| Project/Area Number |
63570154
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University. |
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Principal Investigator |
MATSUO Takashi TOKYO MEDICAL AND DENTAL UNIV, MEDICAL RESEARCH INSTITUTE, ASSISTANT PROFESSOR., 難治疾患研究所, 助教授 (00165771)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Basal ganglia / Vascular architecture / Carbon monoxide poisoning / Intra cerebral hemorrhage / Fractal / 大脳 / 基底核 / 血管抵抗 |
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| Research Abstract |
1. A series of measurements of pressure drop occurring at arterial branchine, were conducted using model branches with various geometries, and the effect of branching on distal blood supply was studied. It was revealed that in blood circulation, the pressure drop due to branching is important where a small artery divide off with a large branching angle from a large trunk.
2. The pallidum in the basal ganglia was found to be fed by small arteries which divide off from a large trunk and run a long course until they enter the brain parenchima. These features suggest that the pressure drop at the entrance of arteries feeding the palliddum is significant and may play an important role in determining the regional blood flow under carbon monoxide poisoning, where peripheral resistance is maximally reduced and systemic hypotension is superimposed.
3. The arteries feeding the putamen were considerably large compared with those of pallidum and they enter the brain parenchima immediately after branching from a trunk. These features of vascular architecture indicate that the arteries in the putamen are exposed to high pressure, and may relate to selective involvement of this part in hypertensive hemorrhage.
4. The pattern of arteries distributed in the brain was found to be a "fractal" characterized by two fractal dimensions (1.78 and 1.29). The randomness of it is quantitatively represented by the fractal dimension.
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