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A study of elucidating brain mechanisms involved in successful psychologicalintervention for schizophrenics : Attempts of P300-amplitude manipulation overcoming schizophrenic deficits in cognition and learning.

Research Project

Project/Area Number 63480257
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionUniversity of Tokyo

Principal Investigator

NIWA Shin-ichi  Univ. of Tokyo, Faculty of Medicine, Lecturer., 医学部(病), 助手 (30110703)

Co-Investigator(Kenkyū-buntansha) FUKUDA Masato  Univ. of Tokyo, Faculty of Medicine, Lecturer, 医学部(病), 助手
HIRAMATSU Ken-ichi  Univ. of Tokyo, Faculty of Medicine, Lecturer, 医学部(病), 助手 (50218814)
ITOH Kenji  Univ. of Tokyo, Faculty of Medicine, Lecturer, 医学部, 助手 (80010106)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥2,600,000 (Direct Cost: ¥2,600,000)
Keywordsschizophrenia / event-related potential / P300 / learning / cognitive therapy / behavioral therapy / task strategy / brain function / coaching
Research Abstract

Employing the P300 component of ERPs as an electrophysiological index, brain mechanisms involved in successful psychological interventions in schizophrenia were investigated with particular reference to whether their effectiveness of improving schizophrenic cognitive-behavioral deficits is measured through the extent to which P300 amplitudes are augmented.
For this purpose, variations in P300-amplitudes due to psychological manipulating procedures were monitored in a three tone discrimination task which consists of tones at 950.1000, and 1053 Hz in a random sequence with a priori probability of 1/6, 4/6. and 1/6. respectively. In the task, subjects were requested to press a lever upon detection of one of two kinds of infrequent tones.
<< Experiment 1 : P300 to frequent tones ( "frequent P300" )>> Schizophrenic subjects, who are known to fail in demonstrating frequent P300s in contrast to healthy controls, were instructed to perform the task in the following three ways in three different … More occasions. These instructions were aimed at facilitating to alter schizophrenics' task-performing strategies into those that healthy controls are speculated to employ. During the task, variations in P300s produced after the instructions were observed.
(1) Via verbal instruction: most schizophrenic subjects showed no P300 change, except one subject who, while performing the task, became aware of the effective strategy by herself that healthy subjects employed. This subject showed a significant P300-amplitude increase after her awareness of the strategy. (2) Via response-mediated training; a significant reduction of P300 was observed. (3) Via target-intensity augmenting method; no significant change was observed.
<<Experiment 2 : P300 to target tones>> To facilitate patients' effectiveness in target detection, a psychological intervention was attempted through delivering a buzzer sound after each designated target tone that informed the just prior tone was the target tone ( "coaching method" ). The smaller P300 group, which showed smaller P300 amplitudes before the coaching method, demonstrated a significant increase in P300 amplitude, whereas the larger P300 group displayed a significant decrease. The smaller P300 group also showed an improvement in the performance level. As for P300 amplitudes to infrequent non-target tones, the smaller P300 group showed no change in the amplitudes: while, the larger P300 group displayed a significant decrease.
The results of Experiment I seem well correlated with our clinical experience in schizophrenic patients: (1) any psychological strategy works most effectively only when noticed by patients; (2) no improvement in task- performance level is obtained through a short-time practice; (3) any intervention not meeting patients rather results in patients' confusion. The results of Experiment 2 indicate the followings: (1) P300 amplitudes in schizophrenics can be altered by psychological intervention to some extent; (2) the direction of P300 amplitude changes are different among patients depending upon their original P300 amplitudes, with the changes being considered specific effects of the intervention; (3) hence, P300 seems a useful index for determination of indication and assessment of efficacy of psychotherapy, behavioral therapy, and cognitive therapy. Less

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (25 results)

All Other

All Publications (25 results)

