| Project/Area Number |
63480201
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka University |
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Principal Investigator |
HAYASHI Norio Osaka University Medical School Lecturer, 医学部, 講師 (00144478)
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| Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Kazuhiro Osaka University Hospital Staff, 医学部附属病院, 医員
SASAKI Yutaka Osaka University Hospital Staff, 医学部附属病院, 医員
KASAHARA Akinori Osaka University Medical School Assistant, 医学部, 助手 (70214286)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | liver regeneration / signal transduction / PKC / proto-oncogene / DNA合成 / 癌遺伝子 / 肝細胞増殖機構 / 細胞性癌遺伝子 / c-kinase / c-fos / c-myc / c-Ha-ras |
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| Research Abstract |
Liver regeneration provides a good model for studying cell growth and disserentiation. During rat liver regeneration induced by carbon tetrachloride administration, the protein kinase Calpha subspecies was activated in a heterogeneous fashion, a higher number of hepatocytes expressing the protein kinase Calpha subspecies being detected in the pericentral zone than in the periportal zone. This zonal heterogeneity became maximal at 24 h after the treatment. The distribution of hepatocytes expressing the protein kinase C subspecies was roughly coincident with that of hepatocytes exhibiting DNA synthesis. These results suggest that protein kinase C may play a crucial role in liver regeneration.
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