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Studies on Histogenesis of Vascular Wall

Research Project

Project/Area Number 63570014
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionSaitama Medical School

Principal Investigator

HIRAKOW Reiji  Saitama Medical School, Department of Anatomy, Professor, 医学部, 教授 (60049773)

Co-Investigator(Kenkyū-buntansha) HIRUMA Tamiko  Saitama Medical School, Department of Anatomy, Assistant, 医学部, 助手 (70118644)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1988: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsVascular wall / Histogenesis / Chick embryo / Smooth muscle / Elastin / Arteries / Veins / Electron microscopy / 内皮 / 中膜
Research Abstract

To date, there are very few ultrastructural investigations on histogenesis of the vascular wall. Thus, to fill the gap of knowledge, we attempted to carry out an electron microscopic study of blood vessels in developing chick.
1. For sake of precise understanding of change in the circulatory tract, three dimensional architecture of blood vascular system in chick embryos was elucidated by scanning electron microscopy of corrosion casts of vessels at representative stages.
2. Informations on the standard state of vascular wall structure were obtained with regard to four different regions of aorta, brachial artery (a.) and vein (v.), and anterior mesenteric a. and v. in chickens 1 day after hatching. The results demonstrated remarkable regional differences never revealed previously.
3. In developing dorsal aorta, smooth muscle cells (SMC) were first recognized beneath endothelium at stage 18 (3 days incubation). Basal lamina-like dense material was found at st 23 (4 d) and elastin was identified at st 34 (8 d).
4. Brachial a. was seen to settle its final course at st 34 (8 d) . SMC was found at st 28 (6 d) and almost simultaneously basal lamina was formed, while elastin did not appear until st 38 (12 d). Secondary collateral brachial v. became apparent at st 36 (10 d) as endothelial tube in the adventitia of the artery.
Of the results mentioned above, 1, 2, and 3 were obtained during the first and second term, and 4 was mainly in the second term. Histogenesis of the intesinal vessels such as coelomic a., v. or anterior mesenteric a., v. and inferior v. cava remain to be clarified. At the present moment, monoclonal antibodies to be used as markers for cardiovascular cells are being produced.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] Hiruma,T.: "Epicardial formation in embryonic chick:a computer-aided reconstruction,scanning,and transmission electron microscopic studues" American Journal of Anatomy. 184. 129-138 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 平光れい司: "血管の発生と解剖" 日本形成外科学会会誌. 9. 7-15 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 平光れい司: "血管壁の発生と分化(シンポジウム)" 解剖学雑誌(抄). 64. 357 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 比留民子: "ニワトリ胚における血管の発生ー大動脈" 解剖学雑誌(抄). 64. 443 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirakow,R.(分担): "Trend in Vertebrate Morphology.H.Splechtna and H.Hilger eds." Fisher,Stuttgart, 647 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirakow,R.(分担): "Etiology and Morphogenesis of Congenital Heart Disease.A.Takao,ed." Futura,New York,

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiruma, T. and Hirakow, R.: "Epicardial formation in embryonic chick heart: computer-aided reconstruction, scanning and transmission electron microscopic studies." American J. Anatomy, 184: 129-138, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirakow, R.: "Anatomy and development of the blood vessels. (in Japanese)" J. Japan Society of Plastic and Reconstructive Surgery, Suppl.to Vol. 9:7-15, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirakow, R.: "Origin and differentiation of the chordate "heart"." Trend in Vertebrate Morphology. H. Splechtna and H.Hilgers. eds. Fischer, Stuttgart, 1989. p.261-263.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirakow, R. and Sugi, Y.: "Intercellular junction and cytoskeleton in the developing chick myocardium." Etiology and Morphogenesis of Congenital Heart Disease. A. Takao, ed. Futura, New York.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirakow, R.: "Development of the Circulatory System. (in Japanese)" Heart Disease. S. Hosoda and T. Sugimoto, eds. Nankodo, Tokyo.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiruma,T.: "Epicardial formation in embryonic chick:a computer-aided reconstruction,scanning,and transmission electron microscopic studues" American Journal of Anatomy. 184. 129-138 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 平光れい司: "血管の発生と解剖" 日本形成外科学会会誌. 9. 7-15 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 平光れい司: "血管壁の発生と分化(シンポジウム)" 解剖学雑誌(抄). 64. 357 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 比留間民子: "ニワトリ胚における血管の発生-大動脈" 解剖学雑誌(抄). 64. 443 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hirakow,R.(分担): "Trend in Vertebrate Morphology.H.Splechtna and H.Hilger eds." Fisher,Stuttgart, 647 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Hirakow,R.(分担): "Etiology and Morphogenesis of Congenital Heart Disease.A.Takao,ed." Futura,New York,

    • Related Report
      1989 Annual Research Report
  • [Publications] 平光〓司: 解剖学雑誌(94回日本解剖学会総会シンポジウム). 64. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 平光〓司: 日本形成外科学会会誌(32回日本形成外科学会総会)教育講演. 9. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 比留間民子: 解剖学雑誌(94回日本解剖学会総会、一般演題). 64. (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 平光〓司: "循環系の発生:心臓病学細田・杉本 編" 南江堂, (1989)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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