  • [Publications] 福田正人 他: "精神分裂病患者における学習過程とP300成分-frequent P300成分出現におよぼす方略教示の影響" 精神医学. 30. 877-883 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 福田正人 他: "特集:分裂病治療のための機能評価、脳の生理・生化学的機能評価" 臨床精神医学. 18. 157-165 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 平松謙一: "精神分裂病をめぐるトピックス-分裂病の認知障害" CLINICAL NEUROSCINENCE. 6. 76-78 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masato Fukuda et al.: "Psychological intervention can partly alter P300 amplitude abnormalities in schizophrenics" Japanese Journal of Psychiatry and Neurology(in press). 43. (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 伊藤憲治: "脳波のスペクトル解析" 生体時系列信号とゆらぎ研究会研究報告集. 2. 53-54 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 斎藤治 他: "文脈処理とP300" 「生体環境の時系列情報解析研究会」研究報告集. 1. 52-55 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 丹羽真一: "『分裂病の精神病理と治療1』「方略変容と事象関連電位」" 星和書店, 293-314 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fukuda M, Niwa S-I, Hiramatsu K-I, Saitoh O: "Therapeutic implications of brain function assessments in schizophrenia." Japanese Journal of Clinical Psychiatry 18:157-165, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fukuda M, Nagakubo S, Nakagome K, Saitoh O, Hiramatsu K-I, Niwa S-I, Hayashida S, Kameyama T, Itoh K: "Possible influential effects of verbal instructions on P300sduring three-tone discrimination tasks in schizophrenics." Clinical Psychiatry 30:877-883, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fukuda M, Niwa S-I, Hiramatsu K-I, Saitoh O, Kameyama T, Nakagome K, Iwanami A, Nagakubo S: "An attempt to improve performance levels in schzophrenics through response-mediated manipulation of task-strategy : its outcome and effects on P300s." Japanese Journal of Psychiatry and Neurology 42:689, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fukuda M, Niwa S-I, Hiramatsu K-I, Hayashida S, Saitoh O, Kameyama T, Nakagome K, Iwanami A, Sasaki T, Itoh K: "Interventive efforts and intra-individual variations of P300 amplitudes in schizophrenics." Ann Bull RILP 23:153-161, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fukuda M, Niwa S-I, Hiramatsu K-I, Hayashida S, Saitoh O, Kameyama T, Nakagome K, Iwanami A, Sasaki T, Itoh K: "Psychological intervention can partly alter P300 amplitude abnormalities in schizophrenics." Japanese Journal of Psychiatry and Neurology 43:in press, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masato Fukuda et al.: "Psychological intervention can partly alter P300 amplitude abnormalities in schizophrenics." Japanese Journal of Psychiatry and Neurogy. 43. inpres (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 伊藤憲治 他: "脳波のスペクトル解析" 生体時系列信号とゆらぎ研究会研究報告集. 2. 53-54 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masato Fukuda et al.: "Interventive efforts and intra-irdividual variations of P300 amplitude in schizophrenics" Ann Bull RILP. 23. 153-161 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 林田征起 他: "健常者のNd,P300の標準化の試み(第2報):シラブル弁別課題とオドボ-ル課題のP300の比較" 脳波と筋電図. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 斉藤治 他: "文脈処理とP300" 「生体環境の時系列情報解析研究会」研究報告集. 1. 52-55 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 岩波明 他: "文脈効果とP300" 脳波と筋電図.

    • Related Report
      1989 Annual Research Report
  • [Publications] 福田正人: 精神医学. 30. 877-883 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Fukuda,M.: The Japanese Journal of Psychiatry and Neurology. 42. 689-689 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 福田正人: 臨床精神医学. 18. 157-165 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 平松謙一: CLINICAL NEUROSCIENCE. 6. 76-78 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 福田正人: CLINICAL NEUROSCIENCE. 6. 40-44 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 福田正人: 臨床精神医学. 17. 925-934 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 丹羽真一: "分裂病の精神病理と治療1(タイトル 方略変容と事象関連電位)" 星和書店, 293-314 (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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