| Project/Area Number |
63480306
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Shimane Medical University (1990)
Nagasaki University (1988-1989) |
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Principal Investigator |
TSUCHIYA Ryoichi Shimane Med. Univ., 副学長 (70025534)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIURA Kiyoaki Nagasaki Univ., 医学部附属病院, 医員
TOKUNAGA Shigeki Nagasaki Univ., 医学部附属病院, 医員
MAEDA Harunobu Nagasaki Univ., 医学部, 講師 (10211559)
IZAWA Kunihide Nagasaki Univ., 医学部附属病院, 助教授 (40124820)
TSUNODA Tsukasa Nagasaki Univ., 医学部, 助教授 (00110841)
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1988: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | Acute pancreatitis / Chronic pancreatitis / Experimental pancreatitis / Deoxycholic acid / 自家胆汁 / デオキシコール酸 |
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| Research Abstract |
The purpose of this study is to clarify whether chronic pancreatitis may follow acute pancreatitis or not. Acute pancreatitis was induced in dogs by the intraductal injections of 10% deoxycholic acid (DCA) through a silicone tube, which had been inserted from the tail of the pancreas. The dogs were divided into 4 groups.
Groupe 1 : 4 dogs with acute edematous pancreatitis induced by a single injection of DCA
Group 2 (1) : 5 dogs with acute edematous pancreatitis by low pressure injection of DCA 4 times at 1 week interval
Group 2 (2) : 3 dogs with acute hemorrhagic pancreatitis by high pressure injections of DCA 4 times at 1 week interval
Control group : 4 dogs with saline injection 4 times at 1 week interval In each dog, caelurein-secretin test and intravenous glucose tolerance test were done at the discretion of time. After completion of the experiment, the dogs were killed and pathological studies were performed.
There were no significant changes of the results of caelurein-secretin test and intravenous glucose tolerance test between any groups. With regard to pathological lesions, inter- and intralobular collagen fibers in the pancreatic tissue in group 1 were increased 1 week after the injection, but 3 weeks after the injection the inter- and intralobular collagen fibers were decreased. In group 2 (1), the similar pathological changes to group 1 were seen but the changes were still observed 8 weeks after the injections. In group 2 (2), a marked increase of inter- and intralobular collagen fibers and replacement of pancreatic lobes by fibrosis were observed even in the 16th week after the injections.
In conclusion, it is suggested that acute pancreatitis induced by repeated intraductal injection of DCA could result in chronic pancreatitis.
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