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Molecular evolutionary study of RNA viral genes.

Research Project

Project/Area Number 63540510
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 遺伝学
Research InstitutionNational Institute of Genetics

Principal Investigator

GOJOBORI Takashi  National Institute of Genetics, Assoc. Prof., 集団遺伝研究系, 助教授 (50162136)

Co-Investigator(Kenkyū-buntansha) MORIYAMA Etsuko  National Institute of Genetics, Res. Asso., 集団遺伝研究系, 助手 (20210198)
HORAI Satoshi  National Institute of Genetics, Res. Asso., 総合遺伝研究系, 助手 (40126157)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1989: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1988: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsRNA viruses / molecular evolution / nucleotide substitution / retroviruses / HTLV-I / II / AIDS viruses / HBV / ミトコンドリア遺伝子 / ヒトの進化
Research Abstract

The aim of this research project was to clarify the evolutionary features of RNA viruses from the viewpoint of molecular evolution. In particular, we studied the rate of nucleotide substitutions of RNA viruses such as human immunodeficiency viruses (HIV) and oncoviruses. We found that the substitution rates of these typical retroviruses are the order of 10^<-3> per site per year. These rates are 10^6 times greater than those of eukaryotic genes including nuclear and mitochondrial genes. Although human hepatitis B virus (HBV) is not a RNA virus, we also examined the rate of nucleotide substitution of HBV. This is because HBV possesses reverse transcriptase that is a polymerase unique to retroviruses. The substitution rate of HBV is estimated to be the order of 10^<-5> per site per year. In the case of human T cell leukemia viruses types I and II (HTLV - I / II), we suggested that the substitution rate is much higher than those of eukaryotic genes but lower than those of retroviruses.
Using the numbers of nucleotide substitutions, we constructed the phylogenetic trees for the above-mentioned viruses. As the result, we concluded that the viruses examined in this research show "host-independent evolution."

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (50 results)

All Other

All Publications (50 results)

