• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Clinical and Experimental Studies on Angiogenesis of Coronary Collateral Vessels

Research Project

Project/Area Number 63570389
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

FUJITA Masatoshi  Toyama Med. & Pharm. Univ. Hospital Assistant Professor, 附属病院, 講師 (50190046)

Co-Investigator(Kenkyū-buntansha) ASANOI Hidetsugu  Toyama Med. & Pharm. Univ. Hospital Assistant, 附属病院, 助手 (00150128)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1988: ¥900,000 (Direct Cost: ¥900,000)
KeywordsAngina / Thrombolysis / Collateral circulation / Ventricular aneurysm / Heparin / Collateral recruitment / Collateral development / 冠側副血行循環 / Walkーthrough現象 / ヘパリン療法 / 心筋虚血 / 頻回冠動脈閉塞 / TIー201心筋シンチグラフィ / トレッドミル運動負荷試験 / 冠動脈造影 / 急性心筋硬塞 / ST低下 / 自転車エルゴメ-タ / 冠閉塞 / 狭心症 / ヘパリン運動療法 / 左心室瘤 / 冠動脈内血栓溶解療法 / ドレッドミル運動負荷試験
Research Abstract

Clinical significance of Coronary Collateral Circulation
We found that there is a significant difference in the proportion of patients with post-infarction angina between those with pre-infarction angina but unsuccessful thrombolysis (67%) and those who had neither pre-infarction angina nor recanalization (13%). This suggests that the developed collateral circulation accompanying pre-infarction angina renders myocardial tissue viable in the perfusion territory of the infarct-related coronary artery and causes post-infarction angina because of its limited flow reserve. We also demonstrated that in 10 patients with acute myocardial infarction who had a significant collateral circulation to the infarct-related coronary artery and unsuccessful reperfusion, the left ventricular aneurysm was observed in only one patient (10%), while in 12 patients with unsuccessful recanalization in the absence of a significant collateral perfusion, there was a significantly higher incidence (7/12, 58%) of le … More ft ventricular aneurysm formation. These findings indicate that the well-developed collateral circulation can prevent the left ventricular aneurysm formation probably because of a salutary functional effect of viable islands of residual subepicardial cells in the infarct zone on infarct expansion. In patients with stable effort angina, exercise with heparin pretreatment definitely improved the exercise capability associated with an increase in the extent of opacification of collaterals to the jeopardized myocardium. The development of such a therapeutic modality may attenuate the deleterious sequelae due to coronary artery disease.
Effects of Myocardial Ischemia Coronary Collateral Circulation
We reported the importance of myocardial ischemia for the recruitment of a native collateral circulation. The collateral flow after 5 1 min or a 5 min coronary occlusion was significantly qreater than after 30 10 sec coronary occlusions, where the total occlusion time was identical. We compared the effects of repeated 1 min or 2 min coronary occlusions on the development of collateral circulation. The relative contribution of the first and second 1 min of coronary occlusion to the collateral development was mathematically evaluated. The second 1 min of coronary occlusion was 4.43 fold more effective than the first 1 min of occlusion. Because the extent of myocardial ischemia is more severe during the second 1 min of coronary occlusion, it was concluded that severe ischemia is crucial for the collateral development. Our data indicated the importance of myocardial ischemia for both recruitment and development of coronary collateral circulation. Less

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (59 results)

All Other

All Publications (59 results)

