| Project/Area Number |
63480360
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Department of Urology, Chiba University, School of Medicine. |
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Principal Investigator |
NAKADA Teruhiro Chiba Univ.Dept.Urol.Assoc.Prof., 医学部, 助教授 (50009495)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMAZAKI Jun Chiba Univ. Dept.Urol. Prof., 医学部, 教授 (10008229)
片山 喬 富山医科薬科大学, 医学部, 教授 (10009441)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,700,000 (Direct Cost: ¥2,700,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1988: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Keywords | hypothalamus / norepinephrine / non-collagen protein / collagen / renal artery stenosis / hypertension / ノルエピネフリン / 腎動脈狭窄 / 高血圧 / 腎性高血圧症 / non-collagen protein / central norepinephrine / 腎動脈狭突 |
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| Research Abstract |
Two series of experiments were conducted whether the central catecholamine would participate in the elevation of blood pressure in 2-kidney, one clip (2K-1C)Goldblatt hypertensive rats. The effect of 6-OHDA injected intraventricularly before the induction of hypertension or after the establishment of hypertension was examined. The hypothalamic norepinephrine content of 2K-1C rats in acute phase is 50% lower (p 0.05) than that of sham rats, but norepicontent in pons is similar in these animals. The content of dopamine in hypothalamus,or pons is similar in 2K-1C rats and normotensive rats in acute phase.
The content of these monoamines either in hypothalamus or pons in 2K-1C rats in chronic phase is identical with that in sham rats. These findings suggest that hypothalamic norepinephrine participates in the development of hypertension in 2K-1C rats in the acute phase. Rats had been intraventricular injection of 6-OHDA before clipping the unilateral renal artery that caused selective ablation of the central noradrenergic neurons. Central catecholamines and the in vivo incorporation of 3H-proline into vascular non-collagen protein were determined in 2K-1C rats in the acute hypertensive stage and results were increased incorporation into the protein fraction. It is suggested that increased non-collagen protein synthesis in the mesenteric artery and the low level of hypothalamic norepinephrine concentration partidipates in the development of 2K-1C hypertension.
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