostasis.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (185 results)

All Other

All Publications (185 results)

  • [Publications] Sakane,T.: "B cell hyperactivity and its relation to distinct clinical features and the degree of disease activity in patients with systemic lupus erythematosus." Arthritis Rheum.31. 80-87 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki,N.: "Differential mechanism for differentiation into immunoglobulinsecreting cells in human resting B lymphocyte subsets isolated on the basis of cell density." J.Clin.Invest.81. 261-269 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki,N.: "Mechanism of T cell-derived helper factor production upon stimulation with pokeweed mitogen in humans." Clin.Exp.Immunol.71. 343-349 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 山内康平: "SLEにおける補体系・免疫系異常" 臨床リウマチ. 1. 28-35 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane,T.: "Induction of B cell hyperactivity by an in vitro stimulus in culture in patients with systemic lupus erythematosus.(abstract)" FASEB J.2. A1676 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ueda,Y.: "B cell subset(s)responsible for B cell hyperactivity and autoantibody production in patients with systemic lupus erythematosus(SLE).(abstract)" FASEB J.2. A1670 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 三木知博: "慢性甲状腺炎(橋本病)に無症候性原発性胆汁性肝硬変の所見を呈し、甲状腺ホルモン薬の投与にて改善をみた1例。" 日本内科学会雑誌. 77. 524-529 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Niwa,Y.: "The effect of aging on cutaneous lipid peroxide levels and superoxide dismutase activity in guinea pigs and patients with burns." Life Sciences. 42. 351-356 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Niwa,Y.: "Methyltransferase and phospholipase A_2 activity in the cell membrane of neutrophils and lymphocytes from patients with Behcet's disease,systemic lupus erythematosus,and rheumatoid arthritis." Clinica Chim.Acta. 174. 1-14 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tsuchida,T.: "Intracellular activation signal requirements for the induction of interleukin 2 responsiveness in resting T cell subsets in humans." J.Immunol.140. 3446-3449 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Murakawa,Y.: "Deficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate." Arthritis Rheum.31. 826-833 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 村川洋子: "Carcinoembryonic antigen(CEA)産生性肺癌に結節性多発動脈炎を合併し、病巣血管壁にCEAの局在を認めた1症例。" 日本臨床免疫学会会誌. 12. 107-113 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane,T.: "Possible involvement of the CD4 molecule in a late activation eventon CD4^+ T cell proliferation in the human autologous mixed lymphocyte reaction." Clin.Exp.Immunol.75. 269-274 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki,N.: "Induction of excessive B cell proliferation and differentiation by an in vitro stimulus in cultrue in human systemic lupus erythematosus." J.Clin.Invest.83. 937-944 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane,T.: "Familial occurrence of impaired interleukin 2 activity and increased peripheral blood B cells actively secreting immunoglobulin in systemic lupus erythematosus." Am.J.Med.86. 385-390 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeno,M.: "Clinical and immunologic characteristics of systemic lupus erythematosus(SLE)with selective IgM deficiency(abstract)" Arthritis Rheum.32(4,suppl.). S92 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 上田裕司: "全身性エリテマト-デス患者におけるB細胞異常活性化に関する研究:活性化B細胞によるリンホカインに対する過剰反応。" 内科宝函. 36. 153-160 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 上田裕司: "SLE治療の現況:B細胞異常活性の成立機序を考慮した治療法。" 日本臨床免疫学会会誌. 12. 550-553 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ueda,Y.: "Hyperreactivity of activated B cells to B cell growth factor in patients with systemic lupus erythematosus." J.Immunol.143. 3988-3993 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki,N.: "Anti-DNA antibody production by CD5^+ and CD5^- B cells of patients with systemic lupus erythematosus." J.Clin.Invest.85. 238-247 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki,N.: "Effects of novel immunosuppressive agent,FK506 on human B cell activation." Clin.Exp.Immunol.79. 240-245 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "免疫系細胞の病態を考慮した治療法。" リウマチ(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "研究と実験:ヒト全身性エリテマト-デス(SLE)におけるB細胞異常活性の成立機序。" 病態生理. 7. 59-61 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "ベ-チェット病における好中球機能亢進の機序--特にリンパ球の役割:ベ-チェット病における免疫異常。" 最新医学. 43. 312-320 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 板根剛: "自己免疫病:自己免疫病発症の細胞免疫学的機序" 日本臨〓. 46. 755-763 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "全身性エリテマト-デスの発生機序" 医学のあゆみ. 145. 96 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "SLE-病態解明の現況:免疫異常素因-リンパ球機能よりの解析" 臨床免疫. 29. 344-354 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 高田伸介: "Q&A:CNSル-プスの治療" 腎と透析. 25. 907-908 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 高田伸介: "SLEにみられる生体防御の異常反応" 生体防御. 5. 199-210 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "リウマチ性疾患の免疫学的発症要因:免疫細胞" 臨床免疫. 21(suppl.14). 25-34 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "細胞の検査法と臨床的意義:総論" 臨床免疫. 21(suppl.14). 377-379 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "細胞の検査法と臨床的意義:リンパ球の検索--サブセット、機能。" 臨床免疫. 21(suppl.14). 380-395 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "インタ-ロイキンの注目すべき側面:ヘルパ-T細胞、サプレッサ-T細胞のIL-2反応性の相違。" 臨床免疫. 21. 486-496 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "今日の考え方:免疫学的にみたリウマチ性疾患" リウマチ科. 1. 406-414 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "フェルティ症候群" 現代医療. 21. 1345-1350 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 高田伸介: "活性化T細胞におけるCD3/Ti抗原レセプタ-分子とCD4分子のco-modulation." Medical Immunology. 17. 505-514 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "レセプタ-異常と免疫病:サイトカインレセプタ-と自己免疫病" 臨床免疫. 21. 841-858 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "発症の免疫学的機序に関する最近の考え方:全身性エリテマト-デス" 臨床医. 15. 1700-1705 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岳野光洋: "血管炎:アレルギ-性肉芽腫性血管炎" 現代医療. 21. 