| Project/Area Number |
63480249
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Medical & Dental University |
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Principal Investigator |
SUZUKI Soji Tokyo Medical & Dental University, Faculty of Medicine, Dept. of Radiology, Professor, 医学部, 教授 (80013829)
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| Co-Investigator(Kenkyū-buntansha) |
OOHASHI Isamu Tokyo Medical & Dental University, Faculty of Medicine, Dept. of Radiology, assi, 医学部, 助手 (60213823)
KUWABARA Yuji Tokyo Medical & Dental University, Faculty of Medicine, Dept. of Radiology, lect, 医学部, 助手 (00114752)
SUZUKI Takeo Tokyo Medical & Dental University, Faculty of Medicine, Dept. of Radiology, assi, 医学部, 助手 (60187739)
SATOH Shiro Tokyo Medical & Dental University, Faculty of Medicine, Dept. of Radiology, assi, 医学部, 助手 (70162435)
YOSHIDA Tetsuo Tokyo Medical & Dental University, Faculty of Medicine, Dept. of Radiology, assi, 医学部, 助手 (30134696)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥5,600,000 (Direct Cost: ¥5,600,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1988: ¥4,700,000 (Direct Cost: ¥4,700,000)
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| Keywords | Contrast media / Osmolality / Electromagnetic flowmetery / Laser Dopler flowmetery / Peripheral Angiography / 末梢血行動態 / 下肢閉塞性動脈疾患 / レ-ザ-トップラ-血流計 / 低浸透圧造影剤 / 血管撮影 / レーザー・ドップラー血流計 |
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| Research Abstract |
Experimental study: The effects of lidocaine on the blood flow in the femoral and dorsalis pedis arteries were investigated in eight dogs. The blood flow rate in the femoral artery was significantly elevated by an injection of 0.2, 1.0 or 2.0 mg/kg body weight of lidocaine. The increase in the blood flow rate following the injection of those lidocaine solutions was quite similar in pattern to the injection of contrast media. The time to reach the peak .however, was significantly longer in high osmolality contrast medium than lidocaine solution. It was concluded that the increase of the blood flow following intra-arterial injection of high osmolality contrast media should be reactive hyperemia secondary to momentary ischemia caused by the media.
Clinical study:
The laser Doppler flowmetry on the skin of the lower extremities has been performed during angiography and PTA. The blood flow through the capillaries of the skin was proven to be elevated by intraarterial injection of contrast media (low osmolality contrast media) by the flowmetry. The real-time evaluation of the PTA could be obtained by the laser Doppler flowmeter PeriFlux PF3, Perimed ).
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