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Isozymic Changes in Myosin of the Cardiac Ventricular Myocardium induced by the Sympathetic Nerve.

Research Project

Project/Area Number 63570414
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Women's Medical College

Principal Investigator

KIMATA Shin-ichi  Tokyo Women's Medica college, The Heart Institute of Japan Professor, 医学部, 教授 (40101860)

Co-Investigator(Kenkyū-buntansha) ISHIZUKA Naoko  Tokyo Women's Medica College, The Heart Institute of Japan Associate, 医学部, 助手 (30159751)
TAIRA Atsuko  Tokyo Women's Medica College, The Heart Institute of Japan Associate, 医学部, 助手
KAWANA Masatoshi  Tokyo Women's Medical College, The Heart Institute of Japan Associate, 医学部, 助手 (20152978)
上田 みどり  東京女子医科大学, 循環器内科, 助手 (10184938)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥2,300,000 (Direct Cost: ¥2,300,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1988: ¥1,700,000 (Direct Cost: ¥1,700,000)
KeywordsSympathetic nerve / Catecholamine / Myosin isozyme / SR Ca^<++> ATPase / Heart failure / 心不全 / 心肥大 / ミオシン
Research Abstract

(1) Isozymic changes in myosin of rabbit ventricular myocardium induced by the sympathetic nerve.
Cardiac myosin has two isozymes alpha and beta. alpha-myosin has high ATPase activity and its contraction is rapid but the energy efficiency is poor. On the other hand, beta-myosin has low ATPase activity, and its contraction is slow but the energy efficiency is good. After complete denervation of the sympathetic nerves, alpha myosin disappeared and was replaced by beta myosin in the cardiac ventricle. By beta sympathetic nervous receptor stimulated with isoproterenal, alpha myosin decreased and beta myosin increased.
(2) Isozymic changes in myosin of the ventricular myocardium in patients with congestive heart failure.
There was a good correlation between the ratio of alpha myosin and the dosage of catecholamine administered in the last stage. In the heart of human beings, also, alpha myosin was increased by catecholamine.

Report

(2 results)
  • 1990 Final Research Report Summary
  • 1989 Annual Research Report

Research Products

(10 results)

All Other

All Publications (10 results)

  • [Publications] 木全 心一,川名 正敏,平 敦子,石塚 尚子,他: "心肥大の悪化と改善" 呼吸と循環. 35. 723-733 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 川名 正敏,木全 心一,他: "肥大心および不全心におけるヒト心筋ミオシンの変化" Theraperitic Research. 7. 45-51 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 石塚 尚子: "正常心および病的心におけるヒト心筋ミオシンアイソザイムの分布" 東女医大誌. 57. 1557-1566 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kimata S, Kawana M, Taira A, Isizuka N et al: "Deterioration and improvement of cardiac hypertropy" Kokyu to junkan. 35. 723-733 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Kawana M, Kimata S et al: "Myosin isozyme distribution in normal and overload human Heart-An immunohistochemucal study using monoclonal antibodies." Theraperitic Research. 7. 45-51 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Isizuka N: "Isozymic changes in myosin of human ventricular myocardium." J. Tokyo Women's Medical College. 57. 1557-1566 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Tsuchimochi H, Kawana M, Kimata S et al: "Atrial natriuretic peptide distribution in fetal and failed adult human hearts." Circulation. 78. 920-927 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Ishizuka N, Kawana M, Taira A, Kimata S et al: "Isozymic changes in myosin of rabbit ventricular myocardium induced by isoproterenol." Jap. Circul. J.53. 905 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Tsuchimochi H, Kawana M, Kimata S et al: "Expression of interleukin 1 in DCM hearts." Jap. Circul. J.53. 522 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Masatoshi Kawana,Shin-ichi Kimata et al: "Effects of Cardiac Sympathetic Nerve activity on Myosin Isozymes of Rabbit Hearts" Circulation. 80. II462 (1989)

    • Related Report
      1989 Annual Research Report

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Published: 1988-03-31   Modified: 2016-04-21  

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