3337-3343 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "LE細胞テスト" 日本臨〓1990年増刊「広範囲血液・尿化学検査、免疫学的検査」. 下巻. 513-518 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岳野光洋: "免疫--病態から分子へ:III自己免疫疾患4.レセプタ-異常--T細胞抗原認識レセプタ-を中心にして" 蛋白質核酸酵素. 35. 865-873 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 高久史麿: "膠原病--成因と治療(座談会)" 内科(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 小谷宏行: "自己抗体検査法.LE細胞" 日本臨〓(1990年増刊号,臨床免疫),(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 小谷宏行: "自己免疫の発生機序:T細胞の異常" 日本臨〓(1990年増刊号,臨床免疫),(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 岳野光洋: "自己免疫疾患:自己免疫疾患発症の細胞免疫学的機序" 日本臨〓(1990年増刊号,臨床免疫),(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "HLAとMHC:各種疾患とHLA抗原:SLE" 日本臨〓(1990年増刊号,臨床免疫),(印刷中).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "炎症と血球:リンパ球,リウマチ学の研究(塩川優一,七川歓次,御巫清允,本間光夫監修)" 同文書院, 11 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "主訴から考えるリウマチ・膠原病:不整脈,心不全,図説内科診断治療講座第12巻リウマチ性疾患(安倍達編)" メジカルビュ-社, 6 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "T細胞サプレッション。最新免疫学(山村雄一編)" 同文書院, 21 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 坂根剛: "T細胞とその機能,免疫・炎症・膠原病--その基礎,臨床,治療--(水島裕編),(印刷中)" メディカル葵出版,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "B cell hyperactivity and its relation to distinct clinical features and the degree of disease activity in patients with systemic lupus erythematosus." Arthritis Rheum., 31-1, 80-87, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki, N.: "Differential mechanism for differentiation into immunoglobulin-secreting cells in human resting B lymphocyte subsets isolated on the basis of cell density." J. Clin. Invest., 81-1, 261-269, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki, N.: "Mechanism of T cell-derived helper factor production upon stimulation with pokeweed mitogen in humans." Clin. Exp. Immunol., 71-2, 343-349, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamauchi, Y.: "Abnormality of the immune system and the complement system in systemic lupus erythematosus." Clin. Rheumatol., 1, 28-35, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Induction of B cell hyperactivity by an in vitro stimulus in culture in patients with systemic lupus erythematosus." FASEB J., 2-6, A1676, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ueda, Y.: "B cell subset(s) responsible for B cell hyperactivity and autoantibody production in patients with systemic lupus erythematosus (SLE)." FASEB J., 2-6, A1670, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Miki, T.: "Development of asymptomatic primary biliary cirrhosis in a patient with Hashimoto's thyroiditis and improvement of the liver disease by treatment of the thyroiditis." J. Jap. Soc. Intern. Med., 77-4, 524-529, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Niwa, Y.: "The effect of aging on cutaneous lipid peroxide levels and superoxide dismutase activity in guinea pigs and patients with burns." Life Sciences, 42, 351-356, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Niwa, Y.: "Methyltransferase and phospholipase A_2 activity in the cell membrane of neutrophils and lymphocytes from patients with Behcet's disease, systemic lupus erythematosus, and rheumatoid arthritis." Clinica Chim. Acta, 174-1, 1-14, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tsuchida, T.: "Intracellular activation signal requirements for the induction of interleukin 2 responsiveness in resting T cell subsets in humans." J. Immunol., 140-10, 3446-3449, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Murakawa, Y.: "Deficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate." Arthritis Rheum., 31-7, 826-833, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Murakawa, Y.: "A case of carcinoenbryonic antigen (CEA)-producing lung cancer associated with polyarteritis nodosa, with special reference to deposition of CEA in the affected vessels." Jpn. J. Clin. Immun., 12-1, 107-113, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Possible involvement of the CD4 molecule in a late activation event on CD4^+ T cell proliferation in the human autologous mixed lymphocyte reaction." Clin. Exp. Immunol., 75-2, 269-274, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki, N.: "Induction of excessive B cell proliferation and differentiation by an in vitro stimulus in culture in human systemic lupus erythematosus." J. Clin. Invest., 83-3, 937-944, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Familial occurrence of impaired interleukin 2 activity and increased peripheral blood B cells actively secreting immunoglobulin in systemic lupus erythematosus." Am. J. Med., 86-4, 385-390, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeno, M.: "Clinical and immunologic characteristics of systemic lupus erythematosus (SLE) with selective IgM deficiency." Arthritis Rheum., 32(4, suppl.), S92, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ueda, Y.: "B cell hyperactivity in patients with systemic lupus erythematosus: enhanced responsiveness of activated B cells to lymphokine-derived signals." Jpn. Arch. Int. Med., 36-5, 153-160, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ueda, Y.: "Possible therapy for SLE with special reference to mechanism of B cell hyperactivity." Jpn. J. Clin. Immun., 12-5, 550-553, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ueda, Y.: "Hyperreactivity of activated B cells to B cell growth factor in patients with systemic lupus erythematosus." J. Immunol., 143-12, 3988-3993, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki, N.: "Anti-DNA antibody production by CD5^+ and CD5^- B cells of patients with systemic lupus erythematosus." J. Clin. Invest., 85-1, 238-247, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Suzuki, N.: "Effects of novel immunosuppressive agent, FK506 on human B cell activation." Clin. Exp. Immunol., 79-2, 240-245, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Possible therapy for autoimmune diseases on the basis of pathogenesis of immune-competent cells." Ryumachi.