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The Explication of Onset Mechanism in Ham.

Research Project

Project/Area Number 63480480
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Laboratory medicine
Research Institution国立予防衛生研究所

Principal Investigator

YOSHIHARA Namiko  National, Institute of Health, Alds Research Center, Director, エイズ研究センター, 室長 (80010255)

Co-Investigator(Kenkyū-buntansha) HASEGAWA Ayako  Nationalinstitute of Health, Dept. of Central Diagnostic Laboratory, Chief Recea, ウイルス中央検査部, 主任研究員 (10132896)
AKATSUKA Toshitaka  National Institute of Health, Dept. of Etero Virus, Chief Recearcher., 腸内ウイルス部, 主任研究員 (30159321)
SHOJI Hisako  National Institute of Health, Dept. of Blood Products, Recearcher., 血液製剤部, 研究員
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥6,200,000 (Direct Cost: ¥6,200,000)
Fiscal Year 1990: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1989: ¥1,700,000 (Direct Cost: ¥1,700,000)
Fiscal Year 1988: ¥3,800,000 (Direct Cost: ¥3,800,000)
KeywordsCD4 / CD8 / HAM / HIV / HTLV-1 / C型ウイルス粒子 / Mycoplasma / モノクロ-ナル抗体 / CD4 / CD8 / HIV-1 / HTLV-1 / 細胞表面抗原 / HTLV-I / 細胞変性効果 / 間接蛍光抗体法
Research Abstract

This studies have attempted Human Immunodeficiency Virus (HIV) infection in four CD4^+ or CD8^+ T-cell lines derived from HTLV-1 associated myelopathy virus (HAM) patients.
Not only CD4^+ cell line but also CD8^+ cell line could be infected with HIV and CD4^+ cell line showed a higher susceptibility than CD8^+ cell line on HIV infection.
HIV antigen in early stage after HIV incoulation was detected by using enzymed linked immunoabsorbent assay (ELISA) rather than indirect Immunofluorescence Assay (IFA).
HTLV-1 producing CD4^+ and CD8^+ cell lines became to express two viral antigens (HTLV-1 and HIV) after HIV inoculation.
The results indicated that CD4^-CD8^+ T-cell line from patient with HAM can be infected with HIV. So that, we have found that other epitopes except for CD4 antigen may be associated with HIV infection.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (1 results)

All Other

All Publications (1 results)

  • [Publications] 東海林 寿子,中永 和枝,吉原 なみ子: "CD4陰性CD8陽性HAM由来株におけるHIV感染に対する感受性の検討" 臨床病理. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary

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Published: 1988-04-01   Modified: 2016-04-21  

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