| Project/Area Number |
63570338
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hokkaido University |
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Principal Investigator |
MIYAMOTO Hiroshi Hokkaido University Hospital Lecturer, 医学部付属病院, 講師 (70002342)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1989: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | Lung cancer / ras oncogene / Host factor / Selenium / Vitamin E / Vitamin A / Micronutrients |
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| Research Abstract |
The purpose of this study is to examine the risk of neoplasma in lung cancer patients and high-cancer-risk individuals.
1. The inducibility of sister chromatid exchange(SCEs) by benzo(a)pyrene(BP): The baseline SCE frequency in cultured lymphocytes was significantly high in lung cancer patients, as compared with all healthy persons or low-cancer-risk individuals. Following exposure to BP, the lymphocytes of lung-cancer patients and high-cancer-risk individuals exhibited significantly greater SCE yields than those of persons at low risk. This findings suggest that lymphocytes of high-risk individuals may be more susceptible to BP-induced DNA damage than those of persons at low risk.
2. Expression of ras oncogene product: MobAb rp35 was used for detection of ras p21 in histologic section of resected lung tumors. Materials of tumors from primary sites larger than 30 mm in diameter exhibited intensely positive reactions with rp-35 significantly more frequently than those with primary sites, 30 mm in diameter or smaller. Patients with negatively or equivocally staining tumor had significantly longer survival times than did those with moderately staining tumor or those with intensely staining tumor. These results suggest that ras oncogene may play a significant role in growth or tumorigenesis at the primary site in lung cancer.
3. Familial factors in micronutrients: Among Family members, particularly, families of adenocarcinoma patients, serum selenium and vitamin E levels were significantly lower than those in controls. These data suggest that there are familial factors in serum selenium and vitamin E levels among families of lung cancer patients.
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