  • [Publications] Fujita Masatoshi: "Significance of preーinfarction angina for occurrence of postinfarction angina." European Heart Journal. 9. 159-164 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita Masatoshi: "Improvement of treadmill capacity and collateral circulation as a result of exercise with heparin pretreatment in patients with effort angina." Circulation. 77. 1022-1029 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fuijta Masatoshi: "Coronary collateral development after acute myocardial infarction." Clinical Cardiology. 11. 525-528 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hirai Tadakazu: "Importance of collateral circulation for prevention of left ventricular aneurysm formation in acute myocardial infarction." Circulation. 79. 791-796 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita Masatoshi: "Clinical significance of coronary collateral circulation." CV World Report. 2. 166-168 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita Masatoshi: "Alleviation of myocardial ischemia by the development of coronary collateral circulation." Japanese Circulation Journal. 53. 1164-1169 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ejiri Michiaki: "Effects of heparin treatment on collateral development and regional myocardial function after acute myocardial infarction." American Heart Journal. 119. 248-253 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Tanaka Kenji: "Improvement of ST segment depression by gradual recruitment of collateral circulation." Cardiology. 77. 17-24 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamanishi Kazuto: "Importance of myocardial ischaemia for recruitment of coronary collateral circulation in dogs." Cardiovascular Research. 24. 271-277 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita Masatoshi: "Coronary collateral development by repetitive coronary occlusions." CV World Report. 3. 156-159 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita Masatoshi: "Importance of myocardial ischemia for coronary collateral development in conscious dogs." International Journal of Cardiology. 27. 179-186 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita Masatoshi: "Significance of collateral circulation in reversible left ventricular asynergy by nitroglycerin in patients with relatively recent myocardial infarction." American Heart Journal. 120. 521-528 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ejiri Michiaki: "Development of collateral circulation after acute myocardial infarction:its role in preserving left ventricular function." Journal of Cardiology. 20. 31-37 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Araie Etsuro: "Heparin exercise treatment following percutaneous transluminal coronary angioplasty for a patient with effort angina." Heart and Vessels. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ohno Akira: "Importance of coronary collateral circulation for increased treadmill exercise capacity by nitrates in patients with stable effort angina pectoris." Cardiologh. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamanishi Kazuto: "Regional myocardial hypertrophy induced by repeated brief coronary occlusion in conscious dogs." American Journal of Cardiovascular Pathology. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita Masatoshi: "Collateral circulation as a marker of presence of viable myocardium in patients with recent myocardial infarction." American Heart Journal. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita Masatoshi: "Comparative effect of heparin treatment with and without strenuous exercise on treadmill capacity in patients with stable effort angina." American Heart Journal. (1991)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 藤田 正俊: "最新内科学大系 循環器疾患5 狭心症" 中山書店, (362)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 藤田 正俊: "狭心症(興和医報別冊)" 興和医報, (176)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Sasayama S, Araie E, Ohno A, Yamanishi K, HIRAI T: "Significance of preーinfarction angina for occurrence of post-infarction angina." European Heart Journal. 9. 159-164 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Sasayama S, Asanoi H, Nakajima H, Sakai O, Ohno A: "Improvement of treadmill capacity and collateral circulation as a result of exercise with heparin pretreatment in patients with effort angina." Circulation. 77(5). 1022-1029 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Sasayama S, Ejiri M, Asanoi H, Nakajima H, Miwa K: "Coronary collateral development after acute myocardial infarction." Clinical Cardiology. 11. 525-528 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Hirai T, Fujita M, Nakaima H, Asanoi H, Yamanishi K, Ohno A, Sasayama S: "Importance of collateral circulation for prevention of left ventricular aneurysm formation in acute myocardial infarction." Circulation. 79(4). 791-796 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Sasayama S: "Clinical significance of coronary collateral circulation." CV Would Report. 2. 166-168 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Sasayama S: "Alleviation of myocardial ischemia by the development of coronary collateral circulation." Japanese Circulation Journal. 53(9). 1164-1169 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ejiri M, Fujita M, Miwa K, Hirai T, Yamanishi K, Sakai O, Ishizaka S, Sasayama S: "Effects of heparin treatment on collateral development and regional myocardial function after acute myocardial infarction." American Heart Journal. 119(2). 248-253 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Tanaka K, Fujita M, Hirai T, Ohno A, Miwa K, Asanoi H, Sasayama S: "Improvement of ST segment depression by gradual recruitment of collateral circulation." Cardiology. 77. 17-24 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamanishi K, Fujita M, Ohno A, Sasayama S: "Importance of myocardial ischaemia for recruitment of coronary collateral circulation in dogs." Cardiovascular Research. 24(4). 271-277 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Sasayama S: "Coronary collateral development by repetitive coronary occlusions." CV World Report. 