| Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 1988: ¥900,000 (Direct Cost: ¥900,000)
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| Research Abstract |
1) Examination of synovial sarcoma by various methods: Electron microscopic observations revealed epithelioid cells with a distinct desmosome, basement membrane and glandular cavity, and fibroblastic cells. Immunohistochemical examination revealed that epithelial cells were positive for keratin and EMA, and basement membrane protein, laminin, and type IV collauen were also demonstrated around the epithelioid cells. In some cages S-100 protein, and NSE- and desmin-positive cells were occasionally observed. Epithelioid cells that were positive for PNA and UEA were revealed by lectin histochemistry. These findings suggest that it is valid to regard the sarcoma as carcinosarcoma composed of adenocarcinoma and a sarcomatous part.
2) Examination of non-neoplastic synovium: None of the morphologically epithelioid findings, presence of markers, as observed above^<1)>, was observed in any of various non-neoplastic synovial tissues. No specific finding that might provide a basis of carcinosarcoma
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was observed.
3) Examination of experimentally induced sarcoma: Initial changes in synovial livina cells due to injection of DMBA into the rat knee joint included atypical hyperplasia and enlargement, but no epithelioid differentiation was observed. It was valid to consider that the histological findings obtained on the tumor indicated undifferentiated sarcoma. There were no markers indicating various degrees of differentiations. This tendency was the point of agreement among;.the various examinations.
4) Comprehensive discussion: Synovial sarcoma should be defined as carcinosarcoma with findinas probably showing various differences. The synovial tissue did not show a tendency toward epithelioid differentiation or various degrees of differentiations, and this tendency was also observed in the experimentally induced sarcoma derived from the synovium. There is no foundation for the concept that synovial sarcoma originates in the synovium, and it seems valid to consider that synovial sarcoma originates in multipotential immature mesenchymal cells. Less
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