| Project/Area Number |
63480197
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
内科学一般
|
|---|
| Research Institution | Okinaka Memorial Institute for Medical Research |
|---|
Principal Investigator |
MURASE Toshio Okinaka Memorial Institute for Medical Research, Senior Investigator, 主任研究員 (60107612)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HARA Mitsuru Okinaka Memorial Institute for Medical Research, Head Investigator, 主任研究員 (60010047)
OKUDO Minoru Okinaka Memorial Institute for Medical Research, Investigator, 研究員
|
|---|
| Project Period (FY) |
1988 – 1990
|
| Project Status |
Completed (Fiscal Year 1990)
|
| Budget Amount *help |
¥6,400,000 (Direct Cost: ¥6,400,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1988: ¥4,000,000 (Direct Cost: ¥4,000,000)
|
|---|
| Keywords | coronary artery sclerosis / Endothelial cells / Cell culture |
|---|
| Research Abstract |
The aim of our study is to establish the culture system of human coronary artery endothelial cells, because the establishment is indispensable for the studies of the pathogenesis of coronary artery sclerosis. We have done many trials on autopsied materials. Since coronary arteries from younger subjects without apparent coronary artery sclerosis were thought to be the appropriate materials for this purpose, we examined several fetus materials as well.
With all our efforts, we have not yet succeeded in the culture of coronary artery endothelial cells. Now we are doing more than we did the culture trials on human materials. We are also doing preliminary studies using porcine coronary arteries.
To our knowledge, there have been no reports showing the successful establishment of human coronary artery endothelial cell culture.
|