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Possible mechanism of B cell hyperactivity in human systemic lupus erythematosus." Pathophysiology, 7-1, 59-61, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Immune abnormalities in Behcet's disease." Saishin-Igaku, 43-2, 312-320, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Cellular and immune mechanism for development of autoimmune diseases." Jap. J. Clin. Med., 46-4, 755-763, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Mechanism for development of systemic lupus erythematosus." J. Clin. Exp. Med. (Igaku no Ayumi), 145-2, 96, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Familial abnormalities of lymphocyte function in systemic lupus erythematosus." Clin. Immunol., 29-4, 344-354, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takada, S.: "Therapy for CNS lupus." Jin to Toseki, 25, 907-908, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takada, S.: "Abnormalities of immune response in systemic lupus erythematosus." Host Defense, 5-2, 199-210, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Role of immune competent cells in the pathogenesis of autoimmune disease." Clin. Immunol., 21(suppl. 14), 25-34, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Methods for identification of immune competent cells and measure of their function, and their significance for clinical practice: general remarks." Clin. Immunol., 21(suppl. 14), 377-379, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Lymphocytes: subsets and function." Clin. Immunol., 21(suppl. 14), 380-395, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Differential responsiveness of helper and suppressor T cells to interleukin 2." Clin. Immunol., 21-4, 486-496, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Immunological clues to the etiology of rheumatic diseases." Rheumatology, 1-4, 406-414, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Felty's syndrome." Gendai Iryo, 21-5, 1345-1350, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takada, S.: "CD4 molecules are associated with the CD3/Ti complex on activated T cell." Med. Immunol., 17-5, 505-514, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Role of abnormal expression and function of cytokine receptors in the pathogenesis of autoimmune disease." Clin. Immunol., 21-6, 841-858, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Current topics of immune mechanism for development of systemic lupus erythematosus." Med. Clinics Jap., 15-10, 1700-1705, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeno, M.: "Allergic granulomatous Angiitis." Gendai Iryo, 21-12, 3337-3343, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "LE cell test." Jap. J. Clin. Med. (suppl. 1990), 513-518, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeno, M.: "The T cell receptor abnormalities and autoimmune diseases." Proteins, Nucleic Acids and Enzymes.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takaku, F.: "Pathogenesis of, and treatment for, collagen diseases." Intern. Med.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kotani, H.: "LE cell." Jap. J. Clin. Med.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kotani, H.: "Pathogenesis of autoimmunity: role of T cell abnormalities in the autoimmunity." Jap. J. Clin. Med.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takeno, M.: "Cellular basis for the development of autoimmune diseases." Jap. J. Clin. Med.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Association of HLA with SLE." Jap. J. Clin. Med.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Arrhythmia and heart failure in collagen diseases." Illustrated Internal Medicine Vol.12, Rheumatic Disease (ed. by Abe, T.) Medical View, Tokyo, pp.80-85, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "Inflammation and blood cells: lymphocytes." Rheumatology (ed. by Shiokawa, Y.), Dobun Shoin, Tokyo, pp.162-172, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "T cell suppression." Immunology (ed. by Yamamura, Y.), Dobun Shoin, Tokyo, pp.143-163, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakane, T.: "T cells and their function." Immunology, Inflammation and Collagen Disease (ed. by Mizushima, Y.), Medical Aoi, Tokyo.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 村川洋子: "Carcinoembryonic antigen(CEA)産生性肺癌に結節性多発動脈炎を合併し、病巣血管壁にCEAの局在を認めた1症例" 日本臨床免疫学会会誌. 12. 107-113 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakane,T.: "Possible involvement of the CD4 molecule in a late activation event on CD4^+ T cell proliferation in the human autologous mixed lymphocyte reaction." Clin.Exp.Immunol.75. 269-274 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Suzuki,N.: "Induction of excessive B cell proliferation and differentiation by an in vitro stimulus in culture in human systemic lupus erythematosus." J.Clin.Invest.83. 937-944 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakane,T.: "Familial occurrence of impaired interleukin 2 activity and increased peripheral blood B cells actively secreting immunoglobulin in systemic lupus erythematosus." Am.J.Med.86. 385-390 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takeno,M.: "Clinical and immunologic characteristics of systemic lupus erythematosus(SLE)with selective IgM deficiency." Arthritis Rheum.32(4,suppl.). 4 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 上田裕司: "全身性エリテマト-デス患者におけるB細胞異常活性化に関する研究:活性化B細胞によるリンホカインに対する過剰反応" 内科宝函. 36. 153-160 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 上田裕司: "SLE治療の現況:B細胞異常活性の成立機序を考慮した治療法" 日本臨床免疫学会会誌. 12. 550-553 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ueda,Y.: "Hyperreactivity of activated B cells to B cell growth factor in patients with systemic lupus erythematosus." J.Immunol.143. 3988-3993 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Suzuki,N.: "Anti-DNA antibody production by CD5^+ and CD5^- B cells of patients with systemic lupus erythematosus." J.Clin.Invest.85. 238-247 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Suzuki,N.: "Effects of novel immunosuppressive agent,FK506 on human B cell activation." Clin.Exp.Immunol.79. 240-245 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "免疫系細胞の病態を考慮した治療法" リウマチ.

