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Transplantation of Cultured Schwann Cell

Research Project

Project/Area Number 63480343
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionHiroshima University

Principal Investigator

MIYAMOTO Yoshihiro  Hiroshima Univ., School of Medicine, Associate Professor, 医学部, 助教授 (00098625)

Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1990: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1989: ¥1,200,000 (Direct Cost: ¥1,200,000)
Fiscal Year 1988: ¥3,800,000 (Direct Cost: ¥3,800,000)
KeywordsSchwann cell / Sciatic nerve / Regeneration / ラミニン / 脊髄後根神経節 / Neurite Outgrouth / 線維芽細胞 / Schwann細胞 / Laminin
Research Abstract

We performed the experimental study for transplantation of cultured schwann cell. The appropriate time of transplantation is within two weeks because of the contamination by fibroblasts. We bridged 15mm gap in rat sciatic nerves by silicone tube and filled with agar, fibrin and collagen gel. No significant findings of nerve regeneration were found. Next, we added Epidermal Growth factor and Somotomedin to each materials. There were no significant findings on the regeneration of rat sciatic nerves. Then we filled with the gel containing Laminne. Four weeks later, we found soft tissues in the silicone tube and impart schwann cells under magnetic field. We added schwann cells to the gel and filled in the silicone tube. However, no significant findings were found between filling with gel only and adding schwann cells. Those reasons were suspected that the gel disappeared, schwann cell degeneerated and the gel itself inhibited for nerve regeneration.
In future, we would like to develop the technique to fill cultured schwann cells in silicone tube and to prevent cultured schwann cells from degeneration.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 茂木 定之: "脊髄後根神経節を利用したSchwann細胞の培養" 日本形成外科学会誌. 9. 730 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y. Miyamoto: "Morphological Reaction of Cellular Elements and the Endoneurium Following Nerve Section" Peripheral Nerve Repair and Regeneration. Vol. 3. 7-18 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 茂木 定之: "脊髄後根神経節を利用したSchwann細胞の培養" 日本形成外科学会誌. 9. 730 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 茂木定之: "脊髄後根神経節を利用したSchwann細胞の培養" 日本形成外科学会誌. 9. 730 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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