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Clinical Features and Thyroid Histology of T3-Predominant Graves' Disease.

Research Project

Project/Area Number 63570553
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内分泌・代謝学
Research InstitutionOsaka Medical College

Principal Investigator

TAKAMATSU Junta  Osaka Medical College Assistant Professor., 医学部, 講師 (00140137)

Co-Investigator(Kenkyū-buntansha) OHSAWA Nakaaki  Osaka Medical College, Professor., 医学部, 教授 (90010090)
NAKAI Masayo  Osaka Medical College, Professor., 医学部, 教授 (42084832)
KITAOKA Haruko  Osaka Medical College, Assistant, 医学部, 助手 (00214784)
HOSOYA Toichiro  Chiba Univ. Pharmaceutical Sci., Professor., 薬学部, 教授 (10019648)
中井 益代  大阪医科大学, 医学部, 教授 (20084832)
福田 市蔵  大阪医科大学, 医学部, 講師 (00084864)
Project Period (FY) 1988 – 1990
Project Status Completed (Fiscal Year 1990)
Budget Amount *help
¥1,900,000 (Direct Cost: ¥1,900,000)
Fiscal Year 1990: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1989: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1988: ¥700,000 (Direct Cost: ¥700,000)
KeywordsGraves' disease / Triiodothyronine / Thyroid peroxidase / Thyroglobulin / Antithyroid drug / Radioiodine therapy / Thyroid epithelial cell / 5'-deiodinase / T_3優位型バセドウ病 / 甲状腺刺激性抗体 / 甲状腺 / 脱ヨ-ド酵素 / アイソト-ブ治療 / 血中甲状腺刺激性抗体 / カップリング反応 / 甲状腺機能亢進症 / トリヨードサイロニン / 甲状腺ペルオキシダーゼ / 甲状腺腫 / ペルオキシダーゼ血中自己抗体 / マイクロゾーム血中自己抗体
Research Abstract

When patients with T_3 -predominant Graves' disease were compared with usual Graves' disease patients,
1. Serum autoantibodies to thyroid peroxidase and TSH receptor were higher, while autoantibodies to thyroglobulin were not different. Thyroid-stimulating antibodies determined by cultured porcine thyroid cells were greater.
2. The goiter size was greater with more hyperplastic epithelium and more intracolloidal vacuoles.
3. Thyroid ^<123>I uptake was higher at 3h than 24h, suggesting enhanced thyroidal iodine turnover.
4. The degree of exophthalmos of Graves' disease was not different.
5. The activity of thyroid peroxidase was greater, while thyroglobulin content in the thyroid was smaller. Iodine content in thyroglobulin was also smaller. Thyroid 5' -deiodinase was greater, which may be one of the causes of increased serum T_3 relative to T_4.
6. An experiment of coupling reaction using individual microsomal fractions and pooled thyroglobulin showed relatively increased T_3 production than T_4, suggesting a unique characteristic of thyroid peroxidase in this disorder.
7. Clinical follow-up study showed that remission of hyperthyroidism was hardly obtained by antithyroid drug therapy. After subtotal thyroidectomy, the frequency of relapse was greater. While, after radioiodine therapy, the frequency of late-onset hypothyroidism was lower, indicating that radioiodine therapy is beneficial in this type of Graves' disease.

Report

(4 results)
  • 1990 Annual Research Report   Final Research Report Summary
  • 1989 Annual Research Report
  • 1988 Annual Research Report
  • Research Products

    (23 results)

All Other

All Publications (23 results)