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "リウマチ性疾患の免疫学的発症要因:免疫細胞" 臨床免疫. 21(suppl.14). 25-34 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "細胞の検査法と臨床的意義:総論" 臨床免疫. 21(suppl.14). 377-379 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "細胞の検査法と臨床的意義:リンパ球の検索ーーサブセット,機能" 臨床免疫. 21(suppl.14). 380-395 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "インタ-ロイキンの注目すべき側面:ヘルパ-T細胞,サプレッサ-T細胞のILー2反応性の相違" 臨床免疫. 21. 486-496 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "今日の考え方:免疫学的にみたリウマチ性疾患" リウマチ科. 1. 406-414 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "フェルティ症候群" 現代医療. 21. 1345-1350 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 高田伸介: "活性化T細胞におけるCD3/Ti抗原レセプタ-分子とCD4分子のco-modulation" Medical Immunology. 17. 505-514 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "レセプタ-異常と免疫病:サイトカインレセプタ-と自己免疫病" 臨床免疫. 21. 841-858 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "発症の免疫学的機序に関する最近の考え方:全身性エリテマト-デス" 臨床医. 15. 1700-1705 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 岳野光洋: "血管炎:アレルギ-性肉芽腫性血管炎" 現代医療. 21. 3337-3343 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "LE細胞テスト" 日本臨牀,1990年増刊「広範囲血液・尿化学検査,免疫学的検査」. 下巻. 513-518 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 岳野光洋: "免疫ーー病態から分子へ:III自己免疫疾患4.レセプタ-異常ーーT細胞抗原認識レセプタ-を中心にして" 蛋白質 核酸 酵素.

