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Efiology and Treatment of Recurrent Ofitics Media

Research Project

Project/Area Number 63480382
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Otorhinolaryngology
Research InstitutionOita Medical University

Principal Investigator

MOGI Goro  Oita Medical University, Dept. of Otolaryngology, Professor, 医学部, 教授 (20035190)

Co-Investigator(Kenkyū-buntansha) KAWAUCHI Hideyuki  Oita Medical University, Dept. of Otolaryngology, Assistant Professor, 医学部, 講師 (50161279)
友永 和宏  大分医科大学, 医学部, 助手 (90188805)
黒野 祐一  大分医科大学, 医学部, 助手 (80153427)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1991)
Budget Amount *help
¥6,300,000 (Direct Cost: ¥6,300,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1988: ¥3,700,000 (Direct Cost: ¥3,700,000)
KeywordsRecurrent otitis media / Otitis media with effusion / Immunology of the middle ear / Mucosal immunity of the ear / Oral vaccination / 細菌性中耳炎 / 粘膜免疫賦活 / 経口ワクチン療法 / 腸溶カプセル / 抗原特異的IgA抗体 / 耳管機能障害 / I型アレルギ- / 感染抵抗性 / 細菌の定着性
Research Abstract

Otitis media is one of the most common diseases among upper respiratory tracts infections. Acute otitis media(AOM) and otitis media with effusion(OME) are a self limited disorder, but some cases recurrs repeatedly. We investigated causes of AOM and OME and these recurrence factors ; and the prevention in particular of immunologic and allergologic approach.
1. An animal model study using Japanese monkey and three-dimensional images-analysis revealed that inflammation that occurs in the tympanic cavity rapidly spreads all over the mastoid air cells, producing inflammatory fluid and that inflammatory changes at the tympanic isthmus and eustachian tube block the clearance of fluid.
2. it was found that middle ear effusion itself induces new effusion. Therefore, removal of the effusion in essential for the treatment of OME.
3. The type I allergy is not an etiologic factor. However, allergic of the nose caused tubal dysfunction. An animal study clearly demonstrated that allergic reactions of the nose disturb the clearance of effusion.
4. Investigation on the immune response of the middle ear showed that the systemic immunity (circulating antibodies) is a causative factor for OME because of the formation of immunocomplex, while the mucosal immunity acts as anti-inflammatory agent. Secretory IgA antibody activity against S. pneumoniae and H. influenza blocked the attachment of these bacteria to the mucosal membrane.
5. Oral immunization induced antigen specific T suppressor cells that suppress the occurrence of immune-mediated otitis media.
6. It was demonstrated by an experimental study that oral vaccine therapy with S. pneumoniae elicits mucosal IgA responses to prevent pneumococcal otitis media. Results suggested the possibility of clinical application of oral vaccination by enteric capsules for the prevention of middle ear infection.

Report

(4 results)
  • 1991 Final Research Report Summary
  • 1990 Annual Research Report
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (41 results)

All Other

All Publications (41 results)

  • [Publications] Noritake Watanabe,MD: "Induction of Antigien-Specific IgA-Forming Cells in the Middle Ear Mucosa" Archives of Otolaryngology-Head&Neck Surgery. 114. 758-762 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shigehiro Ueyama,MD: "Suppression of Immune-Mediated Otitis Media by T-Suppressor Cells" Archives of Otolaryngology-Head&Neck Surgery. 114. 878-882 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Goro Mogi,MD: "Influence of Nasal Allergic Reactions on the Clearance of Middle Ear Effusion" Archives of Otolaryngology-Head&Neck Surgery. 116. 331-334 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tatsuya Fujiyoshi,MD: "Three-Dimensional Images of the Temporal Bone and Experimental Otitis Media in Japanese Monkeys" Archives of Otolaryngology-Head&Neck Surgery. 116. 813-819 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichiro Shimamura,MD: "The Role of Bacterial Adherence in Otitis Media with Effusion" Archives of Otolaryngology-Head&Neck Surgery. 116. 1143-1146 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroyuki Yoshimura,MD: "Oral vaccine Therapy for Pneumococcal Otitis Media in Animal Model" Archives of Otolaryngology-Head&Neck Surgery. 117. 889-894 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Goro Mogi,MD: "Secretory IgA and Bacterial Attachment to the Nasopharyngeal Mucosal Cells in the Chronic Secretory Otitis Media" Kugler Publications, 6 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Goro Mogi,MD: "Mucosal Immunity of the Middle Ear and Uppre Respiratory Tract" Kugler Publications, (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Noritake Watanabe: "Induction of Antigen-Specific IgA-Forming Cells in the Middle Ear Mucosa." Archves of Otolaryngology - Head & Neck Surgery. 114. 758-762 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Shigehiro Ueyama: "Suppression of Immune-Mediated Otitis Media by T-Suppressor Cells." Archives of Otolaryngology - Head & Neck Surgery. 114. 878-882 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Goro Mogi: "Influence of Nasal Allergic Reactions on the Clearance of Middle Ear Effusion." Archives of Otolaryngology - Head & Neck Surgery. 116. 331-334 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Tatsuya Fujiyoshi: "Three-Dimensional Images of the Temporal Bone and Experimental Otitis Media in Japanese Monkeys." Archives of Otolaryngology - Head & Neck Surgery. 116. 813-819 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Koichiro Shimamura: "The Role of Bacterial Adherence in Otitis Media with Effusion." Archives of Otolaryngology - Head & Neck Surgery. 116. 1143-1146 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroyuki Yoshimura: "Oral Vaccine Therapy for Pneumococcal Otitis Media in Animal Model." Archives of Otolaryngology - Head & Neck Surgery. 117. 889-894 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Goro Mogi: Kugler Publications. Secretory IgA and Bacterial Attachment to the nasopharyngeal Mucosal Cells in the Chronic Secretory Otitis Media., (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Goro Mogi: Kugler Publications. Mucosal Immunity of the Middle Ear and Upper Respiratory Tract.,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1991 Final Research Report Summary
  • [Publications] Hiroyuki Yoshimura: "Oral Vaccine Therapy for Pneumococcal Otitis Media in Animal Model" Archives of Otolaryngology,Head & Neck Surgery. in press.

