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Measurement of Retino-Cortical Conduction Time using Pattern Reversal Stimulation for Detection of Subclinical Visual Dysfunction.

Research Project

Project/Area Number 63570369
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionOkinaka Memorial Institute for Medical Research (1989-1990)
Iwate Medical University (1988)

Principal Investigator

KUROIWA Yoshiyuki  Okinaka Memorial Institute for Medical Research, 研究員 (40135249)

Co-Investigator(Kenkyū-buntansha) ISHIYAMA Yoji  Okinaka Memorial Institute for Medical Research, 研究員 (80151413)
KONNO Toshiaki  Iwate Medical University, 医学部, 講師 (00146044)
千葉 健一  岩手医科大学, 医学部, 講師 (30146071)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1990: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1988: ¥1,100,000 (Direct Cost: ¥1,100,000)
KeywordsVisual Evoked Potentials / Optic Neuritis / Multiple Sclerosis / Aging / Electroretinogram / Pattern Reversal / Demyelination / 大脳誘発電位 / パタ-ンリバ-サル刺激 / 正常値 / パターンリバーサル視覚誘発電位
Research Abstract

1. Transient pattern reversal visual evoked potentials in 167 healthy subjects.
The subjects consisted of 71 males and 96 females. Their mean age was 45.7 +19.1. A three kinds of check size was used ; 15, 30 & 60 minutes. Measuring parameters consisted of VEP latencies (P50, N75, P100, N145) and VEP amplitudes (N75, P100, N145). Pattern VEP to 15 min checks showed significantly prolonged and larger responses, compared with VEP to 30 or 60 min checks. VEP latency and age showed curvilinear correlation. VEP amplitude and head circumference showed a negative linear correlation. Pattern VEP in males showed significantly prolonged and smaller responses, compared with VEP in females.
2. Transient/Steady-state pattern reversal ERG/VEP in 114 healthy subjects
The mean age of the 114 healthy subjects was 45 years. Two kinds of pattern reversal rates were used ; 0.8 Hz (transient) and 5 Hz (steady-state). Check sizes used were 15, 30 & 60 minutes. ERG was recorded using two gold-foil electrodes placed in lower eyelids. Transient ERG consisted of a(p), b(p) and c(p). Transient VEP consisted of P50, N75, P100 and N145. Steady-state ERG showed peaks of N1, P1, N2, P2, N3 & P3. Steady-state VEP showed peaks of NI, PI, NII, PII, NIII & PIII. Transient or steady-state ERG/VEP latencies showed a curvilinear correlation to age. Retino-cortical time and age showed a curvilinear correlation, too. Transient/steady-state ERG amplitudes decreased with increasing age. VEP amplitudes decreased with increasing head circumference.
3. Pattern reversal ERG/VEP in multiple sclerosis, optic neuritis and HTLV-I associated myelopathy.
There were three types of abnormalities ; (1) normal ERG and prolonged VEP, (2) reduced or absent ERG and prolonged VEP, (3) absent responses in both ERG & VEP.
Our present study contributes to (1) understanding of normal physiological knowledge of visual system, and (2) effective and non-invasive detection of subclinical visual system disorders.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Kuroiwa,Y.: "Clinical significance of visual evoked potentials." Progress in Clinical Neurosci.1. 151-165 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Abe,Y.,Kuroiwa,Y.: "Amplitude asymmetry of hemifield pattern reversal VEPs in healthy subjects." Electroencephalogr.Clin.Neurophysiol.77. 81-85 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 黒岩 義之,他: "パタ-ン反転連続刺激法による潜在的視神経障害の検出感度" 臨床脳波. 31. 220-226 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 山名 大吾,黒岩 義之,他: "パタ-ンリバ-サルVEPの異常を伴ったHTLVーI associated myelopathy αー例" 臨床脳波. 32. 768-772 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 黒岩 義之,他: "老化と視覚誘発電位" 老化と疾患. 3. 1685-1694 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 黒岩 義之,他: "アンケ-ト調査による誘発電位計測の現況 2)視覚誘発電位" 脳波と筋電図. 19. 107-108 (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 黒岩 義之,G.G.Celesia: "視覚誘発電位。その正常波形と臨床応用" 西村書店, 191 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kuroiwa, Y.: "Clinical significance of visual evoked potentials." Progress in Clinical Neurosciences. 1. 151-165 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Abe, Y., Kuroiwa, Y.: "Amplitude asymmetry of hemifield pattern reversal VEPs in healthy subjects." Eletroencephalogr. Clin. Neurophysiol.77. 81-85 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kuroiwa, Y.: "Detection sensitivity of subclinical optic nerve lesions by a method of repetitive pattern reversal stimulation." Clinical EEG. 31. 220-226 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamana, D., Kuroiwa, Y., et al: "A case of HTLV-I associated myelopathy, showing abnormal pattern reversal VEP." Clinical EEG. 32. 768-772 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kuroiwa, Y., Chiba, K, et al: "Aging and visual evoked potentials." Aging and Disease. 3. 1685-1694 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kuroiwa, Y., et al: "Visual evoked potentials." EEG & EMG. 19. 107-108 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kuroiwa, Y., Celesia, G. G.: Nishimura Book Company.Visual Evoked Potentials. Its Normal Waveforms and Clinical Application., 191 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Y.Kuroiwa: "Clinical significance of visual evoked potentials." Progress in Clinical Neurosci. 1. 151-165 (1988)

