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Analysis on the developmental defects of intra-pelvic muscles and their nerve supplies, in the pig model of ano-rectal malformations.

Research Project

Project/Area Number 63480287
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

SAWAGUCHI Shigenori  Vice President of University of Tsukuba, 副学長 (90111385)

Co-Investigator(Kenkyū-buntansha) YAGAMI Ken-ichi  Institute of Fundamental Med. Associate Prof., 臨床医学系, 助教授 (40166476)
OCHI Gohei  Institute of Clinical Med. Assistant Professor, 臨床医学系, 講師 (20185614)
OHKAWA Haruo  Institute of Clinical Med. Associate Professor, 臨床医学系, 助教授 (30009667)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥5,400,000 (Direct Cost: ¥5,400,000)
Fiscal Year 1989: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1988: ¥3,400,000 (Direct Cost: ¥3,400,000)
Keywordsano-rectal malformations / anal atresia / intra-pelvic peripheral nerve supply / intra-pelvic autosomal nerve / pelvic muscles / bowel control / internal anal sphincter / pig model of anorectal malformations / 外肛門括約筋 / 顕微画像の三次元立体構築 / 会陰神経 / 横隔膜ヘルニア
Research Abstract

1) Due to the results of our own establishment of pig model of ano-rectal malformations, we are capable to obtain freely pig material with the anomalies. The maintenance itself of two pig families with ano-rectal malformations is one of the greatest results of this study.
2) Using the materials, fundamental studies for the improvement of post-operative bowel motion was scheduled, because the post-operative functional results of high type anorectal malformations were not necessarily good up to the present.
3) The propriety of the pig model for simulation of human disease was studied in the first place. Using young adult pig with weight of 30kg, the pelvic organs were dissected to clarify all the routes of sacral plexus and pudendal plexus down to the very peripheries, with intrapelvic muscle dissections. The similarities and differences were studied according to the textbooks of human anatomy. Muscles and plexi were all similar to human, except the absence of the pubo-rectal muscle sling … More in the adult pig. The adequacy of the pig material as model study material was confirmed.
4) l Studies on the morphology of pudendal plexus and nerve supply to intrapelvic muscles: Eight sides including 2 male and female normal pig and 2 male and femalk pigs with ano-rectal malformations were studied. All the details of nerve route were clarified by the classical dissection technique. Most of the material were adult, but partly neonatal materials were used for supplement of the adult material in the recent stage. In the anomalous pig, the external sphincter was very scanty or lacking. There was no nerve supply to the external sphincter in the case without this muscle.
Otherwise all the nerve supplies were quite normal.
5) Studies on the intrapelvic autosomal nerve supply: Six sides, including one normal male and female, and two anomalous male and female materials were studied. There were no abnormalities in the ano-rectal malformations. According to the size of the materials, the autosomal nerves was observed to grow in size and volume. The factor of growth of the nerve system is one of the next study purpose. Less

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (27 results)

All Other

All Publications (27 results)

  • [Publications] 松本正智: "疾患モデルとしてのブタの家族性横隔膜ヘルニアの検討" 医学のあゆみ. 148. 371-372 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大川治夫: "ブタ鎖肛における内肛門括約筋の発生学的検討" 日本小児外科学会雑誌. 25. 530 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 松本正智: "鎖肛ブタにおける骨盤内神経分布の検討,〜第1報〜陰部神経叢について" 日本小児外科学会雑誌. 25. 530 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 松本正智: "鎖肛ブタにおける骨盤内自律神経系の検討" 日本小児外科学会雑誌(in press). 26. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大川治夫: "ブタ鎖肛における病型の性差に関する発生学的検討" 日本小児外科学会雑誌(in press). 26. (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大川治夫: "鎖肛ブタモデルの確立とその発生学への応用" 小児外科(in press). 22(6). (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sakaniwa,M.: "Computrized onalysis of anorectal manometry 24" Springer Verlog(Berlin), 11 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Matsumoto, H. Ohkawa, K. Ueoka, G. Ochi, M. Kaneko and S. Sawaguchi: "Studies on familial congenital diaphragmatic hernia in pigs." J. of Clinical and Experimental Medicine 148;371-372, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Ohkawa: "Studies on ano-rectal malformations, using animal model (pig)." J. of Clinical and Experimental Medicine 145:493, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Matsumoto, H. Ohkawa, K. Ikebukuro and S. Sawaguchi: "Studies on the intra-pelvic nerve supplies. (I)On pudendal plexus." J. Jap. Society of Pied-A-Terre. Surg. 25:530, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Ohkawa, K. Ikebukuro, M. Matsumoto, G. Ochi, M. Kaneko, M. Sakaniwa, S. Sawaguchi and SCJ Van der Putte: "Embryological studies on the anal internal sphincter." J. Jap. Saucy. of Pediatric Surgeons. 25:530, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Matsumoto, H. Ohkawa, M. Sakaniwa, M. Kaneko, G. Ochi, T. Hori, K. Ikebukuro and T. Amagai: "Studies on the intra-pelvic autosomal nerve supplies in pig with ano-rectal malformations." J. Jap. Saucy. of Pied-A-Terre. Surgeons 26:1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] H. Ohkawa, M. Matsumoto, K. Ikebukuro, T. Hori, M. Kaneko and S. Sawaguchi: "Establishment of pig animal model of ano-rectal malformations and their application for embryological studies." Jap. J. of Pied-A-Terre. Surg.:22(6);1990.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M. Sakaniwa, S. Sawaguchi, H. Ohkawa and K. Ikebukuro: "Computerized analysis of anorectal manometer." Progress in Pediatric Surgery vol.24:21-32,1989 (Berlin).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 松本正智: "疾患モデルとしてのブタの家族性横隔膜ヘルニアの検討" 医学のあゆみ. 148. 371-372 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川治夫: "動物(ブタ)モデルを用いた鎖肛の研究" 医学のあゆみ. 145. 493 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松本正智: "鎖肛ブタにおける骨盤内神経分布の検討第1報〜陰部神経叢について" 日本小児外科学会雑誌. 25. 530 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川治夫: "ブタ鎖肛における内肛門括約筋の発生学的検討" 日本小児外科学会雑誌. 25. 530 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 松本正智: "鎖肛ブタにおける骨盤内自律神経系の検討" 日本小児外科学会雑誌. 26. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川治夫: "鎖肛ブタモデルの確立とその発生学への応用" 小児外科. 22(6). (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sakaniwa,M: "Progress in Pediatric Surgery 24(Computiged analysis of anorecfal manowetry)" Springer Velag(Berlin), 11 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川治夫: 医学のあゆみ. 145. 493- (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大川治夫: 日本小児外科学会雑誌. 24. 424- (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松本正智: 医学のあゆみ. 148. 371-372 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大川治夫: 日本小児外科学会雑誌. 25. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 松本正智: 日本小児外科学会雑誌. 25. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] H.OHKAWA: Congenital Anomalies. 28. (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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