    • Related Report
      1990 Annual Research Report
  • [Publications] Koichiro Shimamura: "The Role of Bacterial Adherence in Otitis Media with Effusion" Archives of Otolaryngology,Head & Neck Surgery. 116. 1143-1146 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Goro Mogi: "Influence of Nasal Allergic Reactions on the Clearance of Middle Ear Effusion" Archives of Otolaryngology,Head & Neck Surgery. 116. 331-334 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Issei Ichimiya: "Analysis of Immunocompetent Cells in the Middle Ear Mucosa" Archives of Otolaryngology,Head & Neck Surgery. 116. 324-330 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yuichi Kurono: "Inhibition of Bacterial Adherence and Nasapharyngeal Secretions" Annals of Otology,Rhinology and Laryngology.

    • Related Report
      1990 Annual Research Report
  • [Publications] Tetsuo Watanabe: "Distribution of Mast Cells in the Tubotympanic of Guinea Pigs" Annals of Otology,Rhinology and Laryngology.

    • Related Report
      1990 Annual Research Report
  • [Publications] Junko Nakata: "Pathogenesis of Otitis Media with EffusionーComparison of Pathologic Findings of Experimental Otitis Media with Effusion Induced by Various Proceduresー" Laryngoscope.

    • Related Report
      1990 Annual Research Report
  • [Publications] Kazuhiro Tomonaga: "Type I Allergic Reactions of the Middle Ear and Eustachian TubeーAn Experimental Studyー" Auris Nasus Larynx. 17. 121-131 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 茂木 五郎: "中耳炎と免疫ー滲出性中耳炎の成因と経口ワクチンによる予防へのアプロ-チ" 大分医科大学耳鼻咽喉科学教室 茂木五郎, 169 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] Goro Mogi,Hideyuki Kawauchi,Yuichi Kurono: "Development of the immune system in children" Rhinology. 24. 15-24 (1986)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kazuhiro Tomonaga,Tokuo Chaen,Goro Mogi: "Type I allergic reactions of the middle ear and eustachian tube -An experimental study-" Auris Nasus Larynx.

    • Related Report
      1989 Annual Research Report
  • [Publications] Kazuhiro Tomonaga,Yuichi Kurono,Goro Mogi: "The role of nasal allergy in otitis media with effusion" Acta Otolaryngol(Stock). 458. 41-47 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Goro Mogi,Tokuo Chaen,Kazuhiro Tomonaga: "Influence of nasal allergic reactions on the clearance of middle ear effusion" Archives of Otolaryngology.

    • Related Report
      1989 Annual Research Report
  • [Publications] 金田規嗣,川内秀之,植山茂宏,茂木五郎: "中耳細菌感染における食細胞機能の役割:放射線照射モルモットを用いた実験的検討" 日本耳鼻咽喉科免疫アレルギ-研究会誌. 7(2). 60-61 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 川内秀之,金田規嗣,茂木五郎: "中耳感染における食細胞機能の役割" 日本耳鼻咽喉科感染症研究会会誌. 8(1). 1-5 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 茂木五郎: "中耳炎と免疫ー滲出性中耳炎の成因と経口ワクチンによる予防へのアプロ-チ" 169 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 茂木五郎,友永和宏: "滲出性中耳炎とアレルギ-・耳鼻咽喉科頭頚部外科MOOK No.11 滲出性中耳炎・野村恭也,本庄巖編" 金原出版, 7 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Masashi Suzuki;Hideyuki Kawauchi;Goro Mogi: American Journal of Otolaryngology. 9. 199-209 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shigehiro Ueyama;Hideyuki Kawauchi;Goro Mogi: Archives of Otolaryngology. 114. 878-882 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yuichi Kurono;Tatsuya Fujiyoshi;Goro Mogi: Annals of Otology,Rhinology,and Laryngology.

    • Related Report
      1988 Annual Research Report
  • [Publications] Yuichi Kurono;Goro Mogi: Acta Otolaryngol(Stockn). Suppl454. 214-217 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Noritake Watanabe;Hiroyuki Yoshimura;Goro Mogi: Archives of Otolaryngology. 114. 758-762 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Issei Ichimiya;Shigehiro Ueyama;Goro Mogi: Acta Otolaryngol.

    • Related Report
      1988 Annual Research Report
  • [Publications] Goro Mogi: "EXPERIMENTAL OTITIS MEDIA WITH EFFUSION WithEmphasis on Mucosal Immunity(In:Immunobiology,Histophysiology,Tumor Immunology in Otorhinolaryngology)" Kugler publications, 253-263 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] Goro Mogi;Joel M.Bernstein: "Immune Mechanisms in Otitis Media with Effusion(In:Immunology of the Ear)" Raven Press, 279-299 (1987)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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