    • Related Report
      1990 Annual Research Report
  • [Publications] Abe,Y.,Kuroiwa,Y.: "Amplitude asymmetry of hemifield patten reversal VEPs in healthy subjects." Electroencephalogr.Clin.Neurophysiol.77. 81-85 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 黒岩 義之,他: "パタ-ン反転連続刺激法による潜在的視神経障害の検出感度。" 臨床脳波. 31. 220-226 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 山名 大吾,黒岩 義之,他: "パタ-ンリバ-サルVEPの異常を伴ったHTLVーI associated myelopathyの一例。" 臨床脳波. 32. 768-772 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 黒岩 義之,他: "老化と視覚誘発電位" 老化と疾患. 3. 1685-1694 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 黒岩 義之,他: "アンケ-ト調査による誘発電位計測の現況。2)視覚誘発電位" 脳波と筋電図. 19. 107-108 (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 黒岩 義之,G.G.Celesia: "視覚誘発電位.その正常波形と臨床応用" 西村書店, 191 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 黒岩義之、他: "Goldーfoil型電極によるパタ-ン網膜電図の記録に関する基礎的検討" 脳波と筋電図. 18. 94 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Abe,Y.Kuroiwa,Y: "Amplitude asymmetry of hemifield pattern veversal VEPs in healthy subjects" Elaectroencephalogr, Clin. Neurophysiol. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] 黒岩義之、Celesia,G.G.: "視覚誘発電位ーその正常波形と臨床応用" 西村書店, 191 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 黒岩義之 視覚誘発電位: "誘発電位(下地恒毅・編)" 西村書店, (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kuroiwa,Y.;Tohgi,H.;Wada,T.;Abe,Y.;Ohi,K.;Hiroi,S.: Electroencephalogr.Clim.Neurophysiol.70. 116p (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 黒岩義之,東儀英夫,和田知子 他: 臨床脳波. 31. 101-107 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 阿部佳子,黒岩義之: 臨床脳波. 31. 21-28 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 黒岩義之: 神経研究の進歩. 32. 67-78 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 黒岩義之: 岩手医誌. 40. 171-184 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 黒岩義之: 脳波と筋電図. 17. 72 (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] Kuroiwa,Y.Clinical siguificance of visual eooked potentials.: "Progress in Clinical Neurosciences" Continuing Medical Education Programme,Newolofical Society of India,Bihar, (1989)

    • Related Report
      1988 Annual Research Report
  • [Publications] 黒岩義之,Celesia,G.G.: "視覚誘発電位.その正常波形と臨床応用" 西村書店, (1984)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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