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Dementia in aged and papova virus infection

Research Project

Project/Area Number 63570515
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionTokyo Metropolitan Institute of Gerontology

Principal Investigator

MORI Mayumi  Tokyo Metropolitan Institute of Gerontology, 研究員 (50110698)

Co-Investigator(Kenkyū-buntansha) TAGIMA Masako  Teikyo University, Virology, ウィルス検査部, 主任
SHIMADA Hiroyuki  Tokyo Metropolitan Inst. Gerontology, 研究員 (60113487)
KURATA Hirokazu  Tokyo Metropolitan Inst. Gerontology
倉田 寛一  東京都老人医療センター, 医員
Project Period (FY) 1988 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1989: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1988: ¥1,100,000 (Direct Cost: ¥1,100,000)
Keywordsdementia / papova virus / JC virus / 痴呆
Research Abstract

(1) In the aged cases over 60 years old, the average HI antibody titer for JCV was significantly higher than that for BKV.
(2) In the aged persons, the high antibody titer prevalance rate (1024<) for JCV was also higher than that for BKV.
(3) In the results with EIA, the significant increase in the papova anti body titer was observed in the elderly groups older than 70 years.
(4) Seven brains taken at autopsy from the patients aged 68 to 85 years were studied for JC viral DNA and common papova viral capsid protein (vp-1). In situ hybridization to JC viral DNA was performed by affinity cytochemistry using a biotinylated fragment of JC viral DNA. Immunohistochemistry was carried out on brain tissue by the avidin DH-biotinylated horseradish peroxidase technique using polyclonal antibody raised against the papova viral capsid protein. Viral protein and DNA were detected in 4 cases out of 7 cases. JC virus may be present sometimes in brain of aged patient.

Report

(3 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Mayumi Mori,H.,Shimada,M.,H.Kurata: "JC virus detection in brain tissues from elderly patients by in situ hybridization" Annal Neurol.

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田島マサ子,武田史子,森眞由美,嶋田裕之: "高齢者におけるパポバウィルス(JCV,BKV)に対する抗体調査"

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 田島マサ子: "脳組織におけるIn situ hybridization法によるPapova virus(JC)核酸の検索ー免疫組織化学染色法(ABCーGO)との併用" 臨床病理. 37. 78 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大園治美,田島マサ子: "進行性多巣性白質脳症における髄液細胞内JCウィルス核酸と外被蛋白の検出" 医学のあゆみ. 150. 495-496 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Mayumi Mori, Hirokazu Kurata, Masako Tajima, Hiroyuki Shimada: "JC virus detection in brain tissues from elderly patients by in situ hybridization" Contributing to Annal Neurol.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Masako TAJIMA, Fumiko TAKEDA Maumi MORI, Hiroyuki SHIMADA: "Prevalence of the Antibody against Polyoma viruses(JCV and BKV) in Aged persons" Contributing to Infectious Disease.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] M.Mori.M.H.Shimada,H.Kurata: "JC virus dection in brain tissues from elderly patients by in situ hybridization" Annal Neurol.

    • Related Report
      1989 Annual Research Report
  • [Publications] 田島マサ子,武田史子,森眞由美,嶋田裕之: "高齢者におけるパポバウィルス(JCV,BKV)に対する抗体調査"

    • Related Report
      1989 Annual Research Report
  • [Publications] 田島マサ子: "脳組織におけるIn situ hybridization法によるpapova virus(JC)核酸の検索ー免疫組織化学染色法(ABC-GO)との併用" 臨床病理. 37. 78 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大國治美,田島マサ子: "進行性多巣性白質脳症における髄液細胞内J.Cウィルス核酸と外被蛋白の検出" 医学のあゆみ. 150. 495-496 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] M.Mori,;H.Shimada,;M.Tagima.: Ann.Neurol.

    • Related Report
      1988 Annual Research Report
  • [Publications] 倉田寛一、森真由美 他: 臨床血液.

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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