3. 156-159 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Sasayama S, Ohno A, Yamanishi K, Araie E, Franklin D: "Importance of myocardiad ischemia for coronary collateral development in conscious dogs." International Journal of Cardiology. 27. 179-186 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Yamanishi K, Hirai T, Miwa K, Ejiri M, Asanoi H, Sasayama S: "Significance of collateral circulation in reversible left ventricular asynergy by nitrolgycerin in patients with relatively recent myocardial infarction." American Heart Journal. 120(3). 521-528 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ejiri M, Fujita M, Sakai O, Miwa K, Asanoi H, Sasayama S: "Development of collateral circulation after acutemyocardial infarction : its role in preserving left ventricular function." Journal of Cardiology. 20(1). 31-37 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Araie E, Fujita M, Miwa K, Sasayama S: "Heparin exercise treatment following percutaneous transluminal coronary angioplasty for a patient with effort angina." Heart and Vessels. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ohno A, Fujita M, Miwa K, Ejiri M, Asanoi H, Sasayama S: "Importance of coronary collateral circulation for increased treadmill exercise capacity by nitrates in patients with stable effort angina pectoris." Cardiology. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Yamanishi K, Fujita M, Araie E, Ohno A, Sasayama S, Okada E: "Regional myocardial hypertrophy induced by repeated brief coronary occlusion in conscious dogs." American Journal of Cardiovascular Pathology. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Ohno A, Wada O, Miwa K, Nozawa T, Yamanishi K, Sasayama S: "Collateral circulation as a marker of presence of viable myocardium in patients with recent myocardial infarction." American Heart Journal. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Fujita M, Yamanishi K, Hirai T, Ohno A, Miwa K, Sasayama S: "Comparative effect of heparin treatment with and without strenuous exercise on treadmill capacity in patients with stable effort angina." American Heart Journal. (1991)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ejiri Michiaki: "Effects of heparin treatment on collateral development and regional myocardial function after acute myocardial infarction." American Heart Journal. 119. 248-253 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Tanaka Kenji: "Improvement of ST segment depression by gradual recruitment of collateral circulation." Cardiology. 77. 17-24 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Yamanishi Kazuto: "Importance of myocardial ischaemia for recruitment of collateral circulation in dogs." Cardiovascular Research. 24. 271-277 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Fujita Masatoshi: "Importance of myocardial ischemia for coronary collateral development in conscious dogs." International Journal of Cardiology. 27. 179-186 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Fujita Masatoshi: "Significance of collateral circulation in reversible left ventricular asynergy by nitroglycerin in patients with relatively recent myocardial infarction." American Heart Journal. 120. 521-528 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Fujita Masatoshi: "Coronary collateral development by repetitive coronary occlusions." CV World Report. 3. 156-159 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ejiri Michiaki: "Development of collateral circulaiton after acute myocardial infarction:Its role in preserving left ventricular function." Journal of Cardiology. 20. 31-37 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Fujita Masatoshi: "Comparative effect of heparin treatment with and without strenuous exercise on treadmill capacity in patients with stable effort angina." American Heart Journal. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Fujita Masatoshi: "Collateral circulation as a marker of presence of viable myocardium in patients with recent myocardial infarction." American Heart Journal. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] Ohno Akira: "Importance of coronary collateral circulation for increased treadmill exercise capacity by nitrates in patients with stable effort angina pectoris." Cardiology. (1991)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤田 正俊: "最新内科学大系循環器疾患5 狭心症" 中山書店, 362 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] 藤田 正俊: "狭心症(興和.医報別冊)" 興和医報, 176 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Hirai Tadakazu: "Importance of collateral circulation for prevention of left ventricular aneurysm formation in acute myocardial infarction." Circulation. 79. 791-796 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fujita Masatoshi: "Cl inical significance of coronary collateral circulation." CV World Report. 2. 166-168 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ejiri Michiaki: "Effects of heparin treatment on collateral development and regional myocardial function after acute myocardial infarction." American Heart Journal. 119. 148 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Tanaka Kenji: "Improvement op ST segment depression by gradual recruitment of collateral circulation." Cardiology. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fujita Masatoshi: "Importance of myocardial ischemia for coronary collateral development in conscious dogs." International Journal of Cardiology. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Yamanishi Kazuto: "Importance of myocardial ischaemia for recruitment of coronary collateral circulation in dogs." Cardiovascular Research. (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Fujita,Masatoshi: Circulation. 77. 1022-1029 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Fujita,Masatoshi: Clinical Cardioloqy. 11. 525-528 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Hirai,Tadakazu: Circulation. 79. (1989)

    • Related Report
      1988 Annual Research Report

URL: 

Published: 1988-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi