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Neuropathological Study of HTLV-I Related Diseases- Adult T-cell Leukemia (ATL) and HTLV-I Associated Myelopathy (HAM)

Research Project

Project/Area Number 63570146
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionKagoshima University

Principal Investigator

SATO Eiichi  Kagoshima University Faculty of Medicine, Professor, 医学部, 教授 (60004579)

Co-Investigator(Kenkyū-buntansha) GOTO Masamichi  National leprosarium Hoshizuka-Keiaien, Division of research and examination, 研究検査科, 科長
HASUI Kazuhisa  Kagoshima University Faculty of Medicine, Lecturer, 医学部, 講師 (70198703)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
KeywordsHTLV-I / HTLV-I associated / Retrovirus / Adult T-cell leukemia (ATL) / myelopathy / Neuropathology / Immunohistochemistry / HTLVーI遺伝子 / Polymerase chain reaction(PCR) / 成人T細胞白血病 / HTLVーIによる肺病変(HAB) / HTLV-I associated myelopathy(HAM) / らい(ハンセン病) / 悪性リンパ腫 / リンパ腫(ATLL) / 中枢神経
Research Abstract

Following studies were performed in order to elucidate the neurological disorders observed in ATL and pathogenesis of HAM. (1) Neurological signs are frequently observed in ATL. Systemic neuropathological study of 41 ATL patient autopsied revealed direct infiltration of leukemic cells in the brain and spinal cord, which were closely related to drowsiness and dementia. Some cases showed giant cells or AIDS-like vacuolar myelopathy, but inflammatory lesions compatible with HAM was not detected in the spinal cord of ATL cases. (2) Based on the hypothesis that migration of HTLV-I infected activated T-cell into the spinal cord through blood-brain barrier is important for the pathogenesis of HAM, population of UCHL-I positive T-cells in the spinal cords of HTLV-I carrier (n=4), non-carrier (n=7), non-endemic area cases (n=17) was semiquantitatively examined. However, there was no significant difference among them. On the contrary, a conventional neuropathology negative clinical HAM case showed more than 3 times increase of T-cells. (3) Distribution of HTLV-I gene in various organs of a HAM case was studied by Polymerase Chain Reaction (PCR) using Tax coding SK45. The spinal cord, sciatic nerve, psoas muscle, lung and liver were Tax positive, while cerebrum, cerebellum, midbrain, pons and kidney were negative. HTLV-I seems to be related to multi-organ inflammatory disorders.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 後藤 正道: "成人T細胞白血病・リンパ腫(ATLL)剖検例の中枢神経病変" 日本病理学会会誌. 77. 238 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 後藤 正道: "成人T細胞白血病・リンパ腫(ATLL)剖検例の脊髄病変ーHAMとの比較" 神経病理学. 9. 134-135 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sato E,et al: "Pathoepidemiological features of adult Tーcell lymphoma/leukemia in ad endemic area: Kagoshima,Japan" Cancer Detection and Prevention. 14. 423-429 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sueyoshi K: "Detection of proviral DNA in an autopsy of HTLVーI associated myelopathy (HAM)ーA polymerase chain reaction (PCR) study"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Goto M: "An autopsy case of HTLVーI associated myelopathy ^*HAM)with multiorgan inflammatory lesions"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Goto M: "Central nervous system lesions in adult T-cell leukemia." Nippon Byori Gakkai Kaishi. 77. 238-238 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Goto M: "Spinal cord lesions in adult T-cell leukemia-comparison with HAM." Neuropathology. 9. 134-135 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sato E: "Pathoepidemiological features of adult T-cell lymphoma/leukemia in and endemic area : Kagoshima Japan." Cancer Detection and Prevention. 14. 423-429 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sueyoshi K: "Detection of proviral DNA in an autopsy of HTLV-I associated myelopathy (HAM) -A polymerase chain reaction (PCR) study"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Goto M: "An autopsy case of HTLV-I associated myelopathy (HAM) with multi-organ inflammatory lesions"

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sueyoshi K,Goto M,Hasui K,Sato E,Shibata D,Tokunaga M: "Detection of proviral DNA in an autopsy of HTLVーI associated myelopathy (HAM)ーA polymerase chain reaction (PCR) study" Acta Pathol Jpn.

    • Related Report
      1990 Annual Research Report
  • [Publications] Goto M,Sato E,Johnochi M.Izumo S.: "An autopsy case of HTLVーI associated myelopathy (HAM) with multiorgan inflammatory lesions" Acta Pathol Jpn.

    • Related Report
      1990 Annual Research Report
  • [Publications] 蓮井和久 他: "T細胞性悪性リンパ腫の電顕細胞形態計測法による検討" 日本網内系学会会誌. 29. 367-381 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sato E,et al: "Pathoepidemiological features of adult T-cell lymphoma/leukemia in an endemic area: Kagoshima,Japan." Cancer Detection and Prevention. 14. (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 後藤正道、清水誠一郎、蓮井知久、徳永正義、佐藤栄一: 日本病理学会会誌. 77(補). 238-238 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 後藤正道、徳永正義、宇宿功市郎、佐藤栄一: 第29回日本神経病理学会会誌. 66-66 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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