Project/Area Number |
63570461
|
Research Category |
Grant-in-Aid for General Scientific Research (C)
|
Allocation Type | Single-year Grants |
Research Field |
Pediatrics
|
Research Institution | Nihon University |
Principal Investigator |
KIKKAWA Yumio Assistant Professor, Department of Pediatrics, Nihon University School of Medicine, 医学部・小児科 (20059463)
|
Co-Investigator(Kenkyū-buntansha) |
INAGE Zenshiro Research Staff, Department of Pediatrics, Nihon University School of Medicine, 医学部小児科, 助手
MIMURA Akiro Research Staff, Department of Pediatrics, Nohon University School of Medicine, 医学部小児科, 助手
稲毛 善四郎 日本大学, 医学部・小児科, 助手
|
Project Period (FY) |
1988 – 1990
|
Project Status |
Completed (Fiscal Year 1990)
|
Budget Amount *help |
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
|
Keywords | Renal glomerular diseases / Sulfatides / Glomerular epithelial cells / IgA nephropathy / Cellular hypersensitivity / Active E-rosette assay / T cells / Interstitium / Fabry病 / Ceramide trihexoside / 遠位尿細管 / Sulfotransferase / ラミニン / トロンボスポンジン / 間質性腎炎 / ブドウ膜炎 / sulfatide / 抗sulfatide抗体 / 尿中β_2-microglobulin / 近位尿細管 / 糸球体係蹄壁上皮 / 含硫糖脂質 / 糖脂質分析 / 薄層クロマトグラフィー / 中性糖脂質 / 酸性糖脂質 / Globoside |
Research Abstract |
Antibodies to the intrinsic tubular structural component sulfatide aros in renal glomerular diseases, although there was no proof of their nephritogenicity. It is known that the distribution of sulfatides in human tissues is relatively restricted. Sulfatides are especially rich in brain, retina, gastrointestinal tract and kidney of mammalian. Region-specific distribution of sulfatides has been demonstrated in human kidney. In the present study, positive staining with sulfatides was observed in the glomerular epithelial cells of FGS and IgA nephropathy. It was suggested that injury to epithelial cells may lead to large changes in mesangial structure. Recently, we have evaluated cellular hypersensitivity to sulfatides in glomerulonephritis using the active E-rosette assay. Our work suggests that positive results occur during an active or progressive phase of the disease. T-cells are Present rarely in glomeruli and commonly in interstitium. The interstitium, as well as the glomerulus, is involved in the disease process. Local lymphokine production may contribute to immune renal injury.
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