  • [Publications] Takamatsu J: "Enhancecl thyroidal iodine metabolism in patients with oviodothyromineーpredominant Graves' disease." Journal of Clinical Endocrinobogy and Metabolism. 66. 147-152 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 高松 順太: "T_3優位型バセドウ病の定義とその成因" 医学のあゆみ. 149. 694-694 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] 高松 順太: "T_3優位型バセドウ病(T_3ーpredominant Graves' disease)の発見とその後の追究:七傑賞受賞講演" ホルモンと臨床(秋季増刊号). 37. 19-30 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takamatsu J: "Eanges in sereum autocntibodies to thyroid peroxidase during antithyroid drug therpy for Graves' disease." Endocrinologia Joponica. 37. 275-283 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takamatsu J(分担執筆): "The Thyroid 1988" Excerpta Medica, 428 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takamatsu J(分担執筆): "Progress in Thyroidology 1989" Korea Medical Publishing Co., 635 (1990)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takamatsu J, HOsoya T, Naito N, Yoshimura H, Kohno Y, Tarutani O, Kuma K, Sakane S, Takeda K and Mozai T: "Enchanced thyroidal iodine metabolism in patients with triiodotyronine-predominant Graves' disease." J Clin Endocrinal Metab. 66 (1). 147-152 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sugawara M, Kita K, Lee ED, Takamatsu J, Hagen GA, Kuma K and Madeiros-Neto GA: "Deficiency of superoxide dismutase in endemic goiter tissue." J Clin Endocrinal Metab. 67(6). 1156-1161 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takeda K, Takamatsu J, Sakane S, Ikegami Y, Majima M, Kitaoka H, Akagi H, Kobayashi A, Matsuzuka F, Kuma K.: "Determination of thyroid gland volume by a newly developed ultrasound technique." Bulletin of the Osaka Medical College. 34(1, 2). 61-67 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takamatsu J. Hosoya T, Kohno Y, Tarutani O, Sugawara M, Sakane S, Takeda K, Kltaoka H and Kuma K: "T_3-predominant Graves' disease : clinical characteristics and pathogenesis of T_3 overproduction" The Thyroid 1988 (eds : Nagataki S, Torizuka K), Excerpta Medica, Amsterdam-New York Oxford. 257-260 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takamatsu J, Hosoya T, Kohno Y, Naito N, Sakane S, Takeda K, Kuma K and Ohsawa N: "Changes in serum autoantibodies to thyroid peroxidase during antihyroid drug therapy for Graves' disease." Endocrinal Japon. 37(2). 275-283 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takamatsu J, Ikegami Y, Sakaen S, Takeda K, Kitaoka H, Kuma K and Ohsawa N.: "Prediction of the outcome of hyperthyroidism due to Graves' disease before antihyroid drug therapy is embarded." Progress in thyroidology 1989 (Proceedings of the 4th. Asia and Oceania Thyroid Association, eds : Lee M, Koh CS, Eastman CJ, Nagataki S). 435-438 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Sakane S, Takamatsu, J, Yoshida S, Takeda K, Ohsawa N, Katayama S, Kuma K, Kohno Y and Hosoya T.: "Clinical features and characteristics of thyroid function in Graves' disease patients with multiple edeomatous hyperplasia" Progress in Thyroidology 1989 (Proceedings of the 4th. Asia and Oceania Thyroid Association, eds : Lee M, Koh CS, Eastman CJ. Nagataki S). Korea Medical Publishing Co, Seoul, Korea. 403-406 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1990 Final Research Report Summary
  • [Publications] Takamatsu J: "changes is serum auto antibodies to thyroid peroxidase during antithyroid drug therapy for Graves disease." Endocrinobogia Japonica. 37. 275-283 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Sakane S: "Clinical features and characteriotics of thyroid function in Graves'disease patients with multiple adehomatous hypesplasia" Progress in Thyroidobogy 1989.(Eds:Lee,Koh) Korea Medical Pubbiching Co.Seoul,Korea. 403-406 (1989)

    • Related Report
      1990 Annual Research Report
  • [Publications] 高松 順太: "診断の進め方と治療方針:Basedow病" 臨床医. 16. 1302-1305 (1990)

    • Related Report
      1990 Annual Research Report
  • [Publications] Takamatsu J: "Enhanced Thyroid iodine wetabolism in patieuts wtih triiodothyronuine-predowinant Graves'disease." Journal of climical Endocrinology&Metabolism. 66. 147-152 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] Sugawara M: "Deticiency of Superoxide dismutase inendemicgoiter tissue" Journal of clinical Endocrinology&Metabolism. 67. 1156-1161 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 高松順太: "T_3優位型バセドウ病の定義とその成因" 医学のあゆみ. 149. 693 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 高松順太: "T_3優位型バセドウ病(T_3-predominant Graves'disease)の発見とその後の追究" ホルモンと臨床(秋季増刊号). 37. 19-30 (1990)

    • Related Report
      1989 Annual Research Report
  • [Publications] Takamatsu J: "The Thyroid 1988" Excerpta Medica 1Amsterdam-New York-Oxford, 3 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 医学のあゆみ.

    • Related Report
      1988 Annual Research Report
  • [Publications] Takamatsu,J.: "The Thyroid 1988" Excerpta Medica., 257-260 (1988)

    • Related Report
      1988 Annual Research Report

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Published: 1988-04-01   Modified: 2016-04-21  

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