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A relation between novel blood group antigens of porcine erythrocytes and meat property.

Research Project

Project/Area Number 63490003
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionHokkaido University of Education

Principal Investigator

SAKO Fumiyo  Hokkaido University of Education, Faculty of Education, Sapporo Campus, Assistant Professor, 教育学部札幌分校, 助教授 (50002481)

Co-Investigator(Kenkyū-buntansha) MAKITA Akira  Hokkaido University, School of Medicine, Professor, 医学部, 教授 (60004561)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,900,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1988: ¥2,900,000 (Direct Cost: ¥2,900,000)
KeywordsPig stress syndrome / Porcine erythrocyte / Porcine plasma / Blood group glycolipids / A-antigen / H-antigen / ブタ赤血球膜 / O(H)型抗原
Research Abstract

Chemical characterization of epitopes in human blood group ABH substances have been carried out mostly on human ovarian cyst mucin as well as porcine gastric mucin.
Porcine blood group antigenicity is grouped into more than ten systems, each of which is classified into plural subtypes based on serological reactivity. They include the antigenicities similar to human type-A and -H. However, the blood group substances have not been characterized in porcine erythrocytes.
We have purified two minor glycosphingolipids with human blood group A and H antigenicity from porcine erythrocyte membranes which were obtained from the pooled blood. Through several methods the porcine erythrocyte antigens were found to belong to lactoseries (type 1 chain); IV^2Fucalpha, IV^3GalNAcalpha Lc_4 Cer for the type A and IV^2FucalphaLc_4Cer for the type H, in contrast to the antigenic glycolipids in human erythrocytes mostly belonging to neolactoseries (type 2 chain). It has been known that in pigs with human type-A or -H blood group, the antigenicity is detected in digestive secretions and serum but not on red blood cells at birth.
The A and H antigenicity on the red cells can be detected during the first month of life. Similarly to Lewis antigens in man, acquisition of the A antigenicity onto porcine red cells from plasma has been demonstrated. Then we have examined whether the A and H glycolipids found in porcine erythrocytes are present in serum, and identified the two antigenic glycolipids therein.
Therefore, out results will support that the porcine A and H glycolipids are transferred from plasma to erythrocytes, endorsing biochemically the previous serological observations.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Fumiyo Sako: "Characterization of neutral glycosphingolipids from porcine erythrocyte membranes" Int.J.Biochem.19(10). 923-929 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 酒向史代: "新しい構造のAとO(H)型血液型物質-ブタ赤血球の糖脂質-" 北海道医学雑誌. 63(4). 534-544 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fumiyo Sako: "Human blood group glycosphingolipids of porcine erythrocytes" Arch.Biochem.Biophys.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Goro Hanagata: "Characterization of acidic glycolipids in porcine plasma" Glycoconjugate J.(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Goro Hanagata: "Human blood group A and H glycolipids in porcine plasma:evidence for acquisition of the erythrocyte antigens from plasma" FEBS LETTERS(in press).

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fumiyo Sako et al.: "Characterization of neutral glycosphingolipids from porcine erythrocyte membranes." Int. J.Biochem., 19(10), 923-929, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fumiyo Sako: "A novel blood group A- and O(H)-antigens-glycosphingolipids from porcine erythrocytes-(in Japanese)." Hokkaido Igaku Zasshi, 63(4), 534-544, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fumiyo Sako et al.: "Human blood group glycosphingolipids of porcine erythrocytes." Arch. Biochem. Biophys.,.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Goro Hanagata et al.: "Characterization of acidic glycolipids in porcine plasma." Glycoconjugate J.,.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Goro Hanagata et al.: "Human blood group A and H glycolipids in porcine plasma: evidence for acquisition of the erythrocyte antigens from plasma." FEBS Letters,.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Fumiyo Sako: "Characterization of neutral glycosphingolipids from porcine erythrocyte membranes" Int.J.Biochem.19(10). 923-929 (1987)

    • Related Report
      1989 Annual Research Report
  • [Publications] 酒向史代: "新しい構造のAとO(H)型血液型物質-ブタ赤血球の糖脂質-" 北海道医学雑誌. 63(4). 534-544 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fumiyo Sako: "Human blood group glycosphingolipids of porcine erythrocytes" Arch.Biochem.Biophys.

    • Related Report
      1989 Annual Research Report
  • [Publications] Goro Hanagata: "Characterization of acidic glycolipids in porcine plasma" Glycoconjugate J.

    • Related Report
      1989 Annual Research Report
  • [Publications] Goro Hanagata: "Human blood group AandH glycolipids in porcine plasma:evidence for acquisition of the erythrocyte antigens from plasma" FEBS Letters.

    • Related Report
      1989 Annual Research Report
  • [Publications] Fumiyo,Sako: Int.J.Biochem. 19(10). 923-929 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 酒向史代: 北海道医学雑誌. 63(4). 534-544 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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