  • [Publications] Gojobori,T.: "Molecular evolutionary analysis of AIDS viruses." IV International Conference on Aids.Book 1. 142 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yokoyama,S: "Molecular evolution of the human immunodeficiency and related viruses." Mol.Biol.Evol.5(3). 237-251 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hayasaka,K.: "Phylogenetic relationships among Japanese,rhesus,Formosan,and crab-eating monkeys inferred from restriction enzyme analysis of mitochondrial DNAs." Mol.Biol.Evol.5(3). 270-281 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aota,S.: "Codon usage tabulated from the Genbank Genetic Sequence Data." Nucl.Acids Res.16. r315-r402 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Harihara,S.: "Mitochondrial DNA polymorphism among five Asian populations." Amer.J.Hum.Genet.43. 134-143 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hayasaka,K.: "Molecular phylogeny and evolution of primate mitochondrial DNA." Mol.Biol.Evol.5(6). 626-644 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Moriyama E.N.: "Evolution of rested genes with special reference to caticle proteins in Drosophila melanogaster." J.Mol.Evol.28. 391-397 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu,N.: "Patterns of nucleotide substitutions and implications for the immunological diversity of human immunodeficiency virus." FEBS Letters. 250. 591-595 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Orito,E.: "Host-independent evolution and a genetic classification of the hepadnavirus family based on nucleotide sequence." Proc.Natl.Acad.Sci.USA.89. 7059-7062 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tsujimoto,H.: "Sequence of a novel simian immunodeficiency virus from a wild-caught Africa mandrill." Nature. 341. 539-541 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gojobori,T.: "Evolutionary origin of human and simian immunodeficiency viruses" Proc.Natl.Acad.Sci.USA.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ina,Y.: "Moleular evolution of human T-cell leukemia virus" J.Mol.Evol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamamoto,T.: "Discontinuous evolution of bacterial pathogens:Evidence for species-species transfer in evolution of pathogenio determinants of Escherichia coli and Vibrio cholerae 01.In:Advances in research on cholera and k〓ated diarrheas,Vol.6.(Eds.N.Ohtomo & R.B.Sack" KTK Scientific Publishers, 195-212 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gojobori,T.: "Statistical method for estimating sequence divergence In:Methods in Encymology,(Ed.R.F.Doolittle)" Academic Press,Inc.,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gojobori,T.: "Molecular phylogeny of AIDS viruses and its application to Vaccine development.In:Population Biology of Genes and Molecules(Eds.,J.F.Crow and N.Takahata)" Baifu-Kan, (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Moriyama,E.N.: "Moleular evolution of human and simian immunodeficiency viruses" Springer-Verlag Berlin,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gojobori, T., E. N. Moriyama, and S. Yokoyama: "Molecular evolutionary analysis of AIDS viruses." IV International Conference on Aids. Book1. p142, Stockholm. (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yokoyama, S., L. Chung, and T. Gojobori: "Molecular evolution of the human immunodeficiency and related viruses." Mol. Biol. Evol. 5(3): 237-251. (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hayasaka, K., S. Horai, T. Gojobori, T. Shotake, K. Nozawa, and E. Matsunaga: "Phylogenetic relationships among Japanese, rhesus, Formosan, and crab-eating monkeys inferred from restriction enzyme analysis of mitochondrial DNAs." Mol. Biol. Evol. 5(3):270-281. (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Aota, S., Gojobori, T., Ishibashi, F., Maruyama, T., and Ikemura, T.: "Codon usage tabulated from the Genbank Genetic Sequence Data." Nucl. Acids Res. 16:r315-r402. (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Harihara, S., Saitou, N., Hirai, M., Gojobori, T., Park, K. S., Misawa, S., Ellepola, S. B., Ishida, T., and Omoto, K.: "Mitochondrial DNA polymorphism among five Asian populations." Amer. J. Hum. Genet. 43: 134-143. (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hayasaka, K., Gojobori, T., and Horai, S.: "Molecular phylogeny and evolution of primate mitochondrial DNA." Mol. Biol. Evol. 5(6):626-644. (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Moriyama E. N., and T. Gojobori: "Evolution of nested genes with special reference to cuticle proteins in Drosophila melanogaster." J. Mol. Evol. 28:391-397. (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu, N., Okamoto, T., Moriyama, E. N., Takeuchi, Y., Gojobori, T., and Hoshino, H.: "Patterns of nucleotide substitutions and implications for the immunological diversity of human imunodeficiency virus." FEBS letters 250:591-595. (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Orito, E., M. Mizokami, Y. Ina, E. N. Moriyama, N. Kameshima, M. Yamamoto, and T. Gojobori: "Host-independent evolution and a genetic classification of the hepadnavirus family based on nucleotide sequence." Proc. Natl. Acad. Sci. USA. 86:7059-7062. (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Tsujimoto, H., A. Hasegawa, N. Maki, M. Fukasawa, T. Miura, S. Speidel, R. W. Cooper, E. N. Moriyama, T. Gojobori, and M. Hayami: "Sequence of a novel simian immunodeficiency virus from a wild-caught Africa mandrill." Nature 341:539-541. (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gojobori, T., E. N. Moriyama, Y. Ina, K. Ikeo, T. Miura, H. Tsujimoto, M. Hayami, and S. Yokoyama: "Evolutionary origin of human and simian immunodeficiency viruses." Proc. Natl. Acad. Sci. USA. (1990).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ina, Y., and T. Gojobori: "Molecular evolution of human T-cell leukemia virus." J. Mol. Evol. (1990).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Yamamoto, T., T. Gojobori, E. N. Moriyama, T. Yokota, and S. Kuwahara: Discontinuous evolution of bacterial pathogens: Evidence for species-species transfer in evolution of pathogenic determinants of Escherichia coli and Vibrio cholerae 01. In: Advances in research on cholera and related diarrheas, Vol.6. (Eds. N. Ohtomo and R. B. Sack).KTK Scientific Publishers, Tokyo., 195-212 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gojobori, T., and E. N. Moriyama: Molecular phylogeny of AIDS viruses and its application to vaccine development. In: Population Biology of Genes and Molecules (Eds., J. F. Crow and N. Takahata). Baifu-kan, (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Gojobori, T., E. N. Moriyama, and M. Kimura: Statistical method for estimating sequence divergence. In: Methods in Enzymology, (Ed. R. F. Doolittle).Academic Press, Inc. Orlando, Florida.,

