| Project/Area Number |
63570415
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
SUGAWARA Motoaki Tokyo Women's Medical College The Heart Institute of Japan Associate Professor, 日本心臓血圧研究所, 助教授 (60010914)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Kenji Tokyo Women's Medical College The Heart Institute of Japan Lecturer, 日本心臓血圧研究所, 講師 (10075541)
NAKANO Kiyoharu Tokyo Women's Medical College The Heart Institute of Japan Research Associate, 日本心臓血圧研究所, 助手 (10138919)
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| Project Period (FY) |
1988 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 1988: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | Regional work / Contractility / Wall stress / Wall thickness / Regional Work / Wall Stress / Wall Thickness / Myocadial Infarction / Echocardiography |
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| Research Abstract |
We introduced a new method of defining regional work and regional elastic modulus of the myocardium of the ventricular wall using the relationship between mean wall stress(sigma) and the natural logarithm of reciprocal of wall thickness(1n(1/H)). The area surrounded by the loop described by the sogma-1n(1/H) relationship during a cardiac cycle is equal to regional work per unit volume of myocardium per stroke. The slope of the sigma-1n(1/H) relationship corresponds to Young's modulus of an incompressible Hookean material. The end-systolic sigma-1n(1/H) data point moves on a rectilinear line during preand afterloadings. The slope of this line is not affected by alterations in preand afterloads, but changes significantly due to the changes in the contractile state. Therefore, the slope can be regarded as the normalized Emax, i.e., a normalized index of myocardial contractility.
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