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Senile Changes in the Brain of Elderly Subjects in Forensic Autopsy Cases

Research Project

Project/Area Number 63570272
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionNagasaki University School of Medicine

Principal Investigator

NAKASONO Ichiro  Nagasaki Unv. Dept. of Legal Med. Prof., 医学部, 教師 (30108287)

Co-Investigator(Kenkyū-buntansha) KUBO Shin-ichi  Nagasaki Unv. Dept. of Legal Med. Instructor, 医学部, 助手 (10205122)
OGATA Mamoru  Nagasaki Unv. Dept. of Legal Med. Assistant Prof., 医学部, 講師 (10152373)
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 1988: ¥1,200,000 (Direct Cost: ¥1,200,000)
Keywordsneuropathology / aging / senile plaques / neurofibrillary tangles / amyloid angiopathy / lipofuscin / senile dementia / アミロイド・アンギオパチー / 痴呆
Research Abstract

Forensic autopsied brains from 57 cases were examined to establish histopathological criteria for normal aging and senile dementia.
Senile plaques, neurofibrillary tangles (NFT), amyloid angiopathy and lipofuscin deposits were quantified in the occipital lobe and hippocampus. Histopathological data were analyzed by the image analyzer.
The primitive senile plaque (SPC) and lipofuscin deposits were observed over age of 50. The senile plaque with core (SPC) and NFT were presented in the cases above 70 year of age. There were close correlation between the individual age in non-demented, and the number, size and occupation ratio of SPC in the occipital lobe and hippocampus. In the dementia cases, the occupation ratio of SPC in the hippocampus and the number of SPP in the occipital cortex were significantly increased against the non-demented group.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] 久保真一: "法医剖検脳からの老人性痴呆診断の試み" 日本法医学雑誌. 44(1). (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Shin-ichi Kubo, Mamoru Ogata, Osamu Kitamura, Minoru Iwasaki and Ichiro Nakasono.: "Histological Study on Possibility of Senile Dementia Diagnosis in Forensic Autopsy Cases." Jpn J Legal Med. 44(1). (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 久保真一: "法医剖検脳からの老人性痴呆診断の試み" 日本法医学雑誌. 44(1). (1990)

    • Related Report
      1989 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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