    • Related Report
      1989 Annual Research Report
  • [Publications] 高久史麿: "膠原病ーー成因と治療(座談会)" 内科.

    • Related Report
      1989 Annual Research Report
  • [Publications] 小谷宏行: "自己抗体検査法.LE細胞" 日本臨牀(1990年増刊号,臨床免疫).

    • Related Report
      1989 Annual Research Report
  • [Publications] 小谷宏行: "自己免疫の発生機序:T細胞の異常" 日本臨牀(1990年増刊号,臨床免疫).

    • Related Report
      1989 Annual Research Report
  • [Publications] 岳野光洋: "自己免疫疾患:自己免疫疾患発症の細胞免疫学的機序" 日本臨牀(1990年増刊号,臨床免疫).

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "HLAとMHC:各種疾患とHLA抗原:SLE" 日本臨牀(1990年増刊号,臨床免疫).

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakane,T.: "B cell hyperactivity and its relation to distinct clinical features and the degree of disease activity in patients with systemic lupus erythematosus." Arthritis Rheum.31. 80-87 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Suzuki,N.: "Differential mechanism for differentiation into immunoglobulin-secreting cells in human resting B lymphocyte subsets isolated on the basis of cell density." J.Clin.Invest.81. 261-269 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Suzuki,N.: "Mechanism of T cell-derived helper factor production upon stimulation with pokeweed mitogen in humans." Clin.Exp.Immunol.71. 343-349 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 山内康平: "SLEにおける補体系・免疫系異常" 臨床リウマチ. 1. 28-35 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakane,T.: "Induction of B cell hyperactivity by an in vitro stimulus in culture in patients with systemic lupus erythematosus." FASEB J.2. A1676(abstract) (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ueda,Y.: "B cell subset(s)responsible for B cell hyperactivity and auto-antibody production in patients with systemic lupus erythematosus(SLE)." FASEB J.2. A1670(abstract) (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 三木知博: "慢性甲状腺炎(橋本病)に無症候性原発性胆汁性肝硬変の所見を呈し、甲状腺ホルモン薬投与にて改善をみた1例" 日本内科学会雑誌. 77. 524-529 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Niwa,Y.: "The effect of aging on cutaneous lipid peroxide levels and superoxide dismutase activity in guinea pigs and patients with burns." Life Sciences. 42. 351-356 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Niwa,Y.: "Methyltransferase and phospholipase A_2 activity in the cell membrane of neutrophils and lymphocytes from patients with Beh〓et's disease,systemic lupus erythematosus,and rheumatoid arthritis." Clinica Chim.Acta. 174. 1-14 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tsuchida,T.: "Intracellular activation signal requirements for the induction of interleukin 2 responsiveness in resting T cell subsets in humans." J.Immunol.140. 3446-3449 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Murakawa,Y.: "Deficient phytohemagglutinin-induced interleukin-2 activity in patients with inactive systemic lupus erythematosus is correctable by the addition of phorbol myristate acetate." Arthritis Rheum.31. 826-833 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "研究と実験:ヒト全身性エリテマト-デス(SLE)におけるB細胞異常活性の成立機序" 病態生理. 7. 59-61 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "ベ-チェット病における好中球機能亢進の機序ーー特にリンパ球の役割:ベ-チェット病における免疫異常" 最新医学. 43. 312-320 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "自己免疫病:自己免疫病発症の細胞免疫学的機序" 日本臨牀. 46. 755-763 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "全身性エリテマト-デスの発生機序" 医学のあゆみ. 145. 96 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "SLEー病態解明の現況:免疫異常素因ーリンパ球機能よりの解析" 臨床免疫. 29. 344-354 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 高田伸介: "Q&A:CNSル-プスの治療" 腎と透析. 25. 907-908 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 高田伸介: "SLEにみられる生体防御の異常反応" 生体防御. 5. 199-210 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "リウマチ学の研究(塩川優一,七川歓次,御巫清允,本間光夫監修)" 同文書院, 11 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "最新免疫学(山村雄一編)" 同文書院, 21 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "免疫・炎症・膠原病ーーその基礎,臨床,治療ーー(水島裕編)" メディカル葵出版,

