Isozymic Changes in Myosin of the Cardiac Ventricular Myocardium induced by the Sympathetic Nerve.
| Project/Area Number |
63570414
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
KIMATA Shin-ichi Tokyo Women's Medica college, The Heart Institute of Japan Professor, 医学部, 教授 (40101860)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIZUKA Naoko Tokyo Women's Medica College, The Heart Institute of Japan Associate, 医学部, 助手 (30159751)
TAIRA Atsuko Tokyo Women's Medica College, The Heart Institute of Japan Associate, 医学部, 助手
KAWANA Masatoshi Tokyo Women's Medical College, The Heart Institute of Japan Associate, 医学部, 助手 (20152978)
上田 みどり 東京女子医科大学, 循環器内科, 助手 (10184938)
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1988: ¥1,700,000 (Direct Cost: ¥1,700,000)
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| Keywords | Sympathetic nerve / Catecholamine / Myosin isozyme / SR Ca^<++> ATPase / Heart failure / 心不全 / 心肥大 / ミオシン |
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| Research Abstract |
(1) Isozymic changes in myosin of rabbit ventricular myocardium induced by the sympathetic nerve.
Cardiac myosin has two isozymes alpha and beta. alpha-myosin has high ATPase activity and its contraction is rapid but the energy efficiency is poor. On the other hand, beta-myosin has low ATPase activity, and its contraction is slow but the energy efficiency is good. After complete denervation of the sympathetic nerves, alpha myosin disappeared and was replaced by beta myosin in the cardiac ventricle. By beta sympathetic nervous receptor stimulated with isoproterenal, alpha myosin decreased and beta myosin increased.
(2) Isozymic changes in myosin of the ventricular myocardium in patients with congestive heart failure.
There was a good correlation between the ratio of alpha myosin and the dosage of catecholamine administered in the last stage. In the heart of human beings, also, alpha myosin was increased by catecholamine.
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Report
(2 results)
Research Products
(10 results)
