| Project/Area Number |
63480251
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
MASAKI Norie Osaka University Medical School Assoc.Prof., 医学部, 助教授 (60028511)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HAYAMI Akimune Osaka University Dental School Assist.Prof., 歯学部, 講師 (30028477)
FUCHIHATA Hajime Osaka University Dental School Professor, 歯学部, 教授 (70028728)
IKEDA Hiroshi Osaka University Medical School Assist.Prof., 医学部, 講師 (10028623)
|
|---|
| Project Period (FY) |
1988 – 1989
|
| Project Status |
Completed (Fiscal Year 1989)
|
| Budget Amount *help |
¥5,300,000 (Direct Cost: ¥5,300,000)
Fiscal Year 1989: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1988: ¥3,600,000 (Direct Cost: ¥3,600,000)
|
|---|
| Keywords | Interstitial radiation therapy / Iriduim-192 / Tongue Cancer / Remote after-loading interstitial irradiation / イリジウムー192 / インジウムー192 |
|---|
| Research Abstract |
Interstitial radiation therapy has played an important role in the management of cancer treatment for head and neck cancer, especially for cancer in the oral cavity. Disadvantages by this conventional interstitial therapy is weighted against the hospitalization of the patients and possible risks due to the radiation exposure to the medical staff. The use of high dose-rate after-loading techniques using Ir-192 has assured this procedure without personal exposure to ionizing radiation during the implantation, and without hospitalization of the patients.
By this remote after-loading technique, the rigid guide needles or applicators (non-radioactive) are introduced first and subsequently inserting the Ir-192 afterloading sources. Several new applicators for use in the oral cavity has been developed. The dose distribution when using these applicators for single plane implant and/or for double plane implants are studied.
Optimum delivery dose by this high dose-rate interstitial therapy should be different from conventional low dose-rate interstitial radiation therapy, with possible dose effect factor 1.5-2.0, although more clinical experience is needed.
|