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Moriyama, E. N., and Gojobori, T.: Molecular evolution of human and simian immunodeficiency viruses.Springer-Verlag, Berlin., (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shimizu,N.: "Patterns of nucleatide substitutions and implication for the immunological diversity of human imunodeficiency virus" FEBS letters. 250. 591-595 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Orits,E.: "Hostーindependent evolution and a genetic classification of the hepadnavirus family based on nuclestide sequence." Proc.Natl.Acad.Sci,U.S.A. 89. 7059-7062 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tsujimoto,H.: "Sequence of a novel simian immunodeficiency virus from a wildーcaught Africa mandrill." Nature. 341. 539-541 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Gojobori,T.: "Evolutionary origin of juman and simian immunodeficiency viruses." Proc.Natl.Acad.Sci.U.S.A.

    • Related Report
      1989 Annual Research Report
  • [Publications] Ina,Y.: "Molecular evolution of human Tーcell leukemia virus." J.Mol.Evol.

    • Related Report
      1989 Annual Research Report
  • [Publications] Gojobori,T.: "Population Biology of Genes and Molecules(Eds,J.F.Crow and N.Takahata)" BaifuーKan Japan, 323-340 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Gojobori,T.: "Methods in Enzymology(Ed.R.F.Doolittle)" Academic Press,Inc.Orlands,Florida,

    • Related Report
      1989 Annual Research Report
  • [Publications] Gojobori,T.,;Moriyama,E.N.,;Yokoyama,S.: IV International Conference on Aids.Book 1. 142 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Yokoyama,S.,;Chung,L.,;Gojobori,T.: Mol.Biol.Evol.5(3). 237-251 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hayakawa,K.,;Horai,S.,;Gojobori,T.,et al.: Mol.Biol.Evol.5(3). 270-281 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Aota,S.,;Gojobori,T.,;Ikemura,T.,et al.: Nuel.Acids.Res.16. r315-r402 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Harihara,S.,;Gojobori,T.,;Omoto,K.,et al: Amer.J.Hum.Genet.43. 134-143 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hayasaka,K.,;Gojobori,T.,;Horai,S.: Mol.Biol.Evol.5(3). 626-644 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Shimizu,N.,;Gojobori,T.,et al.: FEBS Lett.

    • Related Report
      1988 Annual Research Report
  • [Publications] Moriyama,E.N.,;Gojobori,T.: J.Mol.Evol.

    • Related Report
      1988 Annual Research Report
  • [Publications] Yamato,T.,;Gojobori,T.,et al.: "Discontinuous evolution of bacterial pathogens:Evidence for species-species transfer in evolution of pathogenic determinants of Escherichia coli and Vibrio cholerae 01.In:Advances" KTK Scientific Publishers, 195-212 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Gojobori,T.,;Moriyama,E.N.,;Kimura,M.: "Statistical method for estimating sequence divergence. In:Methods in Enzymology." Academic Press,Inc.,

    • Related Report
      1988 Annual Research Report
  • [Publications] Gojobori,T.,;Moriyama,E.N.: "Molecular phylogeny of AIDS viruses and its application to vaccine development. In:Population Biology of Genes and Molecules" Baifu-kan/Cambridge Univ.Press.,

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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