| Project/Area Number |
63480345
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SUZUKAWA Masayuki M. D. Lecturer, Dept. of Emergency Medicine University of Tokyo, 医学部・附属病院, 講師 (00162917)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Yoshitugu M. D. Assistant Professor, Dept. of Anesthesiology University of Tokyo, 医学部・附属病院, 助手 (30166748)
NUMATA Katsuo M. D. Professor, Dept. of Anesthesiology University of Tokyo, 医学部・附属病院, 教授 (40048947)
川原 信隆 東京大学, 医学部(病), 医員
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥6,600,000 (Direct Cost: ¥6,600,000)
Fiscal Year 1990: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1989: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 1988: ¥4,400,000 (Direct Cost: ¥4,400,000)
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| Keywords | Pulmonary Carillary Pressure / Intact Lung / Pulmonary Edema / Arterial Occlusion Method / Intact lung |
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| Research Abstract |
Pulmonary capillary pressure (Pc), one of the important factors for lung water transport, is difficult to measure in clinical settings. We 1) investigated on the pulmonary artery occlusion method to measure Pc in intact lung of experimental animals and 2) developed clinically applicable system to measure Pc.
1) We developed an ECG-triggered pulmonary artery occluder which can occlude an artery instantaneously (within 20 msec) at an arbitrary phase in a cardiac cycle. With this occluder we occluded externally a pulmonary artery of an experimental animal and measured pressure decay curve by a Millar catheter tip transducer. An electrically analogous model of pulmonary circulation was analyzed mathematically and real decay curve was fit to ideal curve and Pc was calculated. We found that there was a phasic variation of Pc in a cardiac cycle. Serotonin and histamine was injected and changes in Pc and artery/venous resistances were calculated and usefulness of our method was confirmed. Then we measured Pc and other pulmonary circulation parameters in oleic acid induced pulmonary edema and also investigated the effect of TxA2 on pulmonary circulation.
2) We developed an internal occlusion device which inflate a balloon of a pulmonary artery catheter rapidly, and with this device decay curve was obtained and compared with external occlusion. We found that it was possible to measure Pc in closed chest animals. However, rapid inflation of a balloon may be harmful in clinical settings and we developed a double pulmonary artery port catheter which measures pressures distal and proximal to the balloon simultaneously. With this fluid-filled catheter we had to change the calculation method of Pc because of poor frequency response but we concluded that it was possible to decide Pc with a little difference from our previous method. Clinical investigation is now being performed.
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