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Synthesis and secretion of calcitonin and calcitonin gene-related peptide.

Research Project

Project/Area Number 63570150
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionTokai Univ, School of Medicine

Principal Investigator

KAKUDO K.  Tokai Univ. Dept of Pathol. Assist. Prof., 医学部・病理学, 講師 (00112037)

Co-Investigator(Kenkyū-buntansha) OSAMURA Y.  Tokai Univ. Dept of Pathol. Prof., 医学部・病理学, 教授 (10100992)
WATANABE K.  Tokai Univ. Dept of Pathol. Prof., 医学部・病理学, 教授 (00055865)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
KeywordsThyroid Gland / C cell / Calcitonin / Secretion / Cell cycle / Calcium metabolism / GCRP / カルシトニン遺伝子関連ペプチド / 細胞内プロセシング / 遺伝子プロセシング
Research Abstract

Calcitonin(CT) and calcitonin gene-related peptide(CGRP) are synthesized in and secreted from the C cells of the thyroid. To study regulation mechanism of these peptides, the following studies were carried out and clarified. These 2 peptides are localized in the neurosecretory granules of the human C cells of the thyroid at electron microscopic level. When calcium channel blocker nifedipine was applied on cultured C cells(TT cells), CT secretion in the culture media was reduced and numbers of secretory granules in the TT cells were increased. When synthetic salmon calcitonin (TZ-CT) was injected in rats, tissue CT contents reduced in thyroid markedly. In addition to it, CT-m-RNA in the thyroid dropped at 50-80%. Thus TZ-CT administration suppresses CT-m-RNA translation and CT synthesis. Long term TZ-CT administration in the rats suppressed C cell population in the rats thyroid. This negative feedback mechanism may suggests that C cells may have CT receptors and were regulated CT synthesis and secretion by serum CT levels directly rather than by serum calcium level indirectly.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] Kakudo,K.,Itoh,Y.,Osamura,R.Y.,et al.: "Electron-immunocytochemical localization of calctionin and calcitonin-gene-related peptide in human C cells of the thyroid." Acta Anat.135. 17-21 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kakudo,K.,Itoh,J.,Takekoshi,S.,et al.: "Effects of synthetic salmon calcitonin on C cells of the thyroid." Acta Pathol.Jpn.39. 545-550 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Nakamura,A.,Kakudo,K.,Watanabe,K.,et al.: "Morphological changes of human thyroid medullary carcinoma cell line treated with calcium channel antagonist Nifedipine." Kitasato Arch Exp Med. 61. 195-200 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Lertpresertsuke,N.,Kakudo,K.,et al.: "C cell carcinoma of the thyroid:Follicular variant." Acta Pathol Jpn.39. 393-399 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Metok,R.,Kakudo,K.,Tsuji,Y.,et al.: "Deletion of histo-blood group A and B antigens and expression of incompatible A antigen in ovarian cancer." J Natl Cancer Inst. 81. 1151-1157 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takami,H., Shikata,J.,Kakudo,K.,et al.: "Calcitonin gene-related peptide in patients with endocrine tumors." J Surg Oncol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kakudo,K.: "Progress in Surgical Pathology" KAMEYA,T.and FENOGLIO-PREISER,CM W.W.,Norton and Company, 13 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 覚道健一: "免疫組織化学" 渡辺慶一,文光堂, 358 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kakudo, K., Itoh, Y., Osamura, RY., et al.: "Electron-immunocytochemical localization of calcitonin and calcitonin-gene-related peptide in human C cells of the thyroid." Acta Anat. 135:17-21, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kakudo, K., Itoh, J., Takekoshi, S., et al.: "Effects of synthetic salmon calcitonin on C cells of the thyroid." Acta Patho. Jpn 39:545-550, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Nakamura, A., Kakudo, K., Watanabe, K., et al.: "Morphological changes of human thyroid medullary carcinoma cell line treated with calcium channel antagonist Nifedipine." Kitasato Arch Exp Med 61:195-200, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Lertpresertsuke, N., Kakudo, K., et al.: "C cell carcinoma of the thyroid: Follicular variant." Acta Pathol Jpn 39:393-399, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Metok, R., Kakudo, K., Tsuji, Y., et al.: "Deletion of histo-blood group A and B antigens and expression of incompatible A antigen in ovarian cancer." J Natl Cancer Inst 81:1151-1157, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Takami, H., Shikata, J., Kakudo, K., et al.: "Calcitonin gene-related peptide in patients with endocrine tumors." J Surg Oncol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kakudo,K.,Itoh,Y.Osamura,R.Y.,et al.: "Electron-immunocytochemical localization of calcitonin and calcitonin-gene-related peptide in human C cells of the thyroid." Acta Anat.135. 17-21 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kakudo,K.,Itoh,J.Takekoshi,S.,et al.: "Effects of synthetic salmon calcitonin on C cells of the thyroid." Acta Pathol.Jpn.39. 545-550 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nakamura,A.,Kakudo,K.,Watanabe,K.,et al.: "Morphological changes of human thyroid medullary carcinoma cell line treated with calcium channel antagonist Nifedipine." Kitasato Arch Exp Med. 61. 195-200 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Lertpresertsuke,N.,Kakudo,K.,et al.: "C cell carcinoma of the thyroid: Follicular variant." Acta Pathol Jpn. 39. 393-399 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Metok,R.,Kakudo,K.,Tsuji,Y.et al.: "Deletion of histo-blood group A and B antigens and expression of incompatible A antigen in ovarian cancer." J Natl Cancer Inst. 81. 1151-1157 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takami,H.,Shikata,J.,Kakudo,K.,et al.: "Calcitonin gene-related peptide in patients with endocrine tumors." J Surg Oncol.

    • Related Report
      1989 Annual Research Report
  • [Publications] Kakudo,K.: "Progress in Surgical Pathology" KAMEYA,T.and FENOGLIO-PREISER,CM W.W.,Norton and Company, 13 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 覚道健一: "免疫組織化学" 渡辺慶一,文光堂, 358 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Nakamura,A.: Virch Arch Pathol Anat. 53. 332-335 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 覚道健一: 病理と臨床. 6. 191-200 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kakudo,K.: Brain Res. 440. 153-158 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 覚道健一: 病理と臨床. 6. 778-784 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 覚道健一: 病理と臨床. 6. 790-797 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kakudo,K.: Acta Anat.

    • Related Report
      1988 Annual Research Report

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Published: 1989-04-01   Modified: 2016-04-21  

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