    • Related Report
      1989 Annual Research Report
  • [Publications] 坂根剛: "図説内科診断治療講座 第12巻リウマチ性疾患(安倍達編)" メジカルビュ-社, 6 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakane,T.: Arthritis Rheum.31. 80-87 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Suzuki,N.: J.Clin.Invest.81. 261-269 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Suzuki,N.: Clin.Exp.Immunol.71. 343-349 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 山内康平: 臨床リウマチ. 1. 28-35 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 三木知博: 日本内科学会雑誌. 77. 524-529 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Niwa,Y.: Life Sciences. 42. 351-356 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Sakane,T.: Am.J.Med.

    • Related Report
      1988 Annual Research Report
  • [Publications] 上田裕司: 内科宝函.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 病態生理. 7. 59-61 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 最新医学. 43. 312-320 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 医学のあゆみ. 145. 96 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 日本臨牀. 46. 755-763 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Niwa,Y.: Clinica Chimica Acta. 174. 1-14 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Tsuchida,T.: J.Immunol.140. 3446-3449 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Murakawa,Y.: Arthritis Rheum.31. 826-833 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 村川洋子: 日本臨床免疫学会会誌. 12. 107-113 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Sakane,T,: Clin.Exp.Immunol.

    • Related Report
      1988 Annual Research Report
  • [Publications] Suzuki,N.: J.Clin.Invest.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 臨床免疫. 20. 344-354 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 高田伸介: 腎と透析. 25. 907-908 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 高田伸介: 生体防御. 5. 199-210 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 臨床免疫.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 臨床免疫. 印刷中.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 臨床免疫.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 臨床免疫.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: リウマチ科.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 現代医療.

    • Related Report
      1988 Annual Research Report
  • [Publications] 高田伸介: Medical Immunology.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: 臨床免疫.

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: "リウマチ学の研究(塩川優一,御〓清允,七川歓次,本間光夫,監修)" 同文書院,

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: "免疫・炎症・膠原病ーその基礎、臨床、治療ー(水島裕 編)" メディカル葵出版,

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: "図説内科診断治療講座 第13巻関節リウマチ、膠原病と類縁疾患(安倍達 編)" メジカルビュー社,

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: "新医科学大系、第8巻B生体の防御機構ーー免疫応答(山村雄一,吉利和 監修)" 中山書店,

    • Related Report
      1988 Annual Research Report
  • [Publications] 坂根剛: "第22回日本医学会総会総会会誌〔I〕(第22回日本医学会総会会誌編集委員会編)" 協和企画通信, (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 星野孝: "第22回日本医学会総会総会会誌〔II〕(第22回日本医学会総会会誌編集委員会編)" 